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Eutheria Bio

Eutheria Bio is listed as a new startup research supplier in the Scientist.com network, with 2 sites in 1 country.

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Sites 2

Countries 1

Type of company: New startup

Agricultural Sciences Research & Development

Molecular Markers Use of molecular diagnostics to analyze biological markers in the genome and proteome.

Animal Science and Welfare Audits

Vivarium Support Source procurement, housing, husbandry, and care of laboratory animals as well as designing, building and managing vivarium facilities.

Antibodies

Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.

Bioimaging

In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.

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Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Focus Forming Assay Use colorimetric or immunofluorescence-based readouts to quantify virions prior to any plaque formation.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
TUNEL Assay Detect in situ DNA fragmentation.

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Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

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Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.

Chemical and Compound Analysis

Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Total Internal Reflection Fluorescence Microscopy Visualize single molecule fluorescence at a surface to produce high quality images with low background.

Chemistry, Manufacturing and Controls (CMC)

ICH-compliant stability testing Perform ICH-compliant stability testing

Clinical Trials

Patient Recruitment Recruit and retain patients for clinical trials.
Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Discovery Chemistry

Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...

Disease Models

Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Critical Care Models Diagnose and manage life-threatening conditions requiring sophisticated organ support and invasive monitoring.
Cyp2f2 Knockout Mouse Study Cyp2f2-mediated lung metabolism.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.

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Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Kidney Transplant Models Measure therapeutic endpoints in kidney transplant models.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
Osteoporosis Models Measure therapeutic endpoints in animal models of osteoporosis.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.

Effectiveness

In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...

In Vitro ADME

Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Anti-thrombin Assays Use clotting and chromogenic assays to detect and classify anti-thrombin deficiency.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.

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BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Human Cell Assays Request in vitro human cells for assays
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
Serine Protease Assay Detect apoptosis by measuring protease activity.
Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.
Von Willebrand Factor Analysis Detect and classify the Von Willebrand disease sub-type.

In Vitro Pharmacology

High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Hemolysis Assay Evaluate the toxicity of a drug, metabolite or excipient by hemolytic release of hemoglobin in the plasma.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.

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In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.

In Vivo ADME

Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.

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Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
NMRI Mouse Use a single animal species to create one or more disease models for cachexia and hemophilia.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.

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SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Oncology Models

Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
Murine Adenocarcinoma 16 (MAC16) Murine Test for therapeutic efficacy of drug candidates in muscle wasting models.
NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Noble Rat Use a single animal species to create one or more disease models for hematopoiesis.

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Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.
Urinary System Xenografts Xenografts derived from organs of the Urinary system. This includes, but is not limited to, xenografts from the Bladder, Kidney, and Urethra.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Viral Testing Characterize viral products for functional activity and possible contamination.

Protein Sciences

Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Low Density Lipoprotein (LDL) Uptake Assay Investigate low density lipoprotein uptake and regulation at the cellular level.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

REACH Services

OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.

Safety Pharmacology

Conditioned Place Preference or Aversion Study - Mouse Conduct a study to establish the aversion or conditioned place preference and determine the motivational effect of your compound in mice.
Drug Discrimination Study - Other Species Conduct a study to investigate the length of psychoactive effects of your compound in other species and conduct dose range finding for further studies.
Drug Discrimination Study - Rat Conduct a study to investigate the length of psychoactive effects of your compound in rats and conduct dose range finding for further studies.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Self Administration Study - Rat Conduct a study to investigate the potential addictive characteristics of your compound in rats.

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Telemetry Use implantable or external devices to study physiological parameters in model organisms

Scientific Data Services

Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.

Other services

In Vivo Hollow Fiber Assay Evaluate test items concurrently with three different tumor cell lines within the same mouse.
New Request

Website: eutheriabioscience.com

United States Monroe Township, San Diego 2 sites

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