Trans Chromosomics, Inc.

Trans Chromosomics, Inc. is listed as a research supplier in the Scientist.com network, with 2 sites in 1 country.

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Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.

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Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.

Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Multidrug Resistance Identify potential causes of drug-drug interactions.

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Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Custom Model Development Develop a custom disease model.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Phage Display Use in vitro screening method to identify protein binding partners.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.

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