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Syncrosome
Syncrosome is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 3 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Immunodetection Use antibodies to identify a protein or antigen.
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
- In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
- Magnetic Resonance Imaging Use MRI to obtain chemical and physical information about molecules and map the internal structure of an object.
- Medical Imaging Visualize and analyze internal structures in animal models or patients.
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Biomarkers
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Platelet Function Testing Evaluate complete platelet function in vivo or in vitro.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Cell Culture and Characterization
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Show all 78 services
Chemical and Compound Analysis
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Clinical Consulting
- Biometrics Consulting Apply statistics and mathematics to drug discovery, clinical trials, and data analysis.
- Biostatistics Consulting Apply statistical theory and mathematical principals to research
Data Science/Bioinformatics
- Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
Discovery Chemistry
- Ecarin Clotting Time (ECT) Monitor the anti-coagulation effects of new drugs or clinical therapies.
Disease Models
- 6-OHDA-Induced Parkinson’s Disease (PD) The 6-OHDA (6-hydroxydopamine) model is a classic, widely used preclinical animal model for studying Parkinson’s Disease (PD)
- Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
- Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
- Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
- Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Show all 32 in Disease Models
- Cognition Models Measure therapeutic endpoints in animal models of cognition.
- Cough Models Test the therapeutic efficacy of drug candidates in cough models.
- Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
- Emesis Models Measure therapeutic endpoints in animal models of emesis.
- Imiquimod (IMQ)-Induced Psoriasis The Imiquimod (IMQ)-Induced Psoriasis Model is a widely used preclinical mouse model where topical application of IMQ cream stimulates immune cells to trigger psoriasis-like skin inflammation
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
- Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
- Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
- LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
- LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
- MC903-Induced Atopic Dermatitis (AD) The MC903-Induced Atopic Dermatitis (AD) Model is a widely used, rapid, and reproducible preclinical mouse model that closely mimics human eczema
- MC903-Induced Pruritus The MC903-induced pruritus model is a widely used preclinical platform in mice for studying itch mechanisms and screening antipruritic therapies
- Microdialysis Models Measure the effect of drug candidates on neurotransmission in rat or mouse models.
- Microsurgery in Rodents Outsource microsurgeries projects required for testing new therapies on a rodent model.
- Neurological Neurological Pharmacology CROs specialize in in vivo high-throughput model systems to profile pre-clinical candidates for treat...
- Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
- Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
- OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
- Pain Models Test therapeutic efficacy of drug candidate in pain model.
- Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
- Stroke Models Measure therapeutic endpoints in animal models of stroke.
- Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
- Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
In Vitro Assays
- Anti-thrombin Assays Use clotting and chromogenic assays to detect and classify anti-thrombin deficiency.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
Show all 7 in In Vitro Assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
In Vitro Pharmacology
- In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
- Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Custom Model Development Develop a custom disease model.
- Pre-clinical Animal Surgery Conduct surgey in animals used as pre-clinical models.
- Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
- Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Oncology Models
- Animal Hypoxia Models Measure therapeutic endpoints in hypoxic animal models.
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Pharmacology
- In Vivo Pharmacology Study the effects of drug candidates in animal models
Protein Sciences
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
REACH Services
- OECD 402: Acute Dermal Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test chemical by dermal route.
- OECD 410: Repeated Dose Dermal Toxicity: 21/28-day Study This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance.
- OECD 411: Subchronic Dermal Toxicity: 90-day Study This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance.
Safety Pharmacology
- Locomotor Activity Assessment Study - Rat Conduct a study to determine the psychostimulant or sedative activity or your compound in rats.
Service areas:
Where it operates
Sites by country, with the cities in each.
-
France 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Syncrosome is a Preclinical Drug Evaluation Company specialised in human health - we perform pharmacological in vivo studies on physiopathological models. Our professional expertise allows us to complete studies independently or to work in parallel with your in-house research teams after preliminary in vitro screenings. With a 10 years’ experience, we have been conducting in vivo studies for many well known sponsors (top ten pharma’s as well as biotechs) in our own labs. Regularly, we are inspected by the French Direction of Veterinary Services (DSV) and the French Agency of Sanitary Safety...
Show the full description
Syncrosome is a Preclinical Drug Evaluation Company specialised in human health - we perform pharmacological in vivo studies on physiopathological models.
Our professional expertise allows us to complete studies independently or to work in parallel with your in-house research teams after preliminary in vitro screenings.
With a 10 years’ experience, we have been conducting in vivo studies for many well known sponsors (top ten pharma’s as well as biotechs) in our own labs.
Regularly, we are inspected by the French Direction of Veterinary Services (DSV) and the French Agency of Sanitary Safety of Health Products (AFSSAPS). In addition, we are visited an audited by our customers.
Our expertise is focused on three areas :
- Proof of concept in vivo with Central Nervous Sytem, Cardiovascular, Respiratory and Gastroenterological models in routine.
- Early Safety pharmacology, using innovative and appropriate methods of functional exploration.
- Early bioavailibility and CNS-pK on different species with a high competence in the study of the Blood Brain Barrier passage.
Furthermore, we have launched two special preclinical in vivo packages with a discounted price:
- Early Safety Package to screen your compounds on safety aspects and select the best for the GLP studies
- Early Bioavailibility Package to early assess the in vivo bioavailibilty of your drug candidates
To sum up:
- Your project is in the lead optimization phase or selection.
- You want to select the right compound for GLP studies.
- You want to be focused on promising compounds.
If you see yourself in this description, Syncrosome is the right partner for you.
- Professional associations
- AAPS
- Website
- www.etap-lab.com/en/cro-services/cardiovascular
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