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QIMA BioAlternatives

QIMA BioAlternatives is listed as a small business research supplier in the Scientist.com network, with 4 sites in 1 country and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 4

Countries 1

Type of company: Small business

Antibodies

Immunodetection Use antibodies to identify a protein or antigen.

Bioimaging

Bioimaging Visualize biological process non-invasively in real time.
Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Medical Imaging Visualize and analyze internal structures in animal models or patients.

Biomarkers

Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.

Show all 29 in Biomarkers 23 more

Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Spatial Metabolomics The study of the spatial distribution and localization of metabolites within biological tissues using advanced imaging and analytical techniques.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
Whole Transcriptome Amplification Amplify total RNA from a single cell.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.

Show all 11 in Cell Culture and Characterization 5 more

Human Melanoma Cell Lines Obtain highly characterized cell lines derived from patients’ tumors for in vitro and in vivo modelling.
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.

Show all 161 services 145 more

Chemical and Compound Analysis

Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.

Clinical Consulting

Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...

Disease Models

Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.

Show all 16 in Disease Models 10 more

Dry Eye Models Measure therapeutic endpoints such as tear induction, TBUT, Schirmer strips (tear volume) and cornea staining.
Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

cDNA library construction Generate a library of recombinant cDNA clones.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Extraction Extract DNA from an original source.
In Situ Hybridization Localize specific nucleic acid targets using labeled complementary probes.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
qPCR Analysis Measure the accumulation of PCR products in real time.

Show all 10 in DNA & RNA 4 more

Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.

Effectiveness

In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

In Vitro ADME

Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.

In Vitro Assays

Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.

Show all 23 in In Vitro Assays 17 more

Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Cell-based Assay Development Develop new cell based assays or modify existing ones.
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro SPF (Sun Protection Factor) Testing Use in vitro test methods to measure the UVA protection performance of sun protection products.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.
Von Willebrand Factor Analysis Detect and classify the Von Willebrand disease sub-type.

In Vitro Pharmacology

Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
In Vitro Bone Models Measure osteoclast activity and bone formation in human or rat osteoclasts.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.

Show all 9 in In Vitro Pharmacology 3 more

In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Protease Assay Measure protease activity in biochemical and cell-based assays.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity

Model Development

Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.

Product Development

Oral Care - Manufacturing Manufacturing services for oral care products
Over-The-Counter (Other) - Manufacturing Other manufacturing services for Over-The-Counter (OTC) products
Personal Care Product Development Services including the formulation, manufacturing, or designing of a personal/consumer care product or packaging.
Personal/Consumer Care Product or Service Request relating to the creation, testing or manufacturing of a personal care/consumer health/cosmetic product, ingredient or raw material.

Protein Sciences

Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.

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Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Raw Materials

Anti Irritants Reduce the irritation potential of other more irritating ingredients in the same product.
Fillers Ingredient used to create bulk, texture or lubrication
Humectants Acquire humectants, such as glycerin, propylene glycol, and sorbitol, to use as ingredients in consumer healthcare products.
Occlusives Moisturizing agent that work by forming a protective coating on the surface of your skin

REACH Services

Hazard, Exposure and Risk Assessment Evaluate the known hazard of a test compound in conjunction with the expected quantity and frequency of exposure.
In Vitro Skin Sensitization Determine whether a drug or cosmetic product may cause dermal sensitization.
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.

Testing Services

ASTM E1207: Antiperspirant Clinical Testing Determine antiperspirant efficacy for products (e.g. deodorant) that are intended to be applied to the underarm.
Characteristic Testing Characterization of physical and chemical properties of raw materials
CLSI M26-A: Minimum Bactericidal Concentration (MBC) Determine the lowest concentration of an antimicrobial agent that is lethal to the target bacteria in vitro.
Collagen Production Test Test the regenerative ability of the skin under the influence of the test sample.
Cosmetics Aerobic Plate Count Determine the level of aerobic bacteria present in a cosmetic or personal care product.
Cosmetics Anaerobic Plate Count Determine the level of anaerobic bacteria present in a cosmetic or personal care product.

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Cosmetics Yeast and Mold Count Determine the presence of fungi in a cosmetic or personal care product.
In Vitro Claim Substantiation Evaluation using FDA Broad Spectrum and/ or ISO 24443
In Vitro Oral Care Product Testing Perform in vitro oral care product testing of dental products to evaluate safety and performance, including assessment for cleaning, brushing, whitening, stain removal, erosion, abrasivity and sensitivity.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
ISO 11930: Preservative Test Evaluate the antimicrobial stabilization of a cosmetic product as per ISO 11930.
ISO 16217: Water Resistant Testing Evaluation of sunscreen's water resistance (40 and 80 minute)
Non-Acnegenicity & Non-Comedogenicity Test Test whether a cosmetic product is likely to cause acne and comedones (pimples).
Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.
Raw Material Microbiological Testing Examples of which include Microbial Content using USP <61> and <62> and other standards, LAL Endotoxin, Ames Mutagenicity and Sterility.
Safety In-Use Studies Safety-in-use studies assess the potential for a product to elicit adverse reactions under normal use conditions.
Sebum Production Testing to evaluate the oil production in the skin
Skin Lightening Product Test Measure qualitative and quantitative changes in skin pigmentation under the influence of the test sample.
SPF Protection Efficacy Evaluation using FDA Final Rule (2011), Cosmetics Europe (COLIPA), ISO 24444
Trans-Epidermal Water Loss (TEWL) Use a sensing electrode encased in a chimney to measure the relative humidity percentage at the skin surface.
USP 51 Cosmetic Preservative Efficacy Test Evaluate the antimicrobial stabilization of a cosmetic product as per USP 51.
USP <61> Microbial Limits Test Determine whether a substance or preparation complies with an established specification for microbiological quality.
USP <62> Microbial Limits Test Determine the presence or absence of specific microorganisms.
UVA Protection Efficacy Evaluation of UVA protection using JCIA or ISO 24442

Other services

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Service areas:

Biology Pharmacology

France Gençay, Labège 4 sites

BIOalternatives, a CRO specialized in dermatology, neurobiology and inflammation, performs in vitro tests, cell-based assays, screening, and efficacy assays.

Website: qima-lifesciences.com/en/qimalifesciences-welcome

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