Volition

Volition is listed as a large business research supplier in the Scientist.com network, with 5 sites in 2 countries.

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 5

Countries 2

Type of company: Large business

Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.

In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.

Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
Recombinant Nucleosomes Use as substrates in histone methyltransferase or acetyltransferase assays.

Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
Fully Automated Assays Develop and perform assays that require no manual steps
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.

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Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.

Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity

ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.

Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.

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