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York Bioanalytical Solutions
York Bioanalytical Solutions is listed as a small business research supplier in the Scientist.com network, with 5 sites in 1 country and 3 service areas.
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Sites
5
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
- Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
- Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Biomarkers
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
- Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Show all 10 in Biomarkers
- Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
- Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Chemical and Compound Analysis
- Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Ion Exchange Chromatography Separate and detect analytes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
Show all 9 in Chemical and Compound Analysis
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Show all 65 services
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Human Biological Samples
- Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
In Vitro ADME
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Show all 23 in In Vitro ADME
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- In Vitro ADME in Vitro ADME services
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
- Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- NMR Determine molecular and protein structure, and validate sample integrity.
Show all 11 in Protein Sciences
- Protein Binding Determine drug-protein binding interactions
- Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
- Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
- Quantitative MS Quantify small and large molecules in the pg/ml range
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Service areas:
Biology
Chemistry
DMPK
Where it operates
Sites by country, with the cities in each.
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United Kingdom 5 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Unilabs York Bioanalytical Solutions is a specialist bioanalytical contract research organisation (CRO) providing a range of bioanalytical services to pharmaceutical and biotech companies, supporting the development of small and large molecule therapeutics and biomarkers, from early discovery through to post-marketing support. Our services include: Regulatory Bioanalysis Discovery Bioanalysis in vitro ADME Metabolism Bioamarkers Companion Diagnostics CoDx Project Management Specialties: Bioanalysis, LC-MS/MS, Immunoassay, Companion Diagnostics, Radioimmunoassay, Sample Logistics, Meso Scale...
Show the full description
Unilabs York Bioanalytical Solutions is a specialist bioanalytical contract research organisation (CRO) providing a range of bioanalytical services to pharmaceutical and biotech companies, supporting the development of small and large molecule therapeutics and biomarkers, from early discovery through to post-marketing support.
Our services include:
- Regulatory Bioanalysis
- Discovery Bioanalysis
- in vitro ADME
- Metabolism
- Bioamarkers
- Companion Diagnostics CoDx
- Project Management
Specialties:
Bioanalysis, LC-MS/MS, Immunoassay, Companion Diagnostics, Radioimmunoassay, Sample Logistics, Meso Scale Discovery, Discovery Bioanalysis, In vitro ADME, Metabolism
- Website
- www.yorkbio.com
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