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mfd Diagnostics GmbH

mfd Diagnostics GmbH is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.

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Type of company: Small business

Agricultural Sciences Research & Development

Bacteriology PCR and MS-Based Bacterial Identification

Animal Science and Welfare Audits

Veterinary Support Lab technician and veterinarian services providing support for model organisms and animal husbandry.
Vivarium Support Source procurement, housing, husbandry, and care of laboratory animals as well as designing, building and managing vivarium facilities.

Antibodies

Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Immunodetection Use antibodies to identify a protein or antigen.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
OmniRat Transgenic Animal Platform Produce humanized antibodies using a transgenic rat platform.

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Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Recombinant Antibody Production Request services related to antibody production services.

Bioimaging

Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.

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Peptide Bioanalysis Analyze the structure of Peptides.

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Cell Culture and Characterization

Bacterial Cell Culture Culture and Grow bacterial cells.
Cell Culture Culture primary or immortalized cell lines.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.

Chemical and Compound Analysis

Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
Stochastic Optical Reconstruction Microscopy (STORM) Visualize and localize individual fluorescent molecules.

Chemical and Compound Testing

Bacterial Water Analysis Analyzing water samples to identify the bacteria present.

Chemistry, Manufacturing and Controls (CMC)

Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Integrated Antibody Development Package-Europe Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...

Developmental and Reproductive Toxicology (DART)

Fertility and Embryonic Development Study (Segment I) - Mouse Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in mice.
Fertility and Embryonic Development Study (Segment I) - Rat Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in rats.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
Atopic Dermatitis Models Measure therapeutic endpoints in animal models of atopic dermatitis.
Auto-immune Hepatitis Models Measure therapeutic endpoints in animal models with auto-immune hepatitis.

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Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Bone Models Measure therapeutic endpoints in animal models of bone disorders.
Cartilage Repair Models Measure therapeutic endpoints in animal models of cartilage repair.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Critical Care Models Diagnose and manage life-threatening conditions requiring sophisticated organ support and invasive monitoring.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Emesis Models Measure therapeutic endpoints in animal models of emesis.
Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
IGA Glomerulonephritis Models Measure therapeutic endpoints in animal models of IgA glomerulonephritis.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Kidney Transplant Models Measure therapeutic endpoints in kidney transplant models.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Morris Water Maze Investigate spatial learning and memory in rodents.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
Osteoporosis Models Measure therapeutic endpoints in animal models of osteoporosis.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Weanling Rat Use a single animal species to create one or more disease models for anemia.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
DNA Extraction Extract DNA from an original source.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.

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Genotyping Examine a DNA sequence to identify specific genetic varients .
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.

Effectiveness

Antimicrobial Pharmacodynamics Ascertain the effectiveness of an antimicrobial compound and test levels of antibiotic resistance against specific bacterial pathogens.

Farm & Livestock Solutions

Serology/Immunology Testing for BSE/TSE

Food Safety & Regulations

Anaerobic Plate Count Determine the total anaerobic bacteria present in a food or contact-surface sample.
E.coli 0157 Tests Isolate and identify the presence of a distinct variant of the E.coli species or its potent toxin in food, water or contact-surface samples.
E.coli spp. Testing Use molecular, immunological or cultured methods to detect the presence of E.Coli species in samplings from food, water, contact surfaces or another source.
Free Coagulase Test Use a tube test to determine whether or not the S.aureus species is present in Staphylococcus isolates from a sample.
Listeria monocytogenes Tests Assess product samples or the direct contact surfaces for a specific and prevalent Listeria species capable of growth at low temperatures.
Listeria spp. Testing Use molecular, immunological or cultured methods to identify potential growth sites for all species of the Listeria genus.

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Norovirus spp. Testing Use molecular, immunological or microscopic methods to detect and quantify Norovirus species in food, water or contact-surface samples.
Pseudomonas aeruginosa Testing Use molecular, immunological or cultured methods to confirm the presence or absence of P.aeruginosa in samples from food, water or processing surfaces.
Pseudomonas spp. Testing Detect the presence and abundance of various cold-tolerant Pseudomonas species that cause or contribute to spoilage in meat, poultry, seafood, dairy or beverages.
Salmonella spp. Testing Use molecular, immunological or cultured methods to identify the presence of Salmonella species in food or contact-surface samples.
Shigella spp. Testing Use molecular, immunological or cultured methods to detect various species of Shigella in food samples.
Total Coliform Testing Measure the bacterial content of a sample to assess food safety, efficacy of sanitation methods or handling practices.

General in vivo Toxicology

Carcinogenicity Study - Mouse Conduct a repeat dose, chronic carcinogenicity study in mice to determine the tendency of your compound to produce tumors.
Carcinogenicity Study - Rat Conduct a repeat dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

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IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Other Species Conduct a repeat dose study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

In Vitro Assays

Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Microbiology Study microbes and their role in human health.

In Vitro Pharmacology

In Vitro Fertilization Models Measure oocyte maturation, embryo development in culture and sperm fertilizing ability.

In Vitro Toxicology

Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.

In Vivo Pharmacokinetics

Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.

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Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zebrafish Animal Model Model human disease and development in zebrafish.

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Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Non-Human Biospecimen

Guinea Pig Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Guinea Pig Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Guinea Pig Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Pig / Minipig / Porcine Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.

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Pig / Minipig / Porcine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Pig / Minipig / Porcine Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rabbit Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Rabbit Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Rabbit Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rat Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Rat Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Rat Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Murine Adenocarcinoma 16 (MAC16) Murine Test for therapeutic efficacy of drug candidates in muscle wasting models.
NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.

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Reproductive System PDX Patient derived xenografts relating to reproductive systems. This includes PDX from reproductive organs such as the Ovaries, Cervix, Breasts, Testes, Prostate, and Scrotum.

Protein Sciences

Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Native Protein Purification Purify native proteins from sources such as tissue & serum.
Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
Peptide Discovery Identifying and developing new peptides.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.

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Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Products Find native and recombinant proteins and peptides.
Protein Purification Isolate native or recombinant proteins from a sample.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.

Safety Pharmacology

Drug Discrimination Study - Other Species Conduct a study to investigate the length of psychoactive effects of your compound in other species and conduct dose range finding for further studies.
Drug Discrimination Study - Rat Conduct a study to investigate the length of psychoactive effects of your compound in rats and conduct dose range finding for further studies.
Jacketed External Telemetry (JET) Study - Minipig Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in minipigs.
Telemetry Use implantable or external devices to study physiological parameters in model organisms

Specialty Dosing Routes

Chronic Intranasal Carcinogenicity Study - Rats Conduct a repeat dose intranasal, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Chronic Intravenous Infusion Carcinogenicity Study - Other Species Conduct a repeat intravenous infusion dose, chronic carcinogenicity study in other species to determine the tendency of your compound to produce tumors.
Chronic Intravenous Infusion Carcinogenicity Study - Rat Conduct a repeat intravenous infusion dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Intravitreal Toxicity and/or Toxicokinetic Study - Minipig Conduct an intravitreal ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.

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Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.
Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Rat Conduct a repeat dose intranasal study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Other Species Conduct a repeat dose intravenous infusion study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Rats Conduct a repeat dose intravenous infusion study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Other Species Conduct a single dose intravenous infusion study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Rats Conduct a single dose intravenous infusion study in rats to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Minipig Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to minipigs.
Topical Dermal Toxicity and/or Toxicokinetic Study - Mouse Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to mice.
Topical Dermal Toxicity and/or Toxicokinetic Study - Other Species Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to other species.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rabbit Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rabbits.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rat Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rats.
Topical Ocular Toxicity and/or Toxicokinetic Study - Minipig Conduct a topical ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.

Testing Services

Bacterial Identification Testing Use biochemical and molecular methods to identify unknown microorganisms.
CLSI M26-A: Minimum Bactericidal Concentration (MBC) Determine the lowest concentration of an antimicrobial agent that is lethal to the target bacteria in vitro.
Microbiological Sterility Testing Test the presence of viable microorganisms.

Other services

Implantable Telemetry for Large Animals Use implantable telemetry to study physiological parameters in large animals, such as dogs, primates, swine, sheep, horses, and cattle among others.
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