Supplier site
Group of sites (click to zoom)

Scientist.com supplier network (site locations)

Research supplier

Aryastha Life Sciences

Aryastha Life Sciences is listed as a new startup research supplier in the Scientist.com network, with 2 sites in 2 countries.

View Aryastha Life Sciences on Scientist.com

Email me this page as a PDF

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 2

Type of company: New startup

Antibodies

Immunodetection Use antibodies to identify a protein or antigen.

Biomarkers

Microfluidics-Based Biomarker Isolation and Detection Isolate and detect rare biomarkers in blood samples, such as CTCs, cfDNA, and exosomes.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.

Chemical and Compound Analysis

Chiral Separation Purify therapeutically active isomers of drug candidates.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
Structural Chemistry Examine the relationship between protein structure and function.

Show all 105 services 93 more

Clinical Trials

Patient Recruitment Recruit and retain patients for clinical trials.
Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Companion Diagnostics

Cervical Cancer CDx Design and validate companion diagnostics for cervical cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Osteoarthritis CDx Design and validate companion diagnostics for osteoarthritis that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Pancreatic Cancer CDx Design and validate companion diagnostics for pancreatic cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Rheumatoid Arthritis (RA) CDx Design and validate companion diagnostics for RA that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

Data Science/Bioinformatics

Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.

Discovery Chemistry

Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.

Show all 8 in Discovery Chemistry 2 more

Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.

Disease Models

Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Recombinant Nucleosomes Use as substrates in histone methyltransferase or acetyltransferase assays.

Drug Development

Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Human Biological Samples

Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
Human Exosomes Request services related to the creation and development of human exosomes
Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.

Show all 21 in In Vitro ADME 15 more

Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro ADME in Vitro ADME services
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Human Immuno-deficiency Virus Infection CDx Design and validate companion diagnostics for HIV infection that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

In Vitro Pharmacology

High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Mass Balance Study - Minipig Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in minipigs.
Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Show all 18 in In Vivo Pharmacokinetics 12 more

Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Market Access

Market Research & Business Intelligence Run market feasibility studies, establish customer needs, improve product performance and analyze competition.

Model Development

Animal Precision-Cut Lung Slice Model Acquire a fresh phenotypically-accurate model to study animal lung behavior.
Custom Model Development Develop a custom disease model.
Disease Model Database For sourcing disease models.
Fresh Functional Human Tissue Efficacy Assays Use fresh functional human tissue to assess pre-clinical efficacy of test compounds.
Fresh Functional Human Tissue Permeability Assays Use fresh functional human tissue to assess tissue permeability with various compounds.
Fresh Functional Human Tissue Vasoconstriction Assays Use fresh functional human tissue to assess vasoconstriction with various compounds.

Show all 11 in Model Development 5 more

Fresh Functional Human Tissue Vasodilation Assays Use fresh functional human tissue to assess vasodilation with various compounds.
hTME-3DX Screen and Verify™ A sophisticated and physiologically relevant 3D model that recapitulates the patient tumor microenvironment.
Human Precision-Cut Intestinal Slice Model Acquire a fresh phenotypically-accurate model to study human intestinal behavior.
Human Precision-Cut Liver Slice Model Acquire a fresh phenotypically-accurate model to study human liver behavior.
Human Precision-Cut Lung Slice Model Acquire a fresh phenotypically-accurate model to study human lung behavior.

Oncology Models

Digestive System PDX Patient derived xenografts relating to organs and components of the digestive system. This includes, but is not limited to the Stomach, Intestines, Liver, Colon, Colorectal samples and Gastric samples.
Endocrine System PDX Patient derived xenografts related to the endocrine system. PDX related to glands controlling hormone regulation such as the Pituitary glands, Thyroid Glands, Adrenals, and Pancreas.
Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.

Show all 9 in Oncology Models 3 more

Reproductive System PDX Patient derived xenografts relating to reproductive systems. This includes PDX from reproductive organs such as the Ovaries, Cervix, Breasts, Testes, Prostate, and Scrotum.
Urinary System PDX Patient Derived Xenografts relating to organs that comprise the Urinary system. This includes, but is not limited to, samples from the Kidneys, Liver, and Bladder.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Testing Services

Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Website: www.aryastha.com

India Shameerpet, 1 site
United States Cambridge 1 site

Work with Aryastha Life Sciences on Scientist.com

For prices, more details, or to contact Aryastha Life Sciences, visit Scientist.com.

View on Scientist.com