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chrn on-chip biotechnologies B.V.
chrn on-chip biotechnologies B.V. is listed as a new startup research supplier in the Scientist.com network, with 3 sites in 1 country.
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Sites
3
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: New startup
Anatomic Pathology
- Immunohistochemistry Services Prepare, stain and label with histological and immunological reagents, then evaluate slide preparation of cells or tissue.
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Immunodetection Use antibodies to identify a protein or antigen.
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Biomarkers
- Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Show all 8 in Biomarkers
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell Culture Culture primary or immortalized cell lines.
- Custom 3D Microtissue Development Convert cell lines into highly functional 3D microtissues using scaffold-free self-assembly.
- In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
- Microphysiological system (MPS)/organoid analytics microTMA produced from fixed microtissues (MPS)
Show all 8 in Cell Culture and Characterization
- Microphysiological Systems/organoid transcriptomics Microphysiological Systems/organoid transcriptomics
- Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Show all 74 services
Clinical Consulting
- Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Companion Diagnostics
- Cervical Cancer CDx Design and validate companion diagnostics for cervical cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
- Pancreatic Cancer CDx Design and validate companion diagnostics for pancreatic cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
- Rheumatoid Arthritis (RA) CDx Design and validate companion diagnostics for RA that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Discovery Chemistry
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Disease Models
- Adjuvant-Induced Arthritis in Rat (AIA) The Adjuvant-Induced Arthritis (AIA) model in rats is a widely used preclinical tool for studying autoimmune and inflammatory joint diseases, particularly Rheumatoid Arthritis (RA)
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
- Collagen-Induced Arthritis (CIA) The Collagen-Induced Arthritis (CIA) model is the most widely used preclinical animal model for human Rheumatoid Arthritis (RA)
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
DNA & RNA
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
General in vivo Toxicology
- Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
- Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
Human Biological Samples
- Human 3D cultures Provision of 3D culture of Human Primary Cells
- Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
- Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
- Patient Derived Tumoroids 3d tumoroids generated from patient derived tumour tissue
- Tumor Cells Acquire tumor cells (either human or animal)
In Vitro ADME
- In Vitro ADME in Vitro ADME services
In Vitro Assays
- 3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
Show all 11 in In Vitro Assays
- In Vitro CAR-T Therapy Chimeric Antigen Receptor T-cell therapy: specialized form of immunotherapy
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
In Vitro Toxicology
- Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
- Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
- Cytotoxicity Test for effects on cell viability and proliferation
In Vivo ADME
- Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
In Vivo Pharmacokinetics
- Cardiac Safety Assessment Assess cardiotoxicity using microelectrode assay technology.
Model Development
- 3D Blood-Brain Barrier Model Use an in vitro 3D blood–brain barrier model for real-time visualization of cellular and barrier functions.
Oncology Models
- 3D Triculture Breast Cancer Model Use tricultures of breast cancer cell lines, hMSCs, and endothelial tubules for evaluating breast cancer progression.
- CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
- Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
- T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Safety Pharmacology
- Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Other services
- 3D Force Microscopy of Cells Measure cell-generated forces in 3D biopolymer networks that mimic the physiological situation of living cells.
- Website
- chrn.co
Where it operates
Sites by country, with the cities in each.
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Netherlands 3 sites
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