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Brain Case Biotech
Brain Case Biotech is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country.
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Agricultural Sciences Research & Development
- Gene Isolation and cloning Development of methods for isolation of gene(s) of interest.
Antibodies
- SARS-CoV-2 (COVID-19) Antibodies Search for available SARS-COV-2 antibodies
- SARS-CoV-2 (COVID-19) Protein and Antigen Search for available SARS-CoV-2 proteins and antigens
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
- In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
- In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
- In-vivo Fluorescence In-vivo fluorescence enables visualisation and the study of biological processes in live organisms by using fluorescent markers.
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Biomarkers
- Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
- Focus Forming Assay Use colorimetric or immunofluorescence-based readouts to quantify virions prior to any plaque formation.
- Islet Cell Autoantibodies (ICA) Testing Detect Type 1 diabetes-related autoantibodies.
- Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Show all 97 services
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
- RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Show all 8 in Cell Culture and Characterization
- Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.
- Virus Products Purchase virus strains
Chemical and Compound Analysis
- Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
- Optical Tomographic Imaging Use multiply-scattered light to reconstruct images of illuminated objects.
Clinical Trials
- Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.
Disease Models
- Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
- Cognition Models Measure therapeutic endpoints in animal models of cognition.
- Electroencephalogram EEG Models Record electrical activity along the scalp of animal models or human patients.
- General Pain Models Measure therapeutic endpoints in animal models of general pain.
- Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Show all 19 in Disease Models
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
- Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
- Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
- Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
- Optogenetics (rodent behavioral testing) Use light to selectively control the molecular events in cells of living organisms.
- Pain Models Test therapeutic efficacy of drug candidate in pain model.
- Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
- Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
- Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
- Stroke Models Measure therapeutic endpoints in animal models of stroke.
- Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
- Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
DNA & RNA
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
- CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
- DNA Extraction Extract DNA from an original source.
- DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
- DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
Show all 13 in DNA & RNA
- Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
- Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
- Knockout/Knockin Cell Lines Develop Knockout/Knockin Cell Line.
- Linear Based RNA Amplification Perform rapid non-PCR RNA amplificaton.
- Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
- shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
Drug Development
- Pharmacogenetics Consulting Access genomic services required for clinical trials, such as genotyping, genetic variation testing and DNA isolation.
General in vivo Toxicology
- Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
- Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
- Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Human Biological Samples
- Cell Line and Cellular Services Promotion for Cells and Cell lines
- Human Exosomes Request services related to the creation and development of human exosomes
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
In Vitro Assays
- Antivirals Measure anti-viral activity in biochemical and cell assays.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Proliferation Measure cell number, cell viability and cell division.
- Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Show all 8 in In Vitro Assays
- Viral Clearance Assays Measure the capacity to remove or inactivate infectious agents during the manufacturing process.
- Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.
In Vitro Pharmacology
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Custom Model Development Develop a custom disease model.
- Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Oncology Models
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Other Specialty Toxicology
- Viral Testing Characterize viral products for functional activity and possible contamination.
Protein Sciences
- Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
- Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
- Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
- Lentivirus Production Develop lentiviruses and production protocols.
Show all 13 in Protein Sciences
- Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Protein Labeling Find suppliers who offer attaching detectable tags like fluorophores or enzymes to proteins
- Protein Purification Isolate native or recombinant proteins from a sample.
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
- Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.
Safety Pharmacology
- CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
- Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
- Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
- Website
- www.ebraincase.com
Where it operates
Sites by country, with the cities in each.
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China 2 sites
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