PI Health Sciences

PI Health Sciences is listed as a mid sized business research supplier in the Scientist.com network, with 5 sites in 2 countries.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 5

Countries 2

Type of company: Mid sized business

Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
Impurities in API Risk assessment Create a risk-based control strategy to determine any impurities in Active Pharmaceutical Ingredients (API).
Liquid Chromatography Separate substances using a mobile and stationary phase.

Show all 11 in Chemical and Compound Analysis 5 more

Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.

Analytical Development and Validation Request services related to Analytical Development and Validation
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Crystallization studies Crystallization studies
Drug Substance and Drug Product Characterization and Manufacturing Drug Substance and Drug Product Characterization and Manufacturing.

Show all 12 in Chemistry, Manufacturing and Controls (CMC) 6 more

Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
ICH-compliant stability testing Perform ICH-compliant stability testing
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Show all 50 services 38 more

Discovery In Silico Drug Dynamics Develop In Silico model of a drug candidate with a biological system with applications such as Pro-drug Predictions, ADME-PK Due Diligence, Brain-Barrier Permeability Simulation, Drug Absorption Simulation, In Silico...

Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.

Show all 16 in Discovery Chemistry 10 more

Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.

HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro ADME in Vitro ADME services
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.

Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity

In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

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