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ProtaGene

ProtaGene is listed as a mid sized business research supplier in the Scientist.com network, with 8 sites in 2 countries and 1 service area.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 8

Countries 2

Type of company: Mid sized business

Antibodies

Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.

Show all 9 in Antibodies 3 more

Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Peptide Bioanalysis Analyze the structure of Peptides.

Cell Culture and Characterization

Endotoxin Characterization Identify specific molecular structure (e.g., Lipid A profiling), determine bacterial source/strain, and assess biological potency of endotoxins

Show all 115 services 103 more

Chemical and Compound Analysis

Accelerator Mass Spectrometry Detect trace levels of naturally-occurring radionuclides and stable nuclides.
Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.

Show all 34 in Chemical and Compound Analysis 28 more

Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
Fluorescence Mediated Tomography Visualize the spatial distribution of fluorescencently labeled probes and substances.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Ion Exchange Chromatography Separate and detect analytes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Photostability Measure drug degradation rates after exposure to various light sources.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Melting Point Analysis Assess protein stability by Differential Scanning Calorimetry (DSC) or Fluorimetry (Thermofluor) methods.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Static Light Scattering Use scattered light intensity to determine the average molecular weight of biopolymers.
Structural Spectroscopy Assess conformational transitions that proteins undergo in response to changes in their environment.
UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.

Chemical and Compound Testing

Product Testing Ensure product quality standards are met.
USP <85> Bacterial Endotoxin Test Test to detect or quantify bacterial endotoxins that may be present in or on a sample.

Chemistry, Manufacturing and Controls (CMC)

Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Clinical Trials

Clinical Research Services Determine the safety and effectiveness of medications and medical devices.

Data Science/Bioinformatics

Clinical In Silico Genomics/Transcriptomics Data Analysis A process that helps make sense of your omics data
In Silico Protein Sequence Analysis Use software to predict protein structural and functional features and secondary structure components.

Discovery Chemistry

Certified Standards Find certified standards for assays, tests and services.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.

In Vitro ADME

Reference Standards Find reference standards for assays, tests and services.

In Vitro Assays

Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Test for effects on cell viability and proliferation
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations

Other Specialty Toxicology

Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.
Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.
Viral Testing Characterize viral products for functional activity and possible contamination.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Analytical Ultracentrifugation Characterize the interactions and properties of macromolecules in solution.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.

Show all 25 in Protein Sciences 19 more

LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Identification Uncover or confirm the identity of a protein.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein mapping Interrogate the entire sequence of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Safety Pharmacology

Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
Genome Data Analysis Analyze genomic DNA, RNA and protein sequence data.
Pharmaco-genomics Genetic polymorphism contribution to inter-individual variability in drugs' responses and/or adverse events.
Software Tools Software tool for statistical analysis, data mining, genome annotation or NGS data analysis.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
USP <62> Microbial Limits Test Determine the presence or absence of specific microorganisms.

Service areas:

Biology

Germany Dortmund, Heidelberg, Heilbronn 6 sites
United States Burlington 2 sites

We use the most modern tools and technologies, having heavily invested in latest protein mass spectrometry equipment and long term staff training and development. We work best when we can partner with you. We love to get involved in the early project planning stages to help decide on the best strategies to develop and test your product. In fact, our clients often tell us that we excel at being proactive communicators. If we believe there is a better way to get you the best results whilst saving money, we’ll tell you. Whilst we are specialists in managing and delivering large, complex...

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We use the most modern tools and technologies, having heavily invested in latest protein mass spectrometry equipment and long term staff training and development.

We work best when we can partner with you. We love to get involved in the early project planning stages to help decide on the best strategies to develop and test your product.

In fact, our clients often tell us that we excel at being proactive communicators. If we believe there is a better way to get you the best results whilst saving money, we’ll tell you.

Whilst we are specialists in managing and delivering large, complex protein research projects, we are also available to perform individual pieces of work as part of your bigger project.

Website: www.protagene.com

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