PhysioGenix

Our goal at PhysioGenix is to become the world-leader in preclinical research services for studies focused on diabetes, cardiovascular disease and renal disease. Our extensive in-house capabilities combined with our world renowned expert consultants assist in providing the most comprehensive suite of solutions for all of your research needs.

Our highly skilled team has developed and delivered a wide-range of services for our valued customers. We pride ourselves in providing personalized services to a diverse range of clients, from the top pharmaceutical and biotechnology companies in the world, to exclusive, early-stage research companies. Our commitment is to work with our clients continuously in the development of customized research programs, and to carry out these projects with precision and accountability.

We specialize in cardiovascular, metabolic and renal diseases. Our preclinical research services are focused in the following fields:

• Diabetes
• Acute Kidney Injury
• Chronic Kidney Disease
• End Stage Renal Disease
• Cardiovascular Disease
• Obesity

We provide a full range of drug research services. From study design to near real-time data reporting, our clients have come to appreciate our time sensitive, personalized services. Our capabilities include:

• Bioanalytical/Analytical Sciences
• Discovery Pharmacokinetics

• Pharmacodynamics

• Drug Metabolism
• Specialized Blood Pressure Monitoring
• Echocardioraphy

Our scientists provide clients with individualized services to develop customized protocols focused on diseases of the cardiovascular, metabolic and renal systems. Our preclinical services include:

• Custom protocol development that combines the proper animal model with effective drug administrations, analysis parameters and environments (diet, housing).
• Use of standard rodent disease models such as db/db, ob/ob mouse, Zucker Diabetic Rat, Diet-Induced obese rodent models
• Surgical procedures including uninephrectomy; 5/6 nephrectomoy, cathertization of femoral, jugular and carotid vessels; implantation of osmotic pumps and telemetry devices.
• Acute and chronic drug administration by oral gavage; subcutaneous, IP, intramuscular and tail vein injections; osmotic pump implantation.
• Pharmacokinetic study design and execution

• Dose-effect and analysis, max tolerated dose, tolerance

• Bioanalytical assessment of biological samples collected throughout the course of drug administration.
• Gross necropsy that includes detection of drug-induced abnormalities, as well as organ removal and preservation for histological or molecular analysis.
• Histopathology that includes organ preservation, generation of tissue slices, staining and scoring by certified pathologists.

Our expert team of researchers also provides a myriad of specialized cardiovascular measurements including:

• Telemetry for continuous measurements of blood pressure in freely moving rodents during acute and/or chronic drug testing protocols.
• Femoral catheter implant for direct measurement of blood pressure changes during acute drug testing.
• Tail cuff for non-invasive measurements of blood pressure during chronic or acute drug testing.
• Echocardiography for measuring cardiac output, ejection fractions and cardiac dimensions during chronic or acute drug testing.

For over a decade, PhysioGenix has continually provided fast, top-quality, client based services to researchers in the fields of diabetes, cardiovascular and renal diseases.

Our services are designed to offer our clients accessibility and affordability in preclinical drug research by providing near real-time data, as well as on-going study design and flexibility to meet or exceed all of your research goals.

We strongly believe that our personalized service, low cost and high quality will benefit both you and your research objectives.

We look forward to the opportunity of working with you in the development of your specialized research study design.