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Paraza Pharma
Paraza Pharma is listed as a mid sized business research supplier in the Scientist.com network, with 4 sites in 2 countries and 1 service area.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Bioimaging
- In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Chemistry, Manufacturing and Controls (CMC)
- Advanced intermediates Sourcing advanced intermediates
Discovery Chemistry
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Show all 11 in Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
Show all 60 services
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Show all 24 in In Vitro ADME
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
In Vivo ADME
- Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
- Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
- Ocular Distribution Study - Rat Conduct a study to determine the distribution of your compound in ocular tissues of the rat.
- Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
- Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Show all 12 in In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
- Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Protein Sciences
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Protein Binding Determine drug-protein binding interactions
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Service areas:
Where it operates
Sites by country, with the cities in each.
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Canada 3 sites
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Paraza Pharma supports drug discovery by supporting lead identification through lead optimization services. We are an innovative company with an aim to significantly improve efficiency of drug discovery process from lead identification through lead optimization to development candidates. With an excellent team of highly creative drug discovery scientists trained in world reputed laboratories and deep experience in drug discovery & development from pharmaceutical companies such as Merck, Pfizer, Wyeth and Schering-Plough, we offer collaborative opportunities to provide most efficient...
Show the full description
Paraza Pharma supports drug discovery by supporting lead identification through lead optimization services.
We are an innovative company with an aim to significantly improve efficiency of drug discovery process from lead identification through lead optimization to development candidates. With an excellent team of highly creative drug discovery scientists trained in world reputed laboratories and deep experience in drug discovery & development from pharmaceutical companies such as Merck, Pfizer, Wyeth and Schering-Plough, we offer collaborative opportunities to provide most efficient solutions.
Headquartered in greater Montreal area, with state of the art laboratories housed in modern building, with excellent academic institutions and world class international airport for easy access, we provide location, talent pool and excellent communication skills to enhance effectiveness of our collaborations.
- Website
- www.parazapharma.com
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