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Research Toxicology Centre
Research Toxicology Centre is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 2 service areas.
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
- Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Biomarkers
- Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
- Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Cell Culture and Characterization
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Chemical and Compound Analysis
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Show all 44 services
Developmental and Reproductive Toxicology (DART)
- Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Disease Models
- In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
- Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
In Vitro ADME
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Model Development
- Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.
- Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
- Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Oncology Models
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Other Specialty Toxicology
- Phototoxicity Determine whether drug treatment causes light-activated toxic effects.
- United States Pharmacopeia (USP) Testing Use USP standards to ensure quality of pharmaceuticals, supplements and food ingredients.
REACH Services
- OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
- OECD 475: Mammalian Bone Marrow Chromosomal Aberration Test The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese...
- OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
- OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.
- REACH Services Assist in the registration, evaluation and authorization of chemical substances.
Safety Pharmacology
- Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
- Telemetry Use implantable or external devices to study physiological parameters in model organisms
Target Animal and Human Food Safety
- Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
- Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.
- Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.
Testing Services
- Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
- OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
- OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
Other services
- Implantable Telemetry for Large Animals Use implantable telemetry to study physiological parameters in large animals, such as dogs, primates, swine, sheep, horses, and cattle among others.
Service areas:
Biology
Toxicology
Where it operates
Sites by country, with the cities in each.
-
Italy 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Research Toxicology Centre offers mammalian toxicology, kinetic studies, bioavailability, dose studies, and histopathology.
- Website
- www.rtc.it
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