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BOC Sciences

BOC Sciences is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 1 service area.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Small business

Agricultural Sciences Research & Development

Vaccines Testing transgenic plants as promising systems for vaccine production.

Antibodies

Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.

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Pepscan Analysis Screen overlapping peptide sequences to identify linear epitopes.

Biomarkers

Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Cell Membrane Lipidomics Study the pathways and networks of membrane lipids.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.

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Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
Multiplex Circulating miRNA Assay Profile miRNAs directly from just 10 μl of crude biofluid or 0.1 ng of purified RNA.
Peptide Bioanalysis Analyze the structure of Peptides.
Protein Glycosylation Mapping Technique Map glycosylation sites in proteins using liquid chromatography and mass spectrometry.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Whole Transcriptome Amplification Amplify total RNA from a single cell.

Show all 193 services 180 more

Cell Culture and Characterization

Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Lipofection Transfection of DNA/RNA using lipofection reagents to create lipoplexes.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Single Cell DNA Sequencing Examine genetic variations in a single cell.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Impurities in API Risk assessment Create a risk-based control strategy to determine any impurities in Active Pharmaceutical Ingredients (API).

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Natural Product Libraries Find microbial, botanical and marine sources of natural products.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Photostability Measure drug degradation rates after exposure to various light sources.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Structural Chemistry Examine the relationship between protein structure and function.

Chemistry, Manufacturing and Controls (CMC)

Analgesic Active Ingredients Acquire analgesic active ingredients for making over-the-counter medicines.
Analytical Development and Validation Request services related to Analytical Development and Validation
API and Drug Product Stability Testing API and Drug Product Stability Testing.
API and Drug Product Storage and Distribution API and Drug Product Storage and Distribution.
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.

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API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
Bulk Raw Materials Acquire raw materials in large volumes at wholesale pricing.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Formulation Services Assistance when determining the look, texture, fragrance of a product with compatibility with product packaging, knowledge of competitive performance traits and product shelf life.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers
Raw Materials & Ingredients Purchase raw materials, ingredients, or chemicals for personal care, cosmetic, consumer health, and beauty products and substances.

Discovery Chemistry

Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.

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HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmaceutical Research Chemicals Acquire chemicals that are prospective new drug entities.
Polyethylene Glycols (PEGS) Acquire polyethylene glycols (PEGS) to use as ingredients in consumer healthcare products.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
UV and IR Profiling Analyze the integrity of a compound or large biomolecule.

DNA & RNA

Amplicon 16s rRNA Sequencing Identify and compare bacteria present within a given sample.
ChIP-Sequencing Use chromosome immunoprecipitation to identify DNA-protein binding sites in a genome.
ChIP-sequencing Profiling Identify where a protein is binding to DNA on a genome-wide scale.
DNA Extraction Extract DNA from an original source.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.

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DNA-lipid interaction analysis Investigate cellular dynamics based on changes in fluorescent properties.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Linear Based RNA Amplification Perform rapid non-PCR RNA amplificaton.
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
mtDNA Sequencing Use next-generation sequencing (NGS) technology to detect and analyze mitochondrial mutations.
Non-Bisulfite DNA Methylation Analysis Analyze DNA methylation by methods such as differential enzymatic cleavage or affinity capture
Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
Plant RNA Interference Inhibit the expression of specific or detrimental plant genes to enhance crop growth, yield or stress tolerance.
Plant siRNA Design Create selective and potent small interfering RNA constructs for plant gene analysis or crop improvement.
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
Poly (A) tail Length Profiling (PAL-Seq) Conduct high-throughput sequencing of individual mRNA poly (A) tails.
qPCR Analysis Measure the accumulation of PCR products in real time.
Ribosome Profiling Determine which mRNAs are being actively translated using next generation sequencing and specialized messenger RNA (mRNA)
RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
RNAi Pathway Analysis Use high-throughput RNAi genetic screens to elucidate relevant signaling pathways.
shRNA Synthesis Design shRNA constructs that produce stable knockdown of the corresponding mRNA.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
Single Molecule Real Time Sequencing Monitor the incorporation of fluorescently conjugated nucleotides within zero-mode waveguide (ZMW) chambers.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Food Safety & Regulations

Carbohydrate Testing Determine the types and concentrations of carbohydrates in foods for nutritional labeling, quality control, and for identifying possible adulteration.

In Vitro ADME

Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.
Glucose Release Assay Determine free glucose levels in biological samples.
Glycobiology Study the structure biosynthesis and biology of carbohydrates
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.

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Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.

In Vitro Pharmacology

Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
Target Characterization Characterize potential drug targets during the drug discovery process.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cytotoxicity Test for effects on cell viability and proliferation

Nanotechnology

Custom Nanostructures Fabricate materials in the form of spherical particles, nano-tubes, wires, rods, discs, flakes, prisms or dispersions.
Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.
Metal/Metal Oxide Nanoparticle Synthesis Use nanoparticles for drug and gene delivery, imaging, analyte detection, labeling and DNA structure determination.
Nanoparticle Conjugation and Functionalization Modify biomolecules to enhance structure and function.
Nanoparticle Synthesis Create nano-level structures with unique features.
Nanoporous Microspheres Nanoporous microspheres are particles with diameters in the micrometer range that can be made from various synthetic materials. Use for chromatographic separations, catalysis, energy storage, tissue engineering...

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Nanotubes and Nanowires Use nanosensors, electrical probes for biological membranes and transistors for lab-on-chip applications.
Silica/Polystyrene/Organic Nanoparticle Synthesis Synthesize nanoparticles with distinctive composition, size, shape and surface chemistry.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Processing, Packaging, & Preservation

Aerobic Fermentation Implement desirable microbial activity in oxygenated conditions to enhance or preserve food and beverage products.
Non-Alcoholic Beverage Carbonation Find commercial facilities to implement effervescent properties that enhance the formulation of non-alcoholic beverages.
Pure Culture Fermentation Implement the desirable microbial activity of a specific microbial strain to enhance or preserve food and beverage products.

Product Development

Aerosol Products - Formulation Formulation services for aerosol products (e.g. hairsprays and spray antiperspirants)
Brows/Lashes - Formulation Formulation services for brow/lash products
Makeup Removers - Formulation Formulation services for make-up removers
Men's Products - Formulation Formulation for male oriented products.
Oral Care Products - Formulation Formulation services for oral care products.
Over-The-Counter/OTC (Other) - Formulation Other formulations for Over-The-Counter (OTC) products

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Personal Care Product Development Services including the formulation, manufacturing, or designing of a personal/consumer care product or packaging.
Personal/Consumer Care Product or Service Request relating to the creation, testing or manufacturing of a personal care/consumer health/cosmetic product, ingredient or raw material.
Specialty (Other) - Formulation Other formulations for specialty products in personal care

Protein Sciences

Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
Carbohydrate Isolation Obtain pure monosaccharides, pure polysaccharides or related derivatives from samples.
Carbohydrate Isolation Protocol Development Design and optimize protocols for carbohydrate isolation.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
Immunopeptidome Profiling Identify and analyze peptides presented by MHC molecules

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Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
MAPPs (MHC-II-associated peptide proteomics) MAPPs, or MHC-II-associated peptide proteomics, is a mass spectrometry technique for identifying peptides from therapeutic proteins that are presented by MHC class II molecules on antigen-presenting cells.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
NMR Determine molecular and protein structure, and validate sample integrity.
PEG Protein Conjugation Improve the therapeutic or pharmacokinetic properties of a protein by pegylation.
Peptide Array Use biologically active synthetic peptides arranged in a high density format to assess protein interaction.
Peptide Derivatives Acquire chemicals that are peptide derivatives.
Peptide Discovery Identifying and developing new peptides.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
Phage Display Use in vitro screening method to identify protein binding partners.
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Quantitative MS Quantify small and large molecules in the pg/ml range
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
SILAC Enable incorporation of isotopic labels in proteins for mass spectrometry-based quantitative proteomics.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

Raw Materials

Adjusters Adjust the pH of a finished product with Spectrum's wide selection of cosmetic pH adjusters. These chemical ingredients maintain the stability of formulations and efficacy of the finished cosmetic or personal care...
Anti Irritants Reduce the irritation potential of other more irritating ingredients in the same product.
Cationics Positively charged surfactant molecules.
Fillers Ingredient used to create bulk, texture or lubrication
Humectants Acquire humectants, such as glycerin, propylene glycol, and sorbitol, to use as ingredients in consumer healthcare products.
Ingredient Delivery Systems Ingredients that aid in the skin penetration of other active ingredients.

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Non-Surfactant Modify the interface between solid particles and the liquid medium to improve the particles' resistance to settling.
Occlusives Moisturizing agent that work by forming a protective coating on the surface of your skin
Plasticizers Excipients designed to modify the physical properties of a basic polymer.
Surfactants - Amphoterics, Anionics, Betaines, Ethoxylated Glycerine, Nonionics Acquire surfactants, such as amphoterics, anionics, betaines, ethoxylated glycerine, and nonionics, to use as ingredients in consumer healthcare products.

Safety Pharmacology

Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.

Scientific Data Services

Small RNA Gene Expression Quantify and analyze miRNA, piRNA, siRNA as well as other small nuclear RNAs from small-RNA-seq raw input data sets.

Testing Services

Cosmetic Preservative Efficacy Test Assess the efficacy of a product's preservative system.

Other services

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Service areas:

Chemistry

United States SHIRLEY, Shirley 2 sites

BOC Sciences provides a wide variety of custom services which range from bulk compounds to specialty species in the pharmaceutical, agrochemical, and biotechnology industries. We are committed to providing our customers with the best products and services at the most competitive prices. Given diverse packing options for most of our chemicals, you are welcome to order the desired compounds in any quantities from a few mg to several kg along with all the relevant technical reports. We sincerely hope that our unremitting pursuits of excellence, success, and professionalism will add immense...

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BOC Sciences’ scientists are skilled in the latest methods in synthetic organic chemistry to work closely with clients. We ensure high quality standard and on time, in full delivery. BOC Sciences has an expertise in the design and preparation of multi-step targets on scales ranging from milligrams to kilograms. Our scientists in the chemistry team are well trained to focus efforts to evaluate the synthesis. Normally, your inquiries will be addressed within 48 hours upon receipt of request. We will offer a ballpark price and a lead time for the project in a timely manner. BOC Sciences honors its quoted price even when the project might require more work than anticipated. We won't charge our clients for failed syntheses.

BOC Sciences offers the design and synthesis of multipurpose screening compounds to meet your exact screening requirements. Specify compounds, quantities, format (dry/solid or DMSO) and the tube, vial or plate required to complement your compound handling system. We also offer one of the most powerful screening platforms in the industry with over 850,000 unique chemical compounds and approximately 100,000 probes from natural sources to suit different in capacity and assays. Each library may be screened individually or in combination with other libraries, allowing a tailored approach to HTS project requirements and the greatest coverage of chemical space to maximize the chance of finding hits. Chemical compounds in our library collections are available for re-supply from our US stock.

Customers are also welcome to provide literature methods or their own synthetic routes in which all relevant information such as reaction time, solvent, temperature, analytic data, purification method, yield, etc. is detailed. In the case where there is a lack of technical data, we are still capable of providing a rough estimate upon a careful review of the research paper. Working in state-of-the-art laboratories, equipped with the latest process and analytic instruments, BOC Sciences scientists have good experience and infrastructure to make your project a success story.

Website: www.bocsci.com

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