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Aptamer Group
Aptamer Group is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
- Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
- Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
- In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Bioimaging
- Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Biomarkers
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Show all 8 in Biomarkers
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Show all 59 services
Cell Culture and Characterization
- Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
- RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Chemical and Compound Analysis
- Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
- Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Data Science/Bioinformatics
- Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Discovery Chemistry
- Bio-Layer Interferometry Octet BLI is a label-free, real-time technology used to measure biomolecular interactions by detecting changes in optical interference patterns, offering insights into binding kinetics, affinity, and concentration.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
DNA & RNA
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- DNA Extraction Extract DNA from an original source.
- DNA Library Screening Screen genomic or cDNA libraries for positive clones.
- DNA Sequencing Determine the nucleotide sequence of DNA samples.
- DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
- DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
Show all 12 in DNA & RNA
- NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
- Nucleic Acid Hybridization Use a nucleic acid probe to identify complementary sequences.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA oligo synthesis Design and synthesize miRNAs, siRNAs and other non coding RNAs
- RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Show all 9 in In Vitro Assays
- Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
In Vitro Pharmacology
- Aptamer Products Obtain pre-made aptamers for specific target binding.
- SELEX Select and identify highly specific aptamers with binding affinities comparable to traditional antibodies.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
Protein Sciences
- Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
- Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
Show all 10 in Protein Sciences
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein Purification Isolate native or recombinant proteins from a sample.
- Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Scientific Data Services
- NGS: Next Generation Sequencing Data Analysis Use software to interpret data created by RNA-Seq, DNA-Seq, ChIP-Seq and DNA methylation experiments.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United Kingdom 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
The Aptamer group brings together various aptamer technology driven companies to provide a range of services to the life sciences industry. Over the coming decades aptamer technology will have a profound effect on the life science market helping provide more cost-effective solutions to end users. We aim to address market needs through our group which has companies specialising in: the provision of high quality R&D consumables and high throughput aptamer screening services through Aptasol, biomarker discovery and validation tools (Aptasort), diagnostics devices / reagents (Aptadx)...
Show the full description
The Aptamer group brings together various aptamer technology driven companies to provide a range of services to the life sciences industry. Over the coming decades aptamer technology will have a profound effect on the life science market helping provide more cost-effective solutions to end users. We aim to address market needs through our group which has companies specialising in: the provision of high quality R&D consumables and high throughput aptamer screening services through Aptasol, biomarker discovery and validation tools (Aptasort), diagnostics devices / reagents (Aptadx) and therapeutic lead compounds (Aptarx).
Custom aptamer development (Aptasol)
Aptamer Solutions provides bespoke services to the life sciences sector including the development and manufacture of DNA and RNA aptamers as alternatives to antibodies. Aptamer Solutions was founded in March 2008 by Dr Arron Tolley and Dr David Bunka in order to address several key areas in the life sciences market that were unfilled by monoclonal or polyclonal antibodies. Our high-throughput aptamer selection processes, combined with a customised suite of high throughput liquid handling robotics, allows us to offer a fully automated, rapid and consistent approach to aptamer development. Aptamer Solutions offers the perfect solution for new projects or for the revisiting of past antibody projects that have failed or yielded unsatisfactory results.
Aptamer Integration / Diagnostics development (Aptadx)
Aptamer Diagnostic is a contract research organisation created to respond to the need for faster, more accurate and more diverse and diagnostic reagents with a longer shelf-life. We specialise in the development and modification of aptamers specifically for use in a wide range of different diagnostics / detection platforms. Aptamers are a natural investment for customers who wish to diversify their product portfolio, develop a new line of products, extend the shelf life of existing products, truly immortalise their product line, limit batch to batch variability with their reagents, reduce development and production costs and simplify their existing assays.
Aptamer Therapeutics (Aptarx)
Aptamer Therapeutics specialises in the development of nucleic acid aptamers as candidate molecules for therapeutic applications.The ability of aptamers to specifically target a protein, protein domain, cell or tissue type etc is not only of interest for diagnostic developments; they are now being developed for their potential uses in therapeutics There are several avenues for exploitation of aptamers as therapeutics.
Aptamers can be:
- used directly as therapeutic agents
- used to form part of a therapeutic chimera
- used to serve as a carrier for other therapeutic agents or
- used to modulate the activity of a therapeutic agent
Aptarx are currently developing aptamers for use as therapeutics with several partners.
Biomarker Discovery (Aptasort)
Aptasort have combined a biomarker enrichment process with our aptamer isolation protocols yielding a first-in-kind discovery process.Our proprietary aptamer based biomarker discovery platform and proprietary combinatorial libraries contain up to and over 1018 different molecules, this diversity and bespoke library design is fundamental to the success of the screening process. This technology enables us to greatly speed up the identification of novel biomarkers as well as diagnostics and/or therapeutic candidate molecules. This technology builds on one of the most powerful uses of aptamer technology, which is the ability for aptamers to be isolated against targets without any prior knowledge of the target. Aptasort is currently validating its biomarker discover platform with several collaborators and is keen to collaborate with the pharmaceutical industry during the testing phase of the technology.
- Website
- www.aptamergroup.com
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