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Reading Scientific Services Ltd (RSSL)

Reading Scientific Services Ltd (RSSL) is listed as a mid sized business research supplier in the Scientist.com network, with 1 site in 1 country and 4 service areas.

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Sites 1

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Type of company: Mid sized business

Agricultural Sciences Research & Development

Bacteriology PCR and MS-Based Bacterial Identification
Chemical and Physical Determination of chemical and physical properties of pesticide product.

Antibodies

Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Protein De Novo Sequencing Sequence antibody proteins using multiple enzyme digestion and high-resolution LC-MS/MS.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Epitope Mapping Map the antibody-antigen binding region to define protein-protein interaction sites.

Show all 8 in Antibodies 2 more

Immunodetection Use antibodies to identify a protein or antigen.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Protein Glycosylation Mapping Technique Map glycosylation sites in proteins using liquid chromatography and mass spectrometry.

Show all 7 in Biomarkers 1 more

Proteocarta™ HCP Detect Services Identify and track host cell proteins (HCP) with mass spectrometry for higher sensitivity and coverage.

Show all 193 services 176 more

Cell Culture and Characterization

Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.

Chemical and Compound Analysis

Adsorption/Desorption Studies Obtain data on groundwater risk assessment.
Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Atomic Absorption Analysis Measure the elemental composition of a diverse array of samples.
Centrifugal Precipitation Chromatography Separate analytes based on their solubility in ammonium sulfate solution.

Show all 58 in Chemical and Compound Analysis 52 more

Chemical Stability Measure the stability of small molecules in solution.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.
Computed Tomography Visualize the internal features of solid objects.
Denaturing High Performance Liquid Chromatography Separate mixtures of denatured and reannealed oligos to identify single nucleotide substitutions, deletions and insertions.
Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Energy Dispersive X-ray Spectroscopy Identify and estimate the elemental composition of a sample based on x-ray emission patterns.
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
GC MS Analysis Use gas chromatography coupled to mass spectrometry to analyze compound integrity.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Inductively Coupled Plasma (ICP) Analysis Characterize ultra-small levels of multiple solid analytes simultaneously.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Ion Exchange Chromatography Separate and detect analytes.
Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
Nano-High Performance Liquid Chromatography Separate and detect low levels of analytes.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Optical Tomographic Imaging Use multiply-scattered light to reconstruct images of illuminated objects.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Photostability Measure drug degradation rates after exposure to various light sources.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Melting Point Analysis Assess protein stability by Differential Scanning Calorimetry (DSC) or Fluorimetry (Thermofluor) methods.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Raman Spectroscopy Use spectroscopic technique to observe vibrational, rotational and other low-frequency modes in a system.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Solution Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solution samples.
Static Light Scattering Use scattered light intensity to determine the average molecular weight of biopolymers.
Structural Chemistry Examine the relationship between protein structure and function.
Structural Elucidation Determine chemical structure of a compound. Characterization techniques include mass spectrometry, infrared spectroscopy and X-ray crystallography.
Structural Spectroscopy Assess conformational transitions that proteins undergo in response to changes in their environment.
Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.
UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.
X-Ray Fluorescence (XRF) Identify and quantify the elemental composition of solid and liquid samples.
X-ray Photoelectron Spectroscopy (XPS) Analyze the surface composition and chemistry of ultra-thin layers of a sample.

Chemical and Compound Testing

Bacterial Water Analysis Analyzing water samples to identify the bacteria present.
Limulus Amebocyte Lysate (LAL) Test Detect bacterial endotoxins in raw materials used for the production of cosmetics products.
Nutritional Testing Analyze food safety, vendor specifications, foreign substance identification processes and nutritional labeling.
USP <2021> Microbial Enumeration Tests Estimate the total aerobic microbial count, total combined yeast and mold counts, and the presence of bile-tolerant gram-negative bacteria present in nutritional supplements.
USP <2022> Microbiological Procedures for Absence of Specified Microorganisms Determine the absence of objectionable organisms in nutritional supplements.
USP <85> Bacterial Endotoxin Test Test to detect or quantify bacterial endotoxins that may be present in or on a sample.

Chemistry, Manufacturing and Controls (CMC)

Analgesic Active Ingredients Acquire analgesic active ingredients for making over-the-counter medicines.
Analytical Development and Validation Request services related to Analytical Development and Validation
Antimalarial Active Ingredients Acquire antimalarial active ingredients for making over-the-counter medicines.
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services

Show all 18 in Chemistry, Manufacturing and Controls (CMC) 12 more

Compendial test methods Run Compendial test methods (e.g., KF)
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Emulsifiers & Solubilizers Acquire emulsifiers and solubilizers to use as ingredients in consumer healthcare products.
Flow Agents Acquire flow agents, such as aluminum stearate, calcium stearate, and zinc stearate, to use as ingredients in consumer healthcare products.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
ICH-compliant stability testing Perform ICH-compliant stability testing
ISO Testing Services for Quality Assessments Testing Services follow standards developed by the International Organization for Standardization (ISO), ensuring consistency, accuracy, and international comparability in various industries including manufacturing...
Medical Device Manufacturing Prototyping and Short run production
Phosphates Acquire phosphates to use as ingredients in consumer healthcare products.
Product Insert Packaging Use product insert or leaflets to inform patients, satisfy regulatory requirements or extend a coupon offer.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Thermo Scientific iCAP Q ICP-MS Expand your analytical capabilities with this complete trace elemental analysis solution for your high-throughput lab.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.

Developmental and Reproductive Toxicology (DART)

Bioelectronics Evaluate an application (e.g. device) that integrates biological materials and micro and nano-electronics.

Discovery Chemistry

Certified Standards Find certified standards for assays, tests and services.
Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Leachable and extractable testing Leachable and extractable testing
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.

Show all 9 in Discovery Chemistry 3 more

Polyethylene Glycols (PEGS) Acquire polyethylene glycols (PEGS) to use as ingredients in consumer healthcare products.
Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
UV and IR Profiling Analyze the integrity of a compound or large biomolecule.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
DNA Extraction Extract DNA from an original source.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
Genotyping Examine a DNA sequence to identify specific genetic varients .
Metagenomic Sequencing Sequence genetic material recovered directly from environmental samples
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.

Show all 9 in DNA & RNA 3 more

qPCR Analysis Measure the accumulation of PCR products in real time.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Effectiveness

Laboratory Dose Confirmation Studies Conduct in vivo studies to confirm the effectiveness of a selected drug dose in the lab.
Laboratory Dose Determination Studies Compare the effectiveness of three non-zero therapeutic concentrations for various durations to a non-medicated control group, and a non-medicated uninfected control group.

Food Safety & Regulations

FDA Food Nutrition Facts Label Testing Analyze a food or dietary product for food labelling purposes as required by the FDA or USDA.
Water Activity Determine water activity in consumer healthcare products involving a USP or FCC monograph.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Proliferation Measure cell number, cell viability and cell division.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.

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Viral Clearance Assays Measure the capacity to remove or inactivate infectious agents during the manufacturing process.
Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.

Medical Communications

Medical Devices Biological Evaluation Report Audit Conduct a bio-compatibility evaluation of medical devices within the human body.
Toxicology Reports Create pre-clinical toxicology reports.

Nanotechnology

Nanoporous Microspheres Nanoporous microspheres are particles with diameters in the micrometer range that can be made from various synthetic materials. Use for chromatographic separations, catalysis, energy storage, tissue engineering...

New Product Development

Vitamins Analysis Analyze vitamins in foods and dietary supplements either by HPLC or titration.

Other Specialty Toxicology

Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Raw Materials Testing Verify that raw materials are sterile and not contaminated by mycoplasma, virus or other microorganisms.
Residual DNA Analysis Measure contaminants found in therapeutics like biologicals and biosimilars that are produced in cells.
United States Pharmacopeia (USP) Testing Use USP standards to ensure quality of pharmaceuticals, supplements and food ingredients.

Pharmacovigilance

GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.

Protein Sciences

Carbohydrate Isolation Obtain pure monosaccharides, pure polysaccharides or related derivatives from samples.
Carbohydrate Isolation Protocol Development Design and optimize protocols for carbohydrate isolation.
Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
Cytokines Find recombinant cytokines or cytokine assays.
Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.

Show all 22 in Protein Sciences 16 more

LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
NMR Determine molecular and protein structure, and validate sample integrity.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Binding Determine drug-protein binding interactions
Protein Identification Uncover or confirm the identity of a protein.
Protein mapping Interrogate the entire sequence of a protein.
Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Protein Purification Isolate native or recombinant proteins from a sample.
Protein Sequencing Determine the amino acid sequence of protein or peptide.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
Qualitative MS Perform direct identification of molecules based on mass-to-charge ratio and fragmentation patterns.
Quantitative MS Quantify small and large molecules in the pg/ml range
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Raw Materials

Antimicrobial Active Ingredients Acquire antimicrobial active ingredients for making consumer healthcare products.
Humectants Acquire humectants, such as glycerin, propylene glycol, and sorbitol, to use as ingredients in consumer healthcare products.
Ophthalmic Active Ingredients Acquire ophthalmic active ingredients for making vision care products.
Oral Discomfort Relief Active Ingredients Acquire oral discomfort relief active ingredients for making consumer healthcare products.
Sedative Active Ingredients Acquire sedative active ingredients for making over-the-counter medicines.
Surfactants - Amphoterics, Anionics, Betaines, Ethoxylated Glycerine, Nonionics Acquire surfactants, such as amphoterics, anionics, betaines, ethoxylated glycerine, and nonionics, to use as ingredients in consumer healthcare products.

Show all 9 in Raw Materials 3 more

Topical Alcohol Ingredients Acquire isopropyl alcohol as an ingredient for making consumer healthcare products.
Topical Analgesic Active Ingredients Acquire topical analgesic active ingredients for making consumer healthcare products.
Vitamins and Derivatives Acquire vitamins and derivatives to use as ingredients in consumer healthcare products.

REACH Services

REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Regulatory Consulting

Toxicology Data Review Identify relevant toxicological endpoints for “No Observed (Adverse) Effect Level” (NO(A)EL) or “Lowest Observed (Adverse) Effect Level” (LO(A)EL).

Scientific Data Services

Metagenomics Data Analysis Deconvolute the genetic content of genomes contained in environmental samples by utilizing whole genome sequencing techniques to provide insight into microbial communities and host phenotypes.
Molecular Phylogenetics Analyze hereditary molecular differences in genomic sequences to compare genomes.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Bacterial Identification Testing Use biochemical and molecular methods to identify unknown microorganisms.
Characteristic Testing Characterization of physical and chemical properties of raw materials
Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.

Show all 13 in Testing Services 7 more

ISO 11930: Preservative Test Evaluate the antimicrobial stabilization of a cosmetic product as per ISO 11930.
Microbiological Sterility Testing Test the presence of viable microorganisms.
Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
Raw Material Microbiological Testing Examples of which include Microbial Content using USP <61> and <62> and other standards, LAL Endotoxin, Ames Mutagenicity and Sterility.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
USP <61> Microbial Limits Test Determine whether a substance or preparation complies with an established specification for microbiological quality.
USP <62> Microbial Limits Test Determine the presence or absence of specific microorganisms.

Other services

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Service areas:

Chemistry Toxicology Clinical Consulting

United Kingdom Wokingham 1 site

Reading Scientific Services Ltd (RSSL) provides scientific consultancy in alnalysis, research, product development, and training in food, drink, pharmaceutical, healthcare, biopharmaceutical, and consumer good sectors.

Website: www.rssl.com

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