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RG Discovery AB
RG Discovery AB is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Bioimaging
- Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.
Biomarkers
- Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Show all 20 in Biomarkers
- Complete Metabolic Panel Testing Detect electrolyte or glucose imbalance to identify or monitor related disorders.
- Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
- Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
- Peptide Bioanalysis Analyze the structure of Peptides.
- Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
- Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Chemical and Compound Analysis
- Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- Structure Determination Determine the three-dimensional structure of proteins in the presence or absence of ligands.
Show all 65 services
Clinical Consulting
- Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Discovery Chemistry
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
DNA & RNA
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA Amplification Produce RNA from pre-clinical and clinical samples for use in gene expression studies.
Drug Development
- Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
In Vitro ADME
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
In Vitro Assays
- Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Show all 9 in In Vitro Assays
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
In Vitro Pharmacology
- Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
Lab Supplies, Facilities, and Equipment
- Biobanking Store and track biological samples.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Peptide Derivatives Acquire chemicals that are peptide derivatives.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Protein Binding Determine drug-protein binding interactions
- Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
- Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Show all 8 in Protein Sciences
- Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
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Sweden 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Red Glead Discovery offers drug discovery services for medicinal chemistry, synthesis of peptides and small molecules, radiolabelling, isotope labelling, assay development & screening, in vitro ADME, bioanalysis, physicochemical characterisation and NMR. We can deliver new solutions to challenging problems based on our strong knowledge and cross-disciplinary working experiences. Chemistry services (view pdf with details Medicinal Chemistry Custom synthesis incl challenging routes and parallel chemistry. Purification Compound quality control by LC-UV, LC-MS, LC-MS/MS, GC-MS Quantification...
Show the full description
Red Glead Discovery offers drug discovery services for medicinal chemistry, synthesis of peptides and small molecules, radiolabelling, isotope labelling, assay development & screening, in vitro ADME, bioanalysis, physicochemical characterisation and NMR. We can deliver new solutions to challenging problems based on our strong knowledge and cross-disciplinary working experiences.
Chemistry services (view pdf with details
- Medicinal Chemistry
- Custom synthesis incl challenging routes and parallel chemistry.
- Purification
- Compound quality control by LC-UV, LC-MS, LC-MS/MS, GC-MS
- Quantification, purity, aggregation, solubility, chemical stability
- Structure determination
Isotope-labeling of organic compounds and peptides
- Radioactive isotopes: 3H, 14C , 32P, 35S
- Stable isotopes: 2H, 13C
- Analysis methods: Specific activity, radiochemical and UV purity, 3H NMR
Assay development and screening services (view pdf with details
- Biochemical and cell assays for a wide range of targets
- Assay formats adjusted to your specific needs
- Rapid and efficient service
in vitro ADME and physicochemical characterisation (view pdf with details
- in vitro metabolism
- Bioanalysis using LC-MS/MS
- Solubility (solid samples or DMSO solutions)
- Lipophilicity (logD, logP)
- Acidity/basicity (pKa determination)
NMR services
- 1H/3H/13C/15N/19F/31P NMR
- Quantification and purity analyses
- Chemical structure identification of organic molecules and peptides
- Metabolite and impurity identification
- Studies of 3D conformation and dynamic phenomena
- Protein-ligand interactions and fragment screening
- Protein-NMR – structure, binding and dynamics
Peptide chemistry services in collaboration with Pepticon
- Fully automated microwave assisted peptide synthesis
- Labelling with stable and radioisotopes (1H, 3H, 13C, 14C , 32P, 35S)
- Quality analysis confirming chemical identity, amino acid sequence and amino-specific modifications
- Quantitative NMR for accurate peptide concentration determination
- Studies of 3D conformation and dynamic phenomena
- Website
- www.rgdiscovery.com
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