California Stem Cell

California Stem Cell provides high purity human neuron and cardiac cells. For the clinical development of treatments for metastatic cancers.

California Stem Cell, in partnership with Hoag Memorial Hospital, is developing a clinical program for the treatment of metastatic melanoma. The central concept behind this treatment is immunization against cancer stem cells. The patient’s own purified and irradiated cancer cells are combined with specialized immune cells, educating the immune cells to destroy the cancer stem cells from which tumors arise.

The process was developed during three clinical trials conducted over 15 years, which comprised two phase I-II trials followed by a randomized phase II trial. That most recent clinical trial in metastatic melanoma patients demonstrated significantly improved overall survival and time to recurrence, with 2-year survival of vaccine treated patients tracking at 67%[1], far exceeding that of any other current treatments. The clinical trials program lays the groundwork for what could potentially be effective treatments for melanoma and other terminal cancers such as liver, ovarian, pancreatic, glioblastoma, non-small cell lung cancer, and breast cancer.