- Supplier site
- Group of sites (click to zoom)
Scientist.com supplier network (site locations)
Research supplier
Frontage Laboratories
Frontage Laboratories is listed as a large business research supplier in the Scientist.com network, with 12 sites in 4 countries and 3 service areas.
View Frontage Laboratories on Scientist.com
Email me this page as a PDF
Sign in to Scientist.com to open this supplier in your organization's marketplace.
Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.
Sites
12
Countries
4
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Antibodies
- AlphaLISA Quantification of analytes with high sensitivity, wider dynamic range and no wash steps involved.
- Antibody Therapy Efficacy In vivo assessment of monoclonal/bispecific antibody efficacy in a humanized mouse
Bioimaging
- In Vivo Imaging In-vivo imaging using PET, MRI, CT etc.
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Biomarkers
- Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Show all 16 in Biomarkers
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
- Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- TUNEL Assay Detect in situ DNA fragmentation.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- H & E Services For requesting services related to H&E Services
Show all 8 in Cell Culture and Characterization
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Show all 95 services
Chemical and Compound Analysis
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Chemical and Compound Testing
- Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Clinical Trials
- Central Laboratory Services A centralized facility that handles the processing and analysis of samples collected from multiple sites in a study.
- Clinical Lab Services Comprehensive testing, analysis, and research support for a medical study.
Data Science/Bioinformatics
- Discovery Compound Screening Analytics Screening of an entire compound library directly against the drug target or in a more complex assay.
Discovery Chemistry
- Natural Product Screening Screen large natural product collections for therapeutic activity.
- Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Disease Models
- Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
- Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
DNA & RNA
- CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Drug Metabolism and Pharmacokinetics (DMPK)
- Biomarkers DMPK Biomarker DMPK and gene analysis services are critical tools in evaluating patients and discovery of new therapeutics.
Human Biological Samples
- Cell Line and Cellular Services Promotion for Cells and Cell lines
In Vitro ADME
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Multidrug Resistance Identify potential causes of drug-drug interactions.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
In Vitro Assays
- Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
- Assay Development Construct or create new assays or modify existing ones.
- BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Show all 15 in In Vitro Assays
- Cell Proliferation Measure cell number, cell viability and cell division.
- Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
- ELISpot Assay and Testing Detect low levels of antigens.
- HTS Assay Development Develop assays to use in high throughput screening.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Lab Supplies, Facilities, and Equipment
- Biobanking Store and track biological samples.
Model Development
- Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
- Pseudopregnant CD1 Mouse Use a single animal species to create gene-modified mouse models.
- SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
- Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Product Development
- Men's Products - Formulation Formulation for male oriented products.
- Oral Care - Manufacturing Manufacturing services for oral care products
- Oral Care Products - Formulation Formulation services for oral care products.
- Over-The-Counter (Other) - Manufacturing Other manufacturing services for Over-The-Counter (OTC) products
- Over-The-Counter/OTC (Other) - Formulation Other formulations for Over-The-Counter (OTC) products
- Specialty (Other) - Formulation Other formulations for specialty products in personal care
Protein Sciences
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
- Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.
- FRET/BRET Detect the location of proteins in living cells and their ability to interact with other proteins.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Protein Binding Determine drug-protein binding interactions
Show all 8 in Protein Sciences
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Other services
- New Request
Service areas:
Biology
Chemistry
Pharmacology
Where it operates
Sites by country, with the cities in each.
-
United States 9 sites
-
Canada 1 site
-
China 1 site
-
Italy 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Frontage Laboratories provides preclinical pharmacology, DMPK, bioanalytical/biomarker services, and CMC services including immunoassay development, bioanalytical method development/validation/GLP analysis, organic synthesis and GMP API manufacture, formulation development and GMP clinical trial materials manufacturing, analytical method development/validation/GMP sample analysis. Frontage also offers consulting services, such as clinical pharmacology, CMC regulatory consult, and GMP auditing and training.
- Website
- www.frontagelab.com
Work with Frontage Laboratories on Scientist.com
For prices, more details, or to contact Frontage Laboratories, visit Scientist.com.
Sign in to Scientist.com to open this supplier in your organization's marketplace.