Supplier site
Group of sites (click to zoom)

Scientist.com supplier network (site locations)

Research supplier

BioMed Linkage Tech Co., Limited

BioMed Linkage Tech Co., Limited is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 2 countries.

View BioMed Linkage Tech Co., Limited on Scientist.com

Email me this page as a PDF

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 2

Type of company: Mid sized business

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
Antibody Detection Quantitate, localize and visualize proteins and other antigens.
Antibody Discovery Identifying and developing antibodies that specifically bind to target antigens for therapeutic or diagnostic use.
Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
Antibody Isotype Switching Modify antibody isotypes from any species to any human IgG isotype.

Show all 24 in Antibodies 18 more

Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
Antibody Reformatting Re-configure antigen binding regions into soluble antibody fragments or full-length monoclonal antibodies.
Antibody Therapy Efficacy In vivo assessment of monoclonal/bispecific antibody efficacy in a humanized mouse
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Immunodetection Use antibodies to identify a protein or antigen.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Integrated Antibody Development Package-US Process an entire Antibody Development Pipeline Project including: Antigen Synthesis, Antibody Generation, Antibody Characterization, Antibody Modification, Antibody Purification, Antibody Products from our bundle...
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.
Recombinant Antibody Fragment Use alternative antibody scaffolds with smaller size, greater stability and higher yields.
Recombinant Antibody Production Request services related to antibody production services.

Bioimaging

In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.

Show all 15 in Biomarkers 9 more

Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Lipoprotein Associated Phospholipase A2 Testing Assess vascular inflammation and determine the risk for atherosclerosis or arterial plaque rupturing.
Oxidized Low Density Lipoproteins (LDL) Testing Identify the risk for metabolic syndrome and the development of associated diseases.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
TUNEL Assay Detect in situ DNA fragmentation.

Show all 331 services 318 more

Cell Culture and Characterization

H & E Services For requesting services related to H&E Services
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.

Chemical and Compound Analysis

Accelerator Mass Spectrometry Detect trace levels of naturally-occurring radionuclides and stable nuclides.
Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Computed Tomography Visualize the internal features of solid objects.

Show all 28 in Chemical and Compound Analysis 22 more

Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
Gas Chromatography Gas chromatography is an analytical technique that separates, identifies, and quantifies compounds in a mixture
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Ion Exchange Chromatography Separate and detect analytes.
Lipid Nanoparticle (LNP) Characterization Lipid nanoparticle (LNP) characterization is the process of comprehensively analyzing the physical and chemical properties of LNPs and their components to understand their structure, quality, and functionality
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
Physicochemical Analysis Physicochemical Analysis of material or preparation evaluating (e.g.) particle size, composition, or compound structure.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Solid State Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solid samples.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Spray Drying Convert a liquid into a powder by rapidly drying the mixture and removing the moisture component.

Chemistry, Manufacturing and Controls (CMC)

Analytical Development and Validation Request services related to Analytical Development and Validation
API and Drug Product Stability Testing API and Drug Product Stability Testing.
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.

Show all 22 in Chemistry, Manufacturing and Controls (CMC) 16 more

Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Crystallization studies Crystallization studies
Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Drug Substance and Drug Product Characterization and Manufacturing Drug Substance and Drug Product Characterization and Manufacturing.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
Formulation Services Assistance when determining the look, texture, fragrance of a product with compatibility with product packaging, knowledge of competitive performance traits and product shelf life.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
ISO Testing Services for Quality Assessments Testing Services follow standards developed by the International Organization for Standardization (ISO), ensuring consistency, accuracy, and international comparability in various industries including manufacturing...
LNP (lipid nanoparticle) Technology LNP (lipid nanoparticle) technology is a non-viral delivery system that encapsulates fragile genetic material like mRNA or siRNA in microscopic fat bubbles to transport it safely into cells
Medical Device Manufacturing Prototyping and Short run production
Milling, grinding, spray-drying Milling, grinding, spray-drying
Polysorbate Degradation Risk Assessment Evaluate the risk of polysorbate (PS20/PS80) degradation in biologic drug products by identifying enzymatic (residual host cell lipase/esterase) and oxidative degradation pathways and free fatty acid particle...
Powder Blending Use automatic or semi-automatic powder blending machinery to produce consistent mixes.
Powder Filling Use manual, automatic or semi-automatic machinery to package a variety of powder and granules.
Tablet Manufacturing Use automatic or semi-automatic machinery to create various standard and non-standard tablets.

Clinical Trials

BioAnalytical Laboratory Services Bioanalytical laboratory services provide essential testing to quantify drugs, metabolites, and biomarkers in biological samples (blood, urine, tissue) to support preclinical and clinical drug development
Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Data Science/Bioinformatics

Discovery Biomarker Analytics An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.

Developmental and Reproductive Toxicology (DART)

Embryo-Fetal Development (EFD) Study (Segment II) - Other Species Conduct a study to determine the effect of compound exposure on the pregnant animal and the developing fetus.
Embryo-Fetal Development (EFD) Study (Segment II) - Rat Conduct a study to determine the effect of compound exposure on the pregnant rat and the developing fetus.
Fertility and Embryonic Development Study (Segment I) Test drug candidate in Segment I toxicology services.
Fertility and Embryonic Development Study (Segment I) - Mouse Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in mice.
Fertility and Embryonic Development Study (Segment I) - Other Species Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in other species.
Fertility and Embryonic Development Study (Segment I) - Rat Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in rats.

Show all 11 in Developmental and Reproductive Toxicology (DART) 5 more

In Vitro Alternative Model for Assessing Reproductive Toxicity Laboratory-based methods used to evaluate the potential harmful effects of substances on reproduction without using live animals.
Juvenile Toxicity Study - Rat Conduct a study to determine the differences in toxicity between immature and mature systems in rats.
Pre/Post-Natal Development (PPND) Study (Segment III) - Mouse Conduct a study to quantify the effect of your compound on fetal development, parturition, and post-natal development in mice.
Pre/Post-Natal Development (PPND) Study (Segment III) - Other Species Conduct a study to quantify the effect of your compound on fetal development, parturition, and post-natal development in other species.
Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Discovery Chemistry

Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...

Disease Models

5XFAD Mice for Alzheimer’s Disease (AD) The 5XFAD mouse is a popular transgenic Alzheimer's disease (AD) model that overexpresses mutant human APP and PSEN1 with five familial AD mutations
6-OHDA-Induced Parkinson’s Disease (PD) The 6-OHDA (6-hydroxydopamine) model is a classic, widely used preclinical animal model for studying Parkinson’s Disease (PD)
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Adjuvant-Induced Arthritis in Rat (AIA) The Adjuvant-Induced Arthritis (AIA) model in rats is a widely used preclinical tool for studying autoimmune and inflammatory joint diseases, particularly Rheumatoid Arthritis (RA)
AMLN/GAN Diet-Induced NASH The AMLN (Amylin Liver NASH) and GAN (Gubra Amylin NASH) are industry-standard diet-induced animal models used to study metabolic dysfunction-associated steatohepatitis (MASH/NASH)
Atherosclerosis Model in ApoE KO Mice The Apolipoprotein E knockout ApoE KO or Apoe mouse model is the most widely used mammalian model for studying human atherosclerosis.

Show all 35 in Disease Models 29 more

Blood Models Test for therapeutic efficacy of drug candidates in blood disorder models.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Comparative Pharmacology Compare drug responses across species for improved reliability in translational studies.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
HFD + CCl4-Induced NASH The HFD + CCl4-induced NASH model combines a high-fat diet and carbon tetrachloride injections to rapidly simulate human non-alcoholic steatohepatitis (NASH/MASH)
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
MPTP-Induced Parkinson’s Disease (PD) The MPTP-induced Parkinson’s disease (PD) model is a chemically induced animal model widely used in neurobiological research
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ob/ob Mouse Use a single animal species to create one or more disease models obesity and angiogenesis.
Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Obese Primates Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
SNI Neuropathic Pain The Spared Nerve Injury (SNI) model is a widely used rodent model of peripheral neuropathic pain
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
mRNA synthesis Transcribe mRNAs in vitro and add modifications such as polyadenylation and guanine capping.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.

General in vivo Toxicology

Carcinogenicity Study - Mouse Conduct a repeat dose, chronic carcinogenicity study in mice to determine the tendency of your compound to produce tumors.
Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
Repeat Dose Toxicity Study - Monkey / Non-human Primate Conduct a repeat dose study in monkey/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Show all 9 in General in vivo Toxicology 3 more

Single Dose Acute Toxicity Study - Monkey / Non-human Primate Conduct a single dose study in Monkeys and Non-human Primates to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Custom PDX models For requesting Custom PDX models

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.

Show all 17 in In Vitro ADME 11 more

Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro ADME in Vitro ADME services
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.

In Vitro Assays

Anti-thrombin Assays Use clotting and chromogenic assays to detect and classify anti-thrombin deficiency.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.
ELISpot Assay and Testing Detect low levels of antigens.

Show all 10 in In Vitro Assays 4 more

Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
Lipid Detection Use in vitro methods to identify lipid droplets and any associated proteins.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
Thrombin Generation Tests Measure the tendency of a plasma sample to form thrombin upon the initiation of coagulation.

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
Syngeneic Tumor Model A syngeneic tumor model is a preclinical cancer research model in which immortalized murine (mouse) cancer cell lines are implanted into genetically identical, immunocompetent mice.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Cytotoxicity Test for effects on cell viability and proliferation
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations

Show all 10 in In Vitro Toxicology 4 more

HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.

In Vivo ADME

Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine Conduct a bile duct cannulation (BDC) study in dogs/canines to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Monkey / Non-human Primate Conduct a bile duct cannulation (BDC) study in monkeys/non-human primates to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Other Species Conduct a bile duct cannulation (BDC) study in other species to support the absorption, distribution, metabolism and excretion profiling of your compound.
In Vivo Radiolabeled Metabolism Determine the qualitative and quantitative metabolism and/or degradation of an active ingredient in animals.
Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.

Show all 8 in In Vivo ADME 2 more

Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
Ocular Distribution Study - Rat Conduct a study to determine the distribution of your compound in ocular tissues of the rat.

In Vivo Pharmacokinetics

In Vivo Immunogenicity Study An in vivo immunogenicity study evaluates a substance's ability to trigger an immune response within a living organism.
In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Show all 11 in In Vivo Pharmacokinetics 5 more

Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Medical Communications

Investigational Medicinal Product Dossier (IMPD) and Investigational New Drug (IND) Dossier Develop and submit Investigational Medicinal Product Dossier (IMPD) and Investigational New Drug (IND) Dossier
Regulatory Submissions and Compliance Draft, format, and submit documents to Pharmaceutical approval agencies according to documentation and guidelines. This includes documents such as NDAs, INDs, SUSARs, AE reporting, RMPs, and PSURS.
Toxicology Reports Create pre-clinical toxicology reports.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Non-Human Primate Models Use a single animal species to create one or more disease models.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Nanotechnology

Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.

Neurotoxicology

Single Dose Acute Neurotoxicity Study - Rat Conduct a single dose study in rats to determine the neurotoxicty of your compound.

Non-Human Biospecimen

Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Monkey / Non-Human Primate / NHP Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rat Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

CAR-T Efficacy In Vivo assessment of CAR-T and CAR-NK efficacy in a humanized mouse
Metastasis Tumor Model A metastasis tumor model is a preclinical system used to study the spread of cancer from a primary site to distant organs
NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.

Show all 10 in Oncology Models 4 more

Orthotopic Tumor Model Discover anti-tumor and anti-metastatic therapies for all tumor types.
Subcutaneous Tumor Model A subcutaneous (SC) tumor model is a widely used preclinical in vivo method where cultured cancer cells or tissue fragments are implanted beneath the skin of an animal, typically a mouse
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Xenografts Tumor Model A xenograft tumor model is an in vivo preclinical system in which human cancer cells or tissues are implanted into immunodeficient hosts, usually mice.

Other Specialty Toxicology

Cutaneous Phototoxicity Study - Mouse Conduct a study in mice to determine if a toxic response is elicited after the initial exposure to your compound and subsequent exposure to light.
Ocular Phototoxicty Study - Rat Conduct a study to determine the extent to which your compound is capable of producing phototoxic side effects in ocular tissues of rats.
Ototoxicity Study - Monkey / Non-human Primate Conduct a study in monkeys/non-human primates to determine the potential for your compound to cause hearing loss.

Protein Sciences

Adeno Associated Virus (AAV) Production Clone into AAV expression vectors and produce high titer viruses.
Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
FRET/BRET Detect the location of proteins in living cells and their ability to interact with other proteins.
Integrated Protein Production Package Process an entire Protein Production Pipeline Project including: Gene/Oligo Synthesis, Cloning/Subcloning, Protein Expression, Protein Purification, Protein Analysis, and Protein Products from our bundle of suppliers
Kinase Panel Assays Work with service providers offering biochemical assays to assess the activity of multiple protein kinases simultaneously to identify and characterize kinase inhibitors, understand selectivity trends, and assess...

Show all 23 in Protein Sciences 17 more

Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
mRNA Display Screen for proteins or peptides that bind a target.
Neoantigen Development Develop neoantigens for oncological therapeutics for vaccine development.
Peptide Derivatives Acquire chemicals that are peptide derivatives.
Peptide Discovery Identifying and developing new peptides.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
Protein Binding Determine drug-protein binding interactions
Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
Protein Products Find native and recombinant proteins and peptides.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Solution Phase Peptide Synthesis (SPS) Solution-phase peptide synthesis (SPS) is the classical, liquid-medium method for creating peptides by coupling amino acids
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.

REACH Services

Dossier Prep. and Consultancy Assistance with creation of a regulatory document that contains all the Clinical, non-clinical, and CMC information of a pharmaceutical product to be approved, registered, or marketed within a specific country.
In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests
OECD 402: Acute Dermal Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test chemical by dermal route.
OECD 403: Acute Inhalation Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation.
OECD 407: Repeated Dose 28-day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.

Show all 18 in REACH Services 12 more

OECD 412: Subacute Inhalation Toxicity: 28-Day Study This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data...
OECD 413: Subchronic Inhalation Toxicity: 90-day Study This revised Test Guideline 413 (TG 413) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a period of 90 days, and to provide data for quantitative...
OECD 416: Two-Generation Reproduction Toxicity This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive...
OECD 420: Acute Oral Toxicity - Fixed Dose Procedure A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use...
OECD 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.
OECD 423: Acute Oral toxicity - Acute Toxic Class Method The acute toxic class method set out in this Guideline is a stepwise procedure with the use of 3 animals of a single sex per step. Depending on the mortality and/or the moribund status of the animals, on average 2-4...
OECD 425: Acute Oral Toxicity: Up-and-Down Procedure The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling...
OECD 436: Acute Inhalation Toxicity – Acute Toxic Class Method The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according...
OECD 452: Chronic Toxicity Studies Evaluate the direct and indirect impact of prolonged and repeated toxin exposure to test organisms.
OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
Pyrogen Test Find suppliers who offer safety tests to detect fever-inducing substances (pyrogens) in pharmaceutical products, medical devices, and other biological products

Regulatory Affairs

Preparation Of Regulatory Dossiers Preparation of regulatory dossiers is the process of compiling detailed administrative, clinical, and scientific data into a standardized format
Regulatory Submission Documents Request services related to the submission and writing of New Drug Applications (NDA), Investigational New Drugs (INDs), and Investigator Brochures (IB) to the FDA and other regulatory bodies.

Regulatory Consulting

Toxicology Data Review Identify relevant toxicological endpoints for “No Observed (Adverse) Effect Level” (NO(A)EL) or “Lowest Observed (Adverse) Effect Level” (LO(A)EL).

Safety Pharmacology

CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Jacketed External Telemetry (JET) Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.

Scientific Data Services

T Cell Epitope Mapping Use peptide libraries make it possible to rapidly identify the epitopes of T-Cells, T-Cell clones, T-Helper Cell Clones, T-cell lines, and unpurified T-cells.

Specialty Dosing Routes

Chronic Intravenous Infusion Carcinogenicity Study - Rat Conduct a repeat intravenous infusion dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Intra-Auricular Toxicology Conduct a study to determine the toxicity and toxicokinetic behavior of your compound when delivered via the ear.
Intravitreal Toxicity and/or Toxicokinetic Study - Other Species Conduct an intravitreal ocular toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Lethal Dose (LD), 50% Toxicity Test Measure acute toxicity by identifying the amount of pure toxin required to kill half of the experimental subjects.
Repeat Dose Intranasal Study - Monkey / Non-human Primate Conduct a repeat dose intranasal study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Rat Conduct a repeat dose intranasal study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Show all 24 in Specialty Dosing Routes 18 more

Repeat Dose Intravenous Infusion Study - Dog / Canine Conduct a repeat dose intravenous infusion study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Monkey / Non-human Primate Conduct a repeat dose intravenous infusion study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Rats Conduct a repeat dose intravenous infusion study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Inhalation Study - Rat Conduct a single dose inhalation study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Dog / Canine Conduct a single dose intranasal study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Dog / Canine Conduct a single dose intravenous infusion study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Rats Conduct a single dose intravenous infusion study in rats to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Minipig Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to minipigs.
Topical Dermal Toxicity and/or Toxicokinetic Study - Monkeys/Non-human Primates Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to monkeys/non-human primates.
Topical Dermal Toxicity and/or Toxicokinetic Study - Mouse Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to mice.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rat Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rats.
Topical Ocular Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct a topical ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Mouse Conduct a topical ocular toxicity study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Non-pigmented (New Zealand White; NZW) Conduct a topical ocular toxicity study in non-pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rat Conduct a topical ocular toxicity study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
Elevated Temperature Stability Determine the stability of a product at elevated temperature.
OECD 439: Skin Irritation Test (SIT) Reconstructed Human Epidermis Test (RhE) Method - An in vitro testing method designed to identify chemicals and/or mixtures capable of inducing moderate skin irritation.
OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)

Website: www.biomedlinkage.com

China Meishan 1 site
Hong Kong Kowloon 1 site

Work with BioMed Linkage Tech Co., Limited on Scientist.com

For prices, more details, or to contact BioMed Linkage Tech Co., Limited, visit Scientist.com.

View on Scientist.com