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Research supplier
Virscio
Virscio is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 2 countries and 3 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
Biomarkers
- Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Clinical Trials
- Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.
Discovery Chemistry
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
Disease Models
- Arthritis Models Measure therapeutic endpoints in animal models of arthritis.
- Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
- Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
- Cataract Models Measure therapeutic endpoints in animal models of cataracts.
- Cognition Models Measure therapeutic endpoints in animal models of cognition.
Show all 17 in Disease Models
- Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
- Inflammation Model Consulting Measure therapeutic endpoints in animal models for inflammation.
- Macular Degeneration Models Use a single animal species to create one or more models for eye disease.
- Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
- Ocular Inflammation Models Measure ocular inflammation in models of eye disorders such as uveitis and keratitis.
- Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
- Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
- Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
- Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
- Stroke Models Measure therapeutic endpoints in animal models of stroke.
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
- Repeat Dose Toxicity Study - Monkey / Non-human Primate Conduct a repeat dose study in monkey/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Toxicity Study - Monkey / Non-human Primate Conduct a single dose study in Monkeys and Non-human Primates to determine the toxicokinetic behavior of your compound.
Show all 54 services
Human Biological Samples
- Tissue Acquisition Find primary animal and human tissues and cells.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Cell Fractionation Isolate organelles and subcellular components.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
In Vivo ADME
- Ocular Distribution Study - Monkey / Non-human Primate Conduct a study to determine the distribution of your compound in ocular tissues of the monkey/non-human primate.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Ocular Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
- Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Model Development
- Non-Human Primate Models Use a single animal species to create one or more disease models.
Non-Human Biospecimen
- Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
- Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
- Monkey / Non-Human Primate / NHP Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Other Specialty Toxicology
- Ototoxicity Study - Monkey / Non-human Primate Conduct a study in monkeys/non-human primates to determine the potential for your compound to cause hearing loss.
Safety Pharmacology
- CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
- Implanted Telemetry Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
- Safety Pharmacology Latin Square Study - Monkey / Non-human Primate Conduct a safety pharmacology study with a Latin square design in monkeys/non-human primates.
- Telemetry Use implantable or external devices to study physiological parameters in model organisms
Specialty Dosing Routes
- Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
- Intracameral Implant Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct an intracameral implant toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
- Intrathecal/Intraspinal Toxicology Conduct a study to determine the toxicity and toxicokinetic behavior of your compound when delivered via the intrathecal space.
- Intravitreal Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct an intravitreal ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
- Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.
- Repeat Dose Intranasal Study - Monkey / Non-human Primate Conduct a repeat dose intranasal study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Show all 10 in Specialty Dosing Routes
- Repeat Dose Intravenous Infusion Study - Monkey / Non-human Primate Conduct a repeat dose intravenous infusion study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.
- Topical Dermal Toxicity and/or Toxicokinetic Study - Monkeys/Non-human Primates Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to monkeys/non-human primates.
- Topical Ocular Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct a topical ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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KN 1 site
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
_*Bridging the Translational Gap Applying the Best Preclinical Models to Anticipate Clinical Outcomes*_ RxGen, a specialized preclinical CRO, is focused on advancing therapeutic development through the validation and application of clinically relevant disease models to define the optimal path to clinic. We offer extensive scientific and technical expertise in ophthalmology, central nervous system and metabolic disorders, and leverage decades of experience in the development and application of nonhuman primate research models and related preclinical services to advance translational...
Show the full description
_*Bridging the Translational Gap
Applying the Best Preclinical Models to Anticipate Clinical Outcomes*_
RxGen, a specialized preclinical CRO, is focused on advancing therapeutic development through the validation and application of clinically relevant disease models to define the optimal path to clinic. We offer extensive scientific and technical expertise in ophthalmology, central nervous system and metabolic disorders, and leverage decades of experience in the development and application of nonhuman primate research models and related preclinical services to advance translational programs.
_*The RxGen Advantage
Scientific Engagement. Clinically Relevant Models. Timely Execution.*_
RxGen has established a powerful preclinical platform, defined and designed to facilitate rapid and cost effective clinical translation, providing more relevant insight into the safety and efficacy of novel therapies, medical devices, and delivery technologies to accelerate and strengthen the preclinical decision making process. We place ultimate value on scientific excellence and innovation and the operational effectiveness with which our resources and models are applied toward achieving sponsor objectives. We have assembled the highest caliber scientific team, operating within a research environment designed to optimize data acquisition, animal well-being, and test system consistency to ensure clearest possible outcomes.
_*The RxGen Platform
Research Services that Truly Enable Clinical Translation*_
RxGen offers services specifically related to in vivo safety and efficacy evaluations, including, preclinical strategy, protocol design and development, in vivo study execution, data analysis, study reporting, and regulatory support. Our services have advanced programs ranging from large pharmaceutical companies to small preclinical biotechnology companies and academic teams seeking the most valuable translational models. All programs are pursued to the highest standards with full consideration of clinical objectives and animal welfare, and we are globally recognized for our efficient, cost effective study completion and the deep therapeutic domain expertise we bring to sponsor interactions.
Our models and capabilities include, but are not limited to:
Ophthalmology
- Wet age-related macular degeneration
- Laser-induced choroidal neovascularization
- Glaucoma
- IOP modulation
- Uveitis
- Immunogen induced uveitis
- Myopia
- Form-deprivation myopia
- Cataract
- Phacoemulsification surgical models
- Ocular Pharmacokinetics and Toxicology
- Topical, subretinal, punctal, subconjuntival, intravitreal, systemic
Central Nervous System (CNS)
- Parkinson's disease
- MPTP model
- Idiopathic Parkinson's disease
- L-dopa induced dyskinesias
- Schizophrenia
- PCP model of cognitive impairment
- Dystonia
- Neuroleptic sensitization
- Alzheimer's disease
- Abeta plaque formation in older cohorts
- Spinal cord injury
- Cord hemisection model
Metabolic
- Obesity
- Diet-induced obesity
- Naturally obese cohorts
- Dyslipidemia
- Diet-induced lipid profile modulation
- Selection of naturally variant phenotypes
- Diabetes
- Obesity associated insulin resistance
Women's Health
- Endometrial safety
- Endometrial tolerance of hormone therapies
- Osteoporosis
- Bone density in aged and/or ovariectomized females
Immunology
- Antigen challenge
- Adjuvant and vaccine evaluations
Surgical Models
- Surgical disease models
- Device implantation
Pharmacokinetics & Safety Assessments
- Professional associations
- BIOCOM, SOT
- Website
- www.virscio.com
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