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MRIGlobal
MRIGlobal is listed as a small business research supplier in the Scientist.com network, with 3 sites in 1 country and 5 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Chemical and Compound Analysis
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- Compound Integrity Analyze the identity and purity of small molecule drug candidates.
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
Show all 15 in Chemical and Compound Analysis
- Ion Exchange Chromatography Separate and detect analytes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
- Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Chemistry, Manufacturing and Controls (CMC)
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Clinical Consulting
- Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
- Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
- Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
- Product Testing Consulting Expert advice to evaluate the effectiveness, quality, and legitimacy of a given item or good.
Show all 78 services
Clinical Trials
- Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Discovery Chemistry
- Compound Purchase Consulting Buy compounds, building blocks or compound libraries.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Show all 8 in Discovery Chemistry
- Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
- UV and IR Profiling Analyze the integrity of a compound or large biomolecule.
Disease Models
- Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.
- Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
- Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
- Malaria Models Measure therapeutic endpoints in animal models of malaria.
- Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
Show all 9 in Disease Models
- Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
- Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
- Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
DNA & RNA
- DNA Library Screening Screen genomic or cDNA libraries for positive clones.
- RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
- Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.
- Structural Chemistry Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro Assays
- Antivirals Measure anti-viral activity in biochemical and cell assays.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
In Vivo ADME
- Bioequivalence Assess the expected in vivo biological equivalence of two proprietary preparations of a drug.
In Vivo Pharmacokinetics
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
- Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Other Specialty Toxicology
- Biosafety Testing Consulting Expert advice to conduct safe and responsible biological procedures and practices.
- Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
- United States Pharmacopeia (USP) Testing Use USP standards to ensure quality of pharmaceuticals, supplements and food ingredients.
- Viral Testing Characterize viral products for functional activity and possible contamination.
Product Orders
- BioTx General Biotherapeutics analyze therapeutics and drugs via biological means and recombinant DNA. Pre-clinical sample bioanalysis and le...
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Scientific Data Services
- Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Specialty Dosing Routes
- Dermal Toxicology Assess toxicity in rodent dermal testing models.
- Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Target Animal and Human Food Safety
- Target Animal Safety (TAS) Studies Evaluate potential harmful effects associated with the use of a new animal drug in a controlled setting.
- Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
- Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.
- Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Elevated Temperature Stability Determine the stability of a product at elevated temperature.
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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United States 3 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
MRIGlobal, a contract research and development organization, delivers solutions in global health, national security and defense, and energy and the environment. The organization performs scientific research, advanced engineering, integration, and program management for clients in government, industry, and academia. Established in 1944 as Midwest Research Institute, MRIGlobal is based in Kansas City, Mo., operates in nine locations. MRIGlobal employs more than 500 and manages 2,600-plus workers through management and operations programs with government clients. MRIGlobal’s Diagnostics...
Show the full description
MRIGlobal, a contract research and development organization, delivers solutions in global health, national security and defense, and energy and the environment. The organization performs scientific research, advanced engineering, integration, and program management for clients in government, industry, and academia.
Established in 1944 as Midwest Research Institute, MRIGlobal is based in Kansas City, Mo., operates in nine locations. MRIGlobal employs more than 500 and manages 2,600-plus workers through management and operations programs with government clients.
MRIGlobal’s Diagnostics Division provides assay development for menu expansion in in vitro and molecular diagnostics, validation and clinical testing, sample access and reference material, and platform engineering and integration.
MRIGlobal operates a Clinical Laboratory Improvement Amendments (CLIA)-laboratory accredited by the College of American Pathologists. MRIGlobal is ISO 9001 certified and employs current Good Manufacturing Practices and Good Laboratory Practices, and maintains Biosafety Level 3 laboratories.
www.mriglobalDX.com www.mriglobal.org
- Professional associations
- MOBIO
- Website
- www.mriglobal.org
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