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Quotient Sciences
Quotient Sciences is listed as a large business research supplier in the Scientist.com network, with 6 sites in 2 countries.
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Sites
6
Countries
2
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Chemical and Compound Analysis
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chemical Stability Measure the stability of small molecules in solution.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
- Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
Show all 21 in Chemical and Compound Analysis
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
- Impurities in API Risk assessment Create a risk-based control strategy to determine any impurities in Active Pharmaceutical Ingredients (API).
- Inductively Coupled Plasma (ICP) Analysis Characterize ultra-small levels of multiple solid analytes simultaneously.
- Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
- Process Residual Impurities Detection Measure trace levels of impurities.
- Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Chemistry, Manufacturing and Controls (CMC)
- API and Drug Product Stability Testing API and Drug Product Stability Testing.
- API and Drug Product Storage and Distribution API and Drug Product Storage and Distribution.
- API and drug product storage and release API and drug product storage and release
- API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
- API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
- API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
Show all 21 in Chemistry, Manufacturing and Controls (CMC)
- API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
- Bulk Manufacturing Find facilities for large-scale mass production.
- Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Drug Substance and Drug Product Characterization and Manufacturing Drug Substance and Drug Product Characterization and Manufacturing.
- Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.
- Fill and Finish Processing Confirm final product sterility, formulation and packaging in the biopharmaceutical process.
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Powder Blending Use automatic or semi-automatic powder blending machinery to produce consistent mixes.
- Powder Filling Use manual, automatic or semi-automatic machinery to package a variety of powder and granules.
- Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Show all 79 services
Discovery Chemistry
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
- Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
Show all 12 in Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
- Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
- Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
- Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
- UV and IR Profiling Analyze the integrity of a compound or large biomolecule.
Drug Development
- Chemistry, Manufacturing and Controls (CMC) Consulting Consultant services related to the development of pharmaceutical and biopharmaceutical drug products that are consistently effective, safe and high quality for consumers.
In Vitro ADME
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
- In Vitro ADME in Vitro ADME services
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Show all 16 in In Vitro ADME
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
- Reference Standards Find reference standards for assays, tests and services.
In Vitro Assays
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
In Vivo Pharmacokinetics
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Radioanalysis
- Stand-alone Radioanalysis of Animal Pre-clinical Samples Conduct analysis of radioactive samples from preclinical radiolabeled studies.
- Stand-alone Radioanalysis of Human Clinical Samples Conduct analysis of radioactive samples from clinical metabolism radiolabeled studies.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Elevated Temperature Stability Determine the stability of a product at elevated temperature.
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Where it operates
Sites by country, with the cities in each.
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United Kingdom 4 sites
-
United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
- Professional associations
- AAPS, BayBio, BioFlorida, BioNJ, DCAT, MassBio, NCBIO, PABio, SOT, SoCalBio, Texas BioAlliance, VirginiaBio, WBIA
- Website
- www.quotientsciences.com
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