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Research supplier
Adesis, Inc.
Adesis, Inc. is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 2 countries and 1 service area.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Agricultural Sciences Research & Development
- General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.
- Molecular Markers Use of molecular diagnostics to analyze biological markers in the genome and proteome.
- Synthetic Fertilizers Determination of heavy metals and other toxic compounds in addition to composition.
Chemical and Compound Analysis
- Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
- Chemical Stability Measure the stability of small molecules in solution.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- Compound Integrity Analyze the identity and purity of small molecule drug candidates.
- Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
- Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Show all 18 in Chemical and Compound Analysis
- Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
- Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
- Ion Exchange Chromatography Separate and detect analytes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
- Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
- Photostability Measure drug degradation rates after exposure to various light sources.
- Process Residual Impurities Detection Measure trace levels of impurities.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Chemistry, Manufacturing and Controls (CMC)
- Advanced intermediates Sourcing advanced intermediates
- Analytical Development and Validation Request services related to Analytical Development and Validation
- API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
- API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
- API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
- Bulk Manufacturing Find facilities for large-scale mass production.
Show all 16 in Chemistry, Manufacturing and Controls (CMC)
- Crystallization studies Crystallization studies
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Drug Substance and Drug Product Characterization and Manufacturing Drug Substance and Drug Product Characterization and Manufacturing.
- Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
- ICH-compliant stability testing Perform ICH-compliant stability testing
- Phosphates Acquire phosphates to use as ingredients in consumer healthcare products.
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Regulatory Starting Materials Sourcing regulatory starting materials (RSM)
- Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Show all 60 services
Discovery Chemistry
- Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
- Compound Purchase Buy compounds, building blocks or compound libraries.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Show all 12 in Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
- Pharmaceutical Research Chemicals Acquire chemicals that are prospective new drug entities.
- Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
- Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
DNA & RNA
- Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
- Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
In Vitro ADME
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Protein Sciences
- Peptide Derivatives Acquire chemicals that are peptide derivatives.
- Peptide Discovery Identifying and developing new peptides.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
- X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Service areas:
Where it operates
Sites by country, with the cities in each.
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Ireland 1 site
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Adesis is a contract research organization (CRO) that provides custom synthesis services specializing in advanced intermediates, reference compounds, resolution of enantiomers, chiral synthesis, natural products semi-synthesis and stable isotope labeled compounds. We specialize in the synthesis of milligrams to kilogram quantities including: Early stage proof-of-concept (POP) projects to validate biological hypotheses Validation of screening hits for exploratory medicinal chemistry (hit-to-lead) In-depth structure-activity relationship (SAR) studies Intermediates for expediting med...
Show the full description
Adesis is a contract research organization (CRO) that provides custom synthesis services specializing in advanced intermediates, reference compounds, resolution of enantiomers, chiral synthesis, natural products semi-synthesis and stable isotope labeled compounds.
We specialize in the synthesis of milligrams to kilogram quantities including:
- Early stage proof-of-concept (POP) projects to validate biological hypotheses
- Validation of screening hits for exploratory medicinal chemistry (hit-to-lead)
- In-depth structure-activity relationship (SAR) studies
- Intermediates for expediting med chemistry SAR campaigns
- Drug candidates for in vivo studies
- Reference agents for bioprofiling
- Reference metabolites
- Building blocks for combinatorial chemistry
- Key intermediates for pharmaceuticals
- Key intermediates for biomaterial and biosensor applications
Outsourcing should be a strategic component of any sponsor's research and development portfolio, instead of an ad hoc decision. It is a decision which factors in 1) cost-risk benefits (internal vs. external), 2) timing, 3) potential CRO's skillset capabilities and business practices. In medicinal chemistry, this strategy allows in-house chemists to focus on the design and assembly of new lead molecules vs. routine syntheses which can be outsourced. Virtual biopharmaceutical companies have embraced outsourcing in order to direct maximum start-up funds to reaching proof-of-concept instead of immediate creation of infra-structure.
- Professional associations
- ACS, DCAT, DelawareBio, MassBio, PABio
- Website
- www.adesisinc.com
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