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Lonza
Lonza is listed as a mid sized business research supplier in the Scientist.com network, with 36 sites in 15 countries and 4 service areas.
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Sites
36
Countries
15
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Antibody Conjugation Conjugate an enzyme, biotin, or fluorophore to an antibody.
- Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
- Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
- Antigen Specific T-cells T cell lines that recognize specific peptide antigens to enable analysis of T cell immunity.
- In Silico Humanization Predict epitope binding specificity, increase in vivo half-life and allow rapid modeling and humanization of antibodies.
Biomarkers
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Show all 9 in Biomarkers
- Osteoclasts Measure osteoclast activity and bone resorption in human, mouse or rat assays.
- Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
- T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
Show all 160 services
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Line Authentication Verify the identity and purity of an experimental cell line or industrial culture.
- Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Show all 16 in Cell Culture and Characterization
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- cGMP Cell Banking Request information or a price quote for cGMP Cell Banking services
- Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
- Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
- Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
- Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
- Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
- Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Chemical and Compound Testing
- Nutritional Testing Analyze food safety, vendor specifications, foreign substance identification processes and nutritional labeling.
- Product Testing Ensure product quality standards are met.
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Clinical Consulting
- Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
- Regulatory Consulting Ensure that each product or device complies with all FDA rules and regulations.
Data Science/Bioinformatics
- In Silico Protein Modification Analysis Use computational methods to predict the behavior of modified proteins.
Discovery Chemistry
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
- Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Disease Models
- Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
- Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
- Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
DNA & RNA
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- DNA Library Screening Screen genomic or cDNA libraries for positive clones.
- DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
- Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
- Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
- RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
Show all 7 in DNA & RNA
- RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Human Biological Samples
- Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
- Cell Line and Cellular Services Promotion for Cells and Cell lines
- FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
- HBS Asthma For requesting HBS Asthma.
- HBS Chronic Obstructive Pulmonary Disease (COPD) Acquire fresh, frozen, or fixed COPD tissue or for requesting other COPD human biospecimen samples.
- HBS Diabetes For requesting HBS Diabetes.
Show all 36 in Human Biological Samples
- HBS Healthy/Controls For requesting HBS Healthy/Controls
- HBS NASH For requesting HBS NASH
- HBS Oncology For requesting Human biospecimens from Oncology indications
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- HBS: Human Biological Samples - BI STEP 1: EDIT the title above to reflect the human biospecimens you would like to order. STEP 2: If you already know the supplier you wish to use, please include them in the request form. If you have not identified...
- HBS: Human Biological Samples - VMS Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- Human Adult Stem Cells Acquire human stem cells isolated from various adult tissues.
- Human Blood Acquire fresh/frozen human blood based on patient demographics, disease stage, history and treatment.
- Human Blood by-products For requesting Human Blood By-products
- Human Bone Marrow Aspirates Acquire fresh/frozen Bone Marrow mononuclear cells based on patient demographics, disease stage, treatment and history.
- Human Bone Marrow Cells Acquire fresh, frozen, or fixed normal bone marrow based on patient demographics and history.
- Human Buffy Coats Acquire fresh/frozen Buffy Coats based on patient demographics, disease stage, treatment and history.
- Human Cell Lysates For requesting human Cell lysates.
- Human Fresh Tissue For requesting fresh human tissue
- Human Hepatocytes Acquire human hepatocytes isolated from the liver.
- Human HSC's For requesting human sourced hematopoetic stem cells
- Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
- Human iPSC's For requesting human sourced induced pluripotent stem cells.
- Human Leukopaks Obtain enriched leukapheresis-derived products from normal peripheral blood.
- Human MSC's For requesting human sourced mesenchymal stem cells.
- Human Neural Stem Cells Acquire human neural stem cells isolated from brain tissue.
- Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
- Human Plasma Acquire fresh/frozen human plasma
- Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
- Human Red Blood Cells Acquire fresh/frozen normal red blood cells based on patient demographics and history.
- Human Serum Acquire fresh/frozen normal serum based on patient demographics and history.
- Human Umbilical Cord Blood For requesting Human Umbilical Cord Blood.
- Human Uterus For requesting Human Uterus Samples
- Human Whole Blood For requesting Human Whole Blood
- SARS-CoV-2 (COVID-19) Human Biological Samples Search for available SARS-CoV-2 human biological samples
In Vitro ADME
- Cell Fractionation Isolate organelles and subcellular components.
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- ELISpot Assay and Testing Detect low levels of antigens.
Show all 10 in In Vitro Assays
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Lipolysis Measure the hydrolysis of triglycerides into glycerol and free fatty acids.
- Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
- In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Show all 9 in In Vitro Pharmacology
- Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
- Protease Assay Measure protease activity in biochemical and cell-based assays.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cytotoxicity Test for effects on cell viability and proliferation
- Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
- Epidermal Cell Toxicity Measure toxicity by quantifying the number of live/dead cells, cell membrane integrity and glutathione (GSH) levels.
- Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
Show all 9 in In Vitro Toxicology
- HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
- Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.
Lab Supplies, Facilities, and Equipment
- Biobanking Store and track biological samples.
Model Development
- PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
Non-Human Biospecimen
- Dog / Canine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
- Guinea Pig Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
- Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
- Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
- Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
- Pig / Minipig / Porcine Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Show all 7 in Non-Human Biospecimen
- Rat Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Other Specialty Toxicology
- Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
- United States Pharmacopeia (USP) Testing Use USP standards to ensure quality of pharmaceuticals, supplements and food ingredients.
Pharmacovigilance
- GxP Compliance Monitoring Ensure products or services adhere to a set minimum standard.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Protein Binding Determine drug-protein binding interactions
- Protein Engineering Alter the features or properties of a protein for a specific purpose.
- Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Show all 7 in Protein Sciences
- Protein Purification Isolate native or recombinant proteins from a sample.
Raw Materials
- Adjusters Adjust the pH of a finished product with Spectrum's wide selection of cosmetic pH adjusters. These chemical ingredients maintain the stability of formulations and efficacy of the finished cosmetic or personal care...
- Fillers Ingredient used to create bulk, texture or lubrication
Safety Pharmacology
- Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Scientific Data Services
- Software Tools Software tool for statistical analysis, data mining, genome annotation or NGS data analysis.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
- Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
- PAO Stability Trial Assess the stability of a consumer product under certain storage conditions.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Show all 7 in Testing Services
- Safety In-Use Studies Safety-in-use studies assess the potential for a product to elicit adverse reactions under normal use conditions.
Other services
- Biological Material For requesting cells and other propagatable material.
- Human Dendritic Cell (hDC) Model Test and validate the immune-modulating compounds in DC immune pathway models.
- New Request
Service areas:
Biology
Chemistry
Manufacturing
Clinical
Where it operates
Sites by country, with the cities in each.
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United States 11 sites
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China 4 sites
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Netherlands 3 sites
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Switzerland 3 sites
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United Kingdom 3 sites
Showing 5 of 15 countries.
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Lonza offers custom manufacturing services based on biotechnologies including mammalian cell culture, stem cells, and microbial fermentation, in addition to peptide synthesis, advanced chemical synthesis and cell therapy services.
- Website
- www.Bioscience.Lonza.com
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