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Latvian Institute of Organic Synthesis (LIOS)
Latvian Institute of Organic Synthesis (LIOS) is listed as an academic core research supplier in the Scientist.com network, with 2 sites in 1 country.
View Latvian Institute of Organic Synthesis (LIOS) on Scientist.com
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Academic core
Biomarkers
- Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Chemical and Compound Analysis
- Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
- Chemical Stability Measure the stability of small molecules in solution.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Structural Chemistry Examine the relationship between protein structure and function.
Chemistry, Manufacturing and Controls (CMC)
- Analytical Development and Validation Request services related to Analytical Development and Validation
- API and Drug Product Stability Testing API and Drug Product Stability Testing.
- API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
Discovery Chemistry
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Show all 9 in Discovery Chemistry
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
- Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
- Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Show all 23 services
In Vitro ADME
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacology
- In Vivo Pharmacology Study the effects of drug candidates in animal models
Protein Sciences
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Safety Pharmacology
- Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.
- Website
- www.niri.lv/en
Where it operates
Sites by country, with the cities in each.
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Latvia 2 sites
Work with Latvian Institute of Organic Synthesis (LIOS) on Scientist.com
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