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Corning Life Sciences
Corning Life Sciences is listed as a large business research supplier in the Scientist.com network, with 3 sites in 1 country and 1 service area.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Human Biological Samples
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
In Vitro ADME
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Show all 12 in In Vitro ADME
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Multidrug Resistance Identify potential causes of drug-drug interactions.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
In Vitro Pharmacology
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
- Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
- Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
In Vitro Toxicology
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
Protein Sciences
- Protein Binding Determine drug-protein binding interactions
Show all 20 services
Other services
- Corning® Gentest™ Tissue Fractions Corning® Gentest™ Tissue Fractions
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
-
United States 3 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
https://www.corning.com/worldwide/en/products/life-sciences/products/adme-tox-research.html
Corning Life Sciences offers a variety of in vitro ADME Gentest® branded products and contract research services covering drug metabolism and drug interactions. These products and services support Enzyme Induction, Enzyme Inhibition, Metabolic Stability, Reaction Phenotyping, Protein Binding, Permeability and Drug Transport and other applications.
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