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Sia Analiz Laboratuvarları

Sia Analiz Laboratuvarları is listed as a mid sized business research supplier in the Scientist.com network, with 1 site in 1 country.

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Type of company: Mid sized business

Agricultural Sciences Compliance and Quality Control Measures

OECD 213: Honey Bee Acute Oral Toxicity Test Expose adult bees to a test chemical by feeding over 2 days for short-term toxicity assessment.
OECD 214: Honey Bee Acute Contact Toxicity Test Expose adult bees to a test chemical by topical application over 2 days for short-term toxicity assessment.

Antibodies

Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.

Developmental and Reproductive Toxicology (DART)

Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Drug Development

Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

General in vivo Toxicology

Avian Toxicology Investigation Use toxicity tests to predict avian exposure risk, assess exposure effects or confirm product safety for registration.
Carcinogenicity Study - Mouse Conduct a repeat dose, chronic carcinogenicity study in mice to determine the tendency of your compound to produce tumors.
Carcinogenicity Study - Rat Conduct a repeat dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.

Show all 13 in General in vivo Toxicology 7 more

Effective Dose (ED), 50% Toxicity Test Quantify the diluted toxin needed to induce sub-lethal effects upon constant exposure in half of test organisms.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.

In Vitro ADME

HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...

Show all 79 services 67 more

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Cell Proliferation Measure cell number, cell viability and cell division.

In Vitro Toxicology

Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity

Medical Communications

Toxicology Reports Create pre-clinical toxicology reports.

Model Development

Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.

Neurotoxicology

Single Dose Acute Neurotoxicity Study - Rat Conduct a single dose study in rats to determine the neurotoxicty of your compound.

Other Specialty Toxicology

Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).
Static Acute Toxicity Test Measure toxicity endpoints in aquatic organisms exposed to a non-renewed test solution for the entire experiment.
Viral Testing Characterize viral products for functional activity and possible contamination.

REACH Services

Hazard, Exposure and Risk Assessment Evaluate the known hazard of a test compound in conjunction with the expected quantity and frequency of exposure.
In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests
In Vitro Skin Sensitization Determine whether a drug or cosmetic product may cause dermal sensitization.
In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 223: Avian Acute Oral Toxicity Test This Test guideline describes procedures designed to estimate the acute oral toxicity of substances to birds.
OECD 402: Acute Dermal Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test chemical by dermal route.

Show all 29 in REACH Services 23 more

OECD 403: Acute Inhalation Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation.
OECD 404: Acute Dermal Irritation/Corrosion This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application.
OECD 405: Acute Eye Irritation/Corrosion This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye.
OECD 406: Skin Sensitisation This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application.
OECD 407: Repeated Dose 28-day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 410: Repeated Dose Dermal Toxicity: 21/28-day Study This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance.
OECD 411: Subchronic Dermal Toxicity: 90-day Study This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance.
OECD 412: Subacute Inhalation Toxicity: 28-Day Study This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data...
OECD 420: Acute Oral Toxicity - Fixed Dose Procedure A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use...
OECD 421: Reproduction/Developmental Toxicity Screening Test The test substance is administered in graduated doses to several groups of males and females.
OECD 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.
OECD 423: Acute Oral toxicity - Acute Toxic Class Method The acute toxic class method set out in this Guideline is a stepwise procedure with the use of 3 animals of a single sex per step. Depending on the mortality and/or the moribund status of the animals, on average 2-4...
OECD 425: Acute Oral Toxicity: Up-and-Down Procedure The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling...
OECD 431: In Vitro Skin Corrosion: Human Skin Model Test The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight...
OECD 436: Acute Inhalation Toxicity – Acute Toxic Class Method The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according...
OECD 451: Carcinogenicity Studies The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test...
OECD 452: Chronic Toxicity Studies Evaluate the direct and indirect impact of prolonged and repeated toxin exposure to test organisms.
OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
Pyrogen Test Find suppliers who offer safety tests to detect fever-inducing substances (pyrogens) in pharmaceutical products, medical devices, and other biological products

Regulatory Consulting

Environmental Fate and Ecotoxicology Data Review Identify relevant endpoints for fate and behavior (metabolism and excretion, degradation and soil adsorption) and toxicity (soil organisms, aquatic organisms, and dung fauna) of animal health products.
Toxicology Data Review Identify relevant toxicological endpoints for “No Observed (Adverse) Effect Level” (NO(A)EL) or “Lowest Observed (Adverse) Effect Level” (LO(A)EL).

Specialty Dosing Routes

Chronic Intranasal Carcinogenicity Study - Rats Conduct a repeat dose intranasal, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Intrathecal/Intraspinal Toxicology Conduct a study to determine the toxicity and toxicokinetic behavior of your compound when delivered via the intrathecal space.
Lethal Dose (LD), 50% Toxicity Test Measure acute toxicity by identifying the amount of pure toxin required to kill half of the experimental subjects.
Repeat Dose Inhalation Study - Rat Conduct a repeat dose inhalation study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Show all 12 in Specialty Dosing Routes 6 more

Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Rat Conduct a repeat dose intranasal study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Inhalation Study - Rat Conduct a single dose inhalation study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Mouse Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to mice.

Target Animal and Human Food Safety

Honey Bee Chronic Feeding Test Evaluate the toxic effects of an agrochemical after 10 days of feeding exposure in adult honey bees.

Testing Services

In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
OECD 439: Skin Irritation Test (SIT) Reconstructed Human Epidermis Test (RhE) Method - An in vitro testing method designed to identify chemicals and/or mixtures capable of inducing moderate skin irritation.

Website: www.siatoxicology.com

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