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Axxam

Axxam is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country and 1 service area.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 2

Countries 1

Type of company: Mid sized business

Agricultural Sciences Compliance and Quality Control Measures

Pesticide Product Testing Use laboratory assays to evaluate the efficacy, safety and selectivity of a pesticide under GLP standards.

Bioimaging

In Vivo Whole Tissue and Animal Imaging Visualize, analyze and track light producing reporters in whole animals.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.

Biomarkers

Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.

Cell Culture and Characterization

Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
Insect Tissue Culture Grow insect cells.

Show all 9 in Cell Culture and Characterization 3 more

Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.

Chemical and Compound Analysis

NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.

Show all 113 services 99 more

Chemistry, Manufacturing and Controls (CMC)

Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Data Science/Bioinformatics

Discovery Data Analysis Analysis that helps you make sense of your discovery data
Discovery Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data for its users.
Discovery Databases Databases specifically designed for drug discovery use.

Discovery Chemistry

Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.

Show all 12 in Discovery Chemistry 6 more

LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.

DNA & RNA

Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.

Show all 7 in DNA & RNA 1 more

Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.

In Vitro ADME

Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.

Show all 14 in In Vitro Assays 8 more

Cell Proliferation Measure cell number, cell viability and cell division.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Serine Protease Assay Detect apoptosis by measuring protease activity.

In Vitro Pharmacology

Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.

Show all 33 in In Vitro Pharmacology 27 more

High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
Target Identification Identify the target(s) of a biologically active substance.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.

In Vitro Toxicology

Cardiac Channels Measure the arrhythmia producing potential of test compounds.
Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.

Protein Sciences

Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.

Show all 16 in Protein Sciences 10 more

Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Phosphorylation Analysis Identify phosphorylation sites in target proteins.
Protein Binding Determine drug-protein binding interactions
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Purification Isolate native or recombinant proteins from a sample.
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.

Other services

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Service areas:

Biology

Italy Bresso, Torre Annunziata 2 sites

Axxam S.p.A. is a privately owned contract research and discovery company located at Openzone Science Park, Bresso (Milan, Italy), with chemistry laboratories located in Naples (Italy) and business development offices in US and Japan. Since its inception in 2001, as a spin-off from the Bayer Group, Axxam has supported the discovery programs of its clients by providing excellent quality services carried out by highly engaged experts. Our passion for conducting client’s discovery programs is complemented by the pharmaceutical industry experience from both, the management as well as...

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Since its inception in 2001, as a spin-off from the Bayer Group, Axxam has supported the discovery programs of its clients by providing excellent quality services carried out by highly engaged experts. Our passion for conducting client’s discovery programs is complemented by the pharmaceutical industry experience from both, the management as well as the scientist teams.

Our capabilities and expertise include:

Molecular biology (cloning, gene expression analysis, protein expression, genomic engineering)
Assay development and reagent provision (cellular and biochemical systems)
Compound management
Fully automated High-Throughput Screening (various read-outs including also radiometric formats)
Fully automated High Content Screening and imaging
Hit characterization & profiling
Access to the AXXDIV2.0 compound collection (around 240,000 compounds)
Cardiac safety and liability profiling
Electrophysiology

These capabilities paired with our discovery mentality have allowed us to successfully execute:

Hit identification projects
Hit-to-lead projects
Lead optimization programs

We are guided by a truly collaborative mentality, based on transparent processes and open communication. We are providing resources, expertise in a broad range of target classes, know-how, but also a problem-solving attitude and passion for our work. Each customer is equally important to us and this has been recognized by more than 70% of our business being based on repeated contracts. Axxam’s customer base is distributed around the globe and represents companies active in Pharmaceutical, Crop protection, Animal health, Cosmetics, Nutrition.

Website: www.axxam.com

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