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A&M Labor fur Analytik und Metabolismusforschung Service GmbH
A&M Labor fur Analytik und Metabolismusforschung Service GmbH is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 2 service areas.
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
- Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Biomarkers
- Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
- Autoantibody Testing Screen for the presence of an autoimmune disorder.
- Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Show all 11 in Biomarkers
- Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Insulin Autoantibodies (IAA) Testing Detect the risk or presence of type 1 diabetes in early childhood.
- Lipid Profiling Use quantitative analysis of blood lipid components to assess cardiac risk.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Chemical and Compound Analysis
- Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
- API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
- Chemical Stability Measure the stability of small molecules in solution.
- Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
- Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
- Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Show all 22 in Chemical and Compound Analysis
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
- High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
- Ion Exchange Chromatography Separate and detect analytes.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
- Photostability Measure drug degradation rates after exposure to various light sources.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
- Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
- Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Show all 97 services
Chemistry, Manufacturing and Controls (CMC)
- API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
- API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.
- Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
Clinical Trials
- Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Discovery Chemistry
- Extractable and Leachable Assessment Quantify potential impurities from container closures & packaging.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Effectiveness
- Bioequivalence Studies for Veterinary Drugs Assess the expected biological equivalence of two proprietary preparations of a veterinary drug.
General in vivo Toxicology
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro ADME
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
Show all 24 in In Vitro ADME
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
- Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
- Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
- Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
- Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
- Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
- Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
- Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Show all 8 in In Vivo Pharmacokinetics
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Protein Sciences
- Carbohydrate Structure Characterization Use analytical tools to elucidate carbohydrate structure and physiochemical properties.
- N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
- Protein Identification Uncover or confirm the identity of a protein.
- Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Target Animal and Human Food Safety
- Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.
Testing Services
- Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
- Elevated Temperature Stability Determine the stability of a product at elevated temperature.
- Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
- Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
- Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.
Other services
- New Request
Service areas:
Chemistry
DMPK
Where it operates
Sites by country, with the cities in each.
-
Germany 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
A&M is focused in offering their expertise in pharmaceutical analysis, mass spectrometry, metabolite identification, and bioanalysis services.
Work with A&M Labor fur Analytik und Metabolismusforschung Service GmbH on Scientist.com
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