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Concept Life Sciences

Concept Life Sciences is listed as a mid sized business research supplier in the Scientist.com network, with 5 sites in 1 country and 2 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 5

Countries 1

Type of company: Mid sized business

Agricultural Sciences Compliance and Quality Control Measures

Endocrine Screening Screening to determine risk due to disruption of the endocrine system.
Pesticide Product Testing Use laboratory assays to evaluate the efficacy, safety and selectivity of a pesticide under GLP standards.

Agricultural Sciences Research & Development

Agrochemical Analytical Method Development Engineer sensitive and selective methods that meet GLP validation requirements to assess different agrochemical properties.
Agrochemical Identification Product identification and composition of pesticides; which includes fungicides, insecticide, herbicides and nematicides analysis.
Bacteriology PCR and MS-Based Bacterial Identification
Chemical and Physical Determination of chemical and physical properties of pesticide product.
General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.
Method Development & Validation Engineer sensitive and selective methods that meet GLP validation requirements to access different agrochemical properties

Show all 9 in Agricultural Sciences Research & Development 3 more

Molecular Markers Use of molecular diagnostics to analyze biological markers in the genome and proteome.
Soil Science Test for microbial inoculants that promote plant health
Synthetic Fertilizers Determination of heavy metals and other toxic compounds in addition to composition.

Anatomic Pathology

Immunohistochemistry Services Prepare, stain and label with histological and immunological reagents, then evaluate slide preparation of cells or tissue.

Antibodies

Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody-Dependent Cell-Mediated Cytotoxicity Request services related to cell-mediated immune defense.
Immunodetection Use antibodies to identify a protein or antigen.

Show all 428 services 416 more

Bioimaging

Confocal/Optical Microscopy Use optical imaging technique to increase optical resolution and contrast of a micrograph.
Cryo Electron Microscopy Examine the 3D structure of biological complexes and organelles.
Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Microscopy Use microscopy to analyze surfaces of biological materials and to develop 3D images of biological structures.

Biomarkers

Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Membrane Lipidomics Study the pathways and networks of membrane lipids.
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.

Show all 37 in Biomarkers 31 more

Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Peptide Bioanalysis Analyze the structure of Peptides.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Protein Bioanalysis Quantitative measurement of xenobiotics (drugs and their metabolites, and biological molecules in unnatural locations or concentrations) and Proteins in biological systems
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
T Cell Epitope Characterization Evaluate the potency and immunodominance of T-cell epitopes within a molecule.
TUNEL Assay Detect in situ DNA fragmentation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

Show all 21 in Cell Culture and Characterization 15 more

Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
H & E Services For requesting services related to H&E Services
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Insect Tissue Culture Grow insect cells.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Resin-based Histology Perform sectioning and histological analysis of epoxy/acrylic/polycarbonate-embedded samples.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Yeast Cell Culture Grow yeast strains or species.

Chemical and Compound Analysis

Amino Acid Analysis (AAA) Determine protein quantities, relative compositions and amino acid content profiles.
Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Compound Integrity Analyze the identity and purity of small molecule drug candidates.

Show all 49 in Chemical and Compound Analysis 43 more

Denaturing High Performance Liquid Chromatography Separate mixtures of denatured and reannealed oligos to identify single nucleotide substitutions, deletions and insertions.
Differential Scanning Calorimetry Elucidate the thermodynamics associated with conformational transitions.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
Endotoxin Testing Use standard assays like LAL (Limulus Amebocyte Lysate), rFC (Recombinant Factor C), or MAT (Monocyte Activation Test) to detect and quantify the level of endotoxins in a sample
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Headspace Gas Chromatography Analyze volatile organic compounds (VOCs) partitioned above the liquid/solid phase of a sample.
Heavy Metals Analysis Ensure trace levels of heavy metals are below the maximum allowable limits for consumer safety.
High Resolution MS Elucidate the sequence and structure of peptides, proteins, biomarkers and organic compounds.
Immunoaffinity Chromatography Use antibody-antigen interactions to isolate and concentrate analytes.
Inductively Coupled Plasma (ICP) Analysis Characterize ultra-small levels of multiple solid analytes simultaneously.
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Analysis Detect metals and several non-metals at concentrations as low as one part in 1015 (part per quadrillion, ppq) on non-interfered low-background isotopes.
Ion Exchange Chromatography Separate and detect analytes.
Isothermal Titration Calorimetry An ITC assay will be established and optimised for the affinity measurement of test substance to target molecule.
Lipid Nanoparticle (LNP) Characterization Lipid nanoparticle (LNP) characterization is the process of comprehensively analyzing the physical and chemical properties of LNPs and their components to understand their structure, quality, and functionality
Liquid Chromatography Separate substances using a mobile and stationary phase.
MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
Photostability Measure drug degradation rates after exposure to various light sources.
Phototoxicity & Photosensitization Test Test the potential for a product to elicit a reaction under UV exposure.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Protein Structure Determine the three dimensional structure of a protein by NMR or x-ray crystallography.
Raman Spectroscopy Use spectroscopic technique to observe vibrational, rotational and other low-frequency modes in a system.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Scanning and Transmission Electron Microscopy Examine the fine structures of molecules, cells and tissues with sub-nanometer resolution.
Secondary Ion Mass Spectrometry Detect trace level impurities and obtain elemental or molecular chemical data for solid sample surfaces.
Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Spray Drying Convert a liquid into a powder by rapidly drying the mixture and removing the moisture component.
Static Light Scattering Use scattered light intensity to determine the average molecular weight of biopolymers.
Structural Chemistry Examine the relationship between protein structure and function.

Chemical and Compound Testing

Nutritional Testing Analyze food safety, vendor specifications, foreign substance identification processes and nutritional labeling.
Product Testing Ensure product quality standards are met.
USP <2022> Microbiological Procedures for Absence of Specified Microorganisms Determine the absence of objectionable organisms in nutritional supplements.

Chemistry, Manufacturing and Controls (CMC)

Advanced intermediates Sourcing advanced intermediates
Analytical Development and Validation Request services related to Analytical Development and Validation
API and drug product storage and release API and drug product storage and release
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
API Stress Testing Studies Develop analytical methods to predict stability problems and identify degradation products/pathways under forced degradation conditions.
API/ Excipients Compatibility Studies Delineate real and possible interactions between potential formulation excipients and the API as an important risk reduction exercise early in formulation development.

Show all 24 in Chemistry, Manufacturing and Controls (CMC) 18 more

API/DP specific test methods API/DP specific test methods (e.g., stability indicating HPLC assay and purity)
Bulk Raw Materials Acquire raw materials in large volumes at wholesale pricing.
Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Compendial test methods Run Compendial test methods (e.g., KF)
Crystallization studies Crystallization studies
Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
Drug Repurposing Discovering new therapeutic uses for existing drugs that are outside the scope of the original medical indication.
Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
ICH-compliant stability testing Perform ICH-compliant stability testing
Milling, grinding, spray-drying Milling, grinding, spray-drying
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Regulatory Starting Materials Sourcing regulatory starting materials (RSM)
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Thermo Scientific iCAP Q ICP-MS Expand your analytical capabilities with this complete trace elemental analysis solution for your high-throughput lab.

Clinical Consulting

Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...

Clinical Trials

Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Data Science/Bioinformatics

Discovery Bioinformatics Different analytical approaches that make, store, and analyze complex biological data.
Discovery Biomarker Analytics An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Translational Bioinformatics Different analytical approaches that make, store, and analyze complex biological data.
Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.

Discovery Chemistry

Bioanalytical Lab Services Bioanalytical Lab Services
Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Certified Standards Find certified standards for assays, tests and services.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.

Show all 31 in Discovery Chemistry 25 more

Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Leachable and extractable testing Leachable and extractable testing
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
Pharmaceutical Research Chemicals Acquire chemicals that are prospective new drug entities.
Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Target-Focused Compound Libraries Find activity-based libraries directed towards a protein or cell signaling target.
Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
USP Testing Analytical Reagents Acquire chemical reagents, solution concentrates and volumetric solutions used to evaluate items in USP testing.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.

Show all 13 in Disease Models 7 more

Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.

DNA & RNA

Capillary Electrophoresis Separate ng quantities of DNA to single base resolution.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Extraction Extract DNA from an original source.
DNA Sequencing Determine the nucleotide sequence of DNA samples.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.

Show all 23 in DNA & RNA 17 more

NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
RNAscope In Situ Assays Profile single-cell gene expression in situ.
Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
Spatial Transcriptomics Determine the sub-cellular localization of mRNA molecules. Use this to identify cellular heterogeneity in tissues, tumors, immune cells and the subcellular distribution of transcripts.
TCR Repertoire Sequencing Analyze the T cell receptor repertoire by means of next-generation sequencing.
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.
Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
Whole Genome Sequencing Determine the entire genetic make-up of an organism.

Drug Development

Bioinformatics Consulting Consulting Services for the science of collecting and analyzing complex biological data
Cellular Immunology Consulting Immunological activities of cells in experimental or clinical situations
Chemistry, Manufacturing and Controls (CMC) Consulting Consultant services related to the development of pharmaceutical and biopharmaceutical drug products that are consistently effective, safe and high quality for consumers.
Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.

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Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Effectiveness

In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.

Farm & Livestock Solutions

Animal Feed Analysis Test the content and quality of nutrients and biologically active substances in animal feeds. Some analysis that is conducted on feed include; dry matter, crude ash, ash insoluble in acid (sand), crude protein, crude...
Food Pathogen Testing of Listeria, salmonella, campylab, 0157E coli.
Viral Molecular Diagnostic Determination of genetic markers for virus identification. Detect common infectious agents and foreign animal diseases that may threaten animal or human health.
Virology Virus isolation for identification of new and emerging viruses.

General in vivo Toxicology

General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.

Human Biological Samples

Human iPSC's For requesting human sourced induced pluripotent stem cells.
Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.

Show all 34 in In Vitro ADME 28 more

CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Apoptotic Cell Staining Detect apoptotic cells in culture.
Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

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Cell Proliferation Measure cell number, cell viability and cell division.
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
ELISpot Assay and Testing Detect low levels of antigens.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Invasion Assays Monitor and quantify the ability of cultured cells to permeate real or artificial biological barriers.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
Tube Formation Assay Monitor the in vitro formation of three dimensional 3D tube structures.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
ATP Competitive Study Determine whether or not a compound is competitive with ATP.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Cellular Thermal Shift Assay Use a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.

Show all 56 in In Vitro Pharmacology 50 more

Dehydrogenase Assays Measure dehydrogenase activity in biochemical and cell-based assays.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
Histone Acetyltransferase (HAT) Assays Use biochemical, cell-based or in vivo assays to measure histone acetyltransferase activity.
Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.
Human BCL Assays Use biochemical, cell-based or in vivo assays to measure BCL activity.
Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Nucleoside Transporter Assays Use biochemical, cell-based or in vivo assays to measure nucleoside transporter activity.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
PARP Assays Use biochemical, cell-based or in vivo assays to measure PARP activity.
Peptide Transporter Assays Use biochemical, cell-based or in vivo assays to measure peptide transporter activity.
Peroxidase Assays Measure peroxidase activity in bacterial and mammalian cells.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Programmed Death-Ligand 2 (PD-L2) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of PD-L2 ligand.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Protein/Enzyme Targets For requesting Protein/Enzyme Targets
Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
Solute-Linked Carrier (SLC) Transporter Inhibition Assays Use biochemical, cell-based or in vivo assays to measure solute-linked carrier transporter activity.
Solute-Linked Carrier (SLC) Transporter Substrate Identification Use biochemical, cell-based or in vivo assays to identify solute-linked carrier transporter substrates.
Target Characterization Characterize potential drug targets during the drug discovery process.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
Ubiquitin Ligase Assays Measure ligase enzyme activity in the presence of cofactors or chemical modifiers.
UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cytotoxicity Test for effects on cell viability and proliferation
Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
HepaRG Cells Obtain terminally differentiated and cryopreserved hepatic cells that retain many characteristics of primary human hepatocytes.

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Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Microelectrode Array Cardiotoxicity Assays Use microelectrode array to measure cardiotoxicity-related activities.

In Vivo ADME

Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.

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Pharmacokinetic (PK) Screening - Monkey / Non-human Primate Conduct a pharmacokinetic screening study in monkeys/non-human primates that measures the absorption, distribution, metabolism and excretion of your compound.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.

Management Optimization & Development Strategies

OECD Regulatory Development Consultation in safety testing, chemical notification and registry within OECD.

Model Development

Custom Model Development Develop a custom disease model.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.

Oncology Models

Nervous System PDX Patient derived xenografts relating to the components of the Nervous System. This includes PDX from the Brain, Spinal Cord, and Nerves.

Other Specialty Toxicology

Biosafety Testing In Vitro Test biologics, raw materials, lot release and viral safety
Raw Materials Testing Verify that raw materials are sterile and not contaminated by mycoplasma, virus or other microorganisms.
United States Pharmacopeia (USP) Testing Use USP standards to ensure quality of pharmaceuticals, supplements and food ingredients.

Protein Sciences

Analytical Ultracentrifugation Characterize the interactions and properties of macromolecules in solution.
Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...

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Immunoprecipitation Precipitate a protein of interest out of solution using an antibody to which it binds.
Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
Peptide Derivatives Acquire chemicals that are peptide derivatives.
Peptide Discovery Identifying and developing new peptides.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Protein Binding Determine drug-protein binding interactions
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Quantitative MS Quantify small and large molecules in the pg/ml range
Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.

REACH Services

In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests
In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
OECD 407: Repeated Dose 28-day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.
OECD 452: Chronic Toxicity Studies Evaluate the direct and indirect impact of prolonged and repeated toxin exposure to test organisms.

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OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Safety Pharmacology

Endocrine Disruptor Screening Use biochemical, cell based or in vivo assays to identify and quantify endocrine-modulating agents.
Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
Neurotoxicity Study Study of the adverse effects of a substance on the brain or peripheral nervous system.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Genome Data Analysis Analyze genomic DNA, RNA and protein sequence data.
T Cell Epitope Mapping Use peptide libraries make it possible to rapidly identify the epitopes of T-Cells, T-Cell clones, T-Helper Cell Clones, T-cell lines, and unpurified T-cells.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Elevated Temperature Stability Determine the stability of a product at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.

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PAO Stability Trial Assess the stability of a consumer product under certain storage conditions.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Other services

In Vitro Neurodegenerative Disease Platform Use an IVND platform to screen different compounds/drugs in a finely controlled synaptopathies scenario.
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Chemistry DMPK

United Kingdom Dundee, Edinburgh, High Peak, Sandwich 5 sites

p<>. Peakdale Molecular is a leading UK-based CRO delivering a vast array of high quality services for early phase discovery with passion and skill. Our customers are drawn from pharma and biotech companies worldwide. p<>. Using its heritage in the supply of rational building blocks for medicinal chemistry, biased screening libraries and custom synthesis as a springboard, Peakdale now operates a comprehensive suite of services for hit-to-lead and lead optimisation studies encompassing computational and medicinal chemistry design, in vitro ADMET studies and, when appropriate PR&D studies...

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p<>. Peakdale Molecular is a leading UK-based CRO delivering a vast array of high quality services for early phase discovery with passion and skill. Our customers are drawn from pharma and biotech companies worldwide.

p<>. Using its heritage in the supply of rational building blocks for medicinal chemistry, biased screening libraries and custom synthesis as a springboard, Peakdale now operates a comprehensive suite of services for hit-to-lead and lead optimisation studies encompassing computational and medicinal chemistry design, in vitro ADMET studies and, when appropriate PR&D studies for scale-up. Above all, the most vital resource we offer is the collective skill of Peakdale workforce. With over 85% PhD-level scientists, they relish the challenge of problem-solving within client projects, offering scientific initiative, high levels of communication and utter confidentiality. The Peakdale combination of high productivity, critical thinking and innovation translates into exceptional value-for-money for our clients.

p<>. Based at two UK locations, Chapel-en-le-Frith (near Manchester) and Sandwich, we have assembled an enviable array of assets for small molecule discovery. Peakdale has all the essential hardware for modern organic chemistry, a purpose-built ADMET lab. with cell culture facilities, scale-up laboratories with vessels up to 50 L, high throughput automated purification to support array synthesis, a highly engineered suite for pressure chemistry (reaction screening and scale synthesis).

p<>. We boast particular expertise in tough Natural Product Chemistry, including Opiates, Nucleosides and Nucleotides. We are also gaining recognition for applying our skills to diverse problems such as the synthesis of Organic Electronic Materials.

p<>. Peakdale offers a variety of customised commercial frameworks, from simple fee-for-service right through to long-term FTE projects. We are trusted by major pharma & biotech companies and at one extreme, we operate an embedded team of Peakdale FTE scientists inside the client’s facility on a long-term basis.

Professional associations: BIOCOM, DCAT, MassBio
Website: www.conceptlifesciences.com

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