Prosilico

Prosilico is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.

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Sites 1

Countries 1

Type of company: Small business

Clinical Trials

Pharmacokinetic Studies Design a study that observes the time course of drug absorption, distribution, metabolism, and excretion, as means to test the safety and effective therapeutic management of drugs in an individual patient.

Data Science/Bioinformatics

In Silico ADME-PK Consultation Consult with experts for ADME-PK data analysis or predictive modelling design in different in vivo or in vitro states.
In Silico ADME-PK Predictions Use computer software to simulate in vivo physiological conditions of animals or humans to predict ADME-PK properties.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
In Silico Pro-drug Predictions Use computer simulation to assess pro-drug absorption and conversion to predict pharmacokinetic properties.

Discovery Chemistry

In Silico Metabolite Predictions Conduct in silico assessment of metabolite pharmacokinetic properties and potential exposure effects.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.

In Vivo Pharmacokinetics

Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.

Sweden 1 site

PROSILICO was founded in July 2014 by ex-AstraZeneca pharmacokineticist, PhD and associate professor in biopharmaceutics/pharmacokinetics Urban Fagerholm. He has a wide preclinical and clinical experience from more than 20 years in the pharmaceutical industry (AstraZeneca 1997-2013) and academia (Uppsala University), and has focused on prediction methodology, physiological models, mechanisms, analyses and strategies in the ADME/PK-field. In 2009, he was nominated International Educator of the Year and named member of Top 100 Professionals of the Year. He has published 36 scientific papers...

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In 2009, he was nominated International Educator of the Year and named member of Top 100 Professionals of the Year.
He has published 36 scientific papers and book chapters (see Resent Publications) and a popular science book (www.forutfattadmedicin.se).

During the years as preclinical and clinical pharmacokineticist at AstraZeneca he represented the ADME/PK-function in cross-functional project teams with overall responsibility for design, analyses and delivery of ADME/PK- and TK-studies, and ADME/PK-input to regulatory summary documents and at meetings with authorities. He played a key role in global and local teams responsible for predictive science (BBB/CNS, ADME/PK, PK/PD & in-silico ADME/PK). He also evaluated, improved and developed several ADME/PK prediction methods and platforms (PCS and PK-MATRIX), and initiated and lead a global postdoc project.

Urban is a reviewer of research manuscripts for Drug Metabolism and Disposition, Journal of Pharmacy and Pharmacology, European Journal of Pharmaceutical Sciences, Journal of Pharmaceutical Sciences, Molecular Pharmaceutics, Toxicology in Vitro, Expert Opinion on Drug Metabolism, Toxicology and Pharmaceutical Research, Current Drug Metabolism and Xenobiotica.

Website: prosilico.com

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