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Discovery Life Sciences - Services
Discovery Life Sciences - Services is listed as a large business research supplier in the Scientist.com network, with 5 sites in 2 countries.
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Sites
5
Countries
2
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Antibodies
- Hybridoma Sequencing/Antibody Sequencing Determine the sequences of monoclonal antibodies.
Bioimaging
- Bioimaging Visualize biological process non-invasively in real time.
Biomarkers
- Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
- Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.
- Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Show all 24 in Biomarkers
- Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Digital Pathology Acquire, manage and interpret pathology information generated from a digital image of a slide preparation of cells or tissue.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
- Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
- Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
- Multi-Omics Study Use an integrated multi-omics study to understand a disease mechanism.
- Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
- Proteocarta™ HCP Detect Services Identify and track host cell proteins (HCP) with mass spectrometry for higher sensitivity and coverage.
- Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
- Single Cell Transcriptome Sequencing Detect distinct, rare or abnomal cell types in a heterogenous population.
- Spatial Metabolomics The study of the spatial distribution and localization of metabolites within biological tissues using advanced imaging and analytical techniques.
- Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Biometrics
- Specialty/Niche Labs Find providers covering a broad range of services that go beyond routine testing and analyses to support clinical trials.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
- Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
Show all 15 in Cell Culture and Characterization
- Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
- H & E Services For requesting services related to H&E Services
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
- In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
- Microsatellite Instability Analysis Compare allelic profiles and detect genomic instability.
- Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
- Single Cell DNA Sequencing Examine genetic variations in a single cell.
- Single Cell Services Request services to perform genomics, transcriptomics, proteomics, metabolomics and cell–cell interactions at the single cell level
Show all 117 services
Chemical and Compound Analysis
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Data Science/Bioinformatics
- Proteome Data Analysis Find tools for analysis of homology and similarity, protein function and structural properties.
Discovery Chemistry
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
Disease Models
- Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
DNA & RNA
- Bisulfite Seq DNA Methylation Analysis Determine DNA methylation status at single-base resolution
- Chromatin Analysis Analyze DNA-Histone interactions and modifications
- DNA Extraction Extract DNA from an original source.
- DNA Sequencing Determine the nucleotide sequence of DNA samples.
- Exome Sequencing Determine protein-coding nucleotide sequences in a DNA sample.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
Show all 22 in DNA & RNA
- Integrated Genomics Package Process an entire Genomics Pipeline Project including: Sample Preparation, Target Enrichment, NGS Instrumentation, and Data Analysis from our Bundle of Suppliers
- Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
- miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
- NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
- RAD Sequencing Examine a small percentage of the target genome.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
- RNA Sequencing Use Next Generation Sequencing techniques to Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- RNA Sequencing/Resequencing Identify RNA transcripts, examine differential expression patterns and analyze splice variants.
- RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
- RNAseq and DNAseq library preparation and sequencing DNA/RNA sequencing and preparations
- Sequence Based Methylation Analysis Detect DNA methylation sites within cytosine-phosphate-guanine (CpG) dinucleotides at single base-pair resolution.
- Single Cell RNA Sequencing Quantify mRNA variants in a single cell.
- Spatial Transcriptomics Determine the sub-cellular localization of mRNA molecules. Use this to identify cellular heterogeneity in tissues, tumors, immune cells and the subcellular distribution of transcripts.
- Targeted Sequencing/Resequencing Detect variations in a genome subset.
- Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
- Whole Genome Sequencing Determine the entire genetic make-up of an organism.
Human Biological Samples
- HBS Alzheimer's Acquire fresh, frozen, or fixed Alzheimer's tissues or other related Alzheimer's HBS.
- Liquid Biopsy Test and detect either circulating tumor cell-associated biomarkers or circulating tumor DNA.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
Show all 13 in In Vitro ADME
- In Vitro ADME in Vitro ADME services
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
- Monoamine Transporter Assays Measure monoamine neurotransmitter uptake in cultured cells.
Show all 8 in In Vitro Assays
- Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
- Reactive Species Assays Use biochemical, cell-based or in vivo assays to detect and evaluate the effects of reactive species.
In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
- Time Dependent Study Determine whether or not a compound binds to an enzyme in a time-dependent manner.
- Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
- Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
- Tubule Epithelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the kidney.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Model Development
- Fresh Functional Human Tissue Efficacy Assays Use fresh functional human tissue to assess pre-clinical efficacy of test compounds.
- Fresh Functional Human Tissue Safety Assays Use fresh functional human tissue to assess pre-clinical safety of test compounds.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
- Integrated Proteomics Package Process an entire Proteomics Pipeline Project including: Sample Preparation, Target Enrichment, NGS Instrumentation, and Data Analysis from our Bundle of Suppliers
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Mass Spectrometry-Based Proteomics Detect histone post-translational modifications (hPTMs), histone variants, and interactomes at chromatin regions.
- Protein Identification Uncover or confirm the identity of a protein.
Show all 9 in Protein Sciences
- Protein Sequencing Determine the amino acid sequence of protein or peptide.
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
- Quantitative MS Quantify small and large molecules in the pg/ml range
Other services
- Integrated Human Biospecimen Package Utilize a Human Biospecimen Pipeline Package to process or characterize Human Biological Samples including: Sample Preparation, Histochemistry, Hybridization, Sequencing, Cell Based Assays, and Sample Bioanalysis from...
- Website
- dls.com
Where it operates
Sites by country, with the cities in each.
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United States 4 sites
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Germany 1 site
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