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PhysioStim
PhysioStim is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country and 1 service area.
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Bioimaging
- In Vivo Whole Tissue and Animal Imaging Analysis Analysis of images from in vivo studies produced using PET, MRI, CT, etc. in a variety of species.
Biomarkers
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
Cell Culture and Characterization
- Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
- Stem Cell Methodologies Study Stem Cell characteristics.
Chemical and Compound Analysis
- Ultrasound Tomography Use the transmission and acquisition of ultrasound waves to create a non-invasive technique for imaging.
Developmental and Reproductive Toxicology (DART)
- Bioelectronics Evaluate an application (e.g. device) that integrates biological materials and micro and nano-electronics.
Discovery Chemistry
- Certified Standards Find certified standards for assays, tests and services.
Disease Models
- Artery On-A-Chip Platform Assess small blood vessels under near-in vivo conditions.
- Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
- Electrophysiology Models Measure voltage change on a variety of scales from single ion channels to whole organs.
- In Vivo Physiologic Monitoring Monitor and collect data from conscious, freely moving laboratory animals.
- In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Show all 11 in Disease Models
- Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
- SHR/NCrl Rat Use a single animal species to create one or more disease models fior hematopoesis.
- Stroke Models Measure therapeutic endpoints in animal models of stroke.
- Thrombosis Models Measure therapeutic endpoints in animal models of thrombosis.
- Ventricular Tachycardia Models Measure therapeutic endpoints in animal models of ventricular tachycardia.
Show all 79 services
Drug Development
- Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
- Pharmacology Consulting Request consulting services related to pharmacology and the chemical properties, biological effects, and therapeutic uses of drugs.
- Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.
- Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
- Toxicology Consulting Use models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Human Biological Samples
- HBS Cardiovascular Disease Request tissue samples and Bio-specimen samples from patients with Cardiovascular Disease
- Human Biopsy Cell Models Request human biopsy cell models.
- Human Fresh Tissue For requesting fresh human tissue
In Vitro ADME
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
In Vitro Assays
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Fully Automated Assays Develop and perform assays that require no manual steps
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Pharmacology
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Nitric Oxide Synthase Assays Measure nitric oxide synthase activity by biochemical or cellular assays.
Show all 8 in In Vitro Pharmacology
- Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
- Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
In Vitro Toxicology
- Cardiac Channels Measure the arrhythmia producing potential of test compounds.
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
- Cardiovascular Toxicology Measure the toxic effects of pre-clinical compounds.
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
Show all 10 in In Vitro Toxicology
- Endothelial Cell Toxicity Assess the cytotoxic effects of pre-clinical compounds on the vascular system.
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
- Microelectrode Array Cardiotoxicity Assays Use microelectrode array to measure cardiotoxicity-related activities.
- Perfused Heart Examine cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects.
In Vivo Pharmacokinetics
- In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
- Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Medical Communications
- Toxicology Reports Create pre-clinical toxicology reports.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
- Custom Model Development Develop a custom disease model.
- Fresh Functional Human Tissue Contractile Force Assays Use fresh functional human tissue to assess contractile force with various compounds.
- Fresh Functional Human Tissue Efficacy Assays Use fresh functional human tissue to assess pre-clinical efficacy of test compounds.
- Fresh Functional Human Tissue Ion Channel Activity Assays Use fresh functional human tissue to assess ion channel activity with various compounds.
- Fresh Functional Human Tissue Safety Assays Use fresh functional human tissue to assess pre-clinical safety of test compounds.
Show all 11 in Model Development
- Fresh Functional Human Tissue Vasoconstriction Assays Use fresh functional human tissue to assess vasoconstriction with various compounds.
- Fresh Functional Human Tissue Vasodilation Assays Use fresh functional human tissue to assess vasodilation with various compounds.
- Pulmonary Hypertension Animal Model Study the pathology of pulmonary arterial hypertension (PAH) and investigate potential therapies.
- Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
- Zucker Rat Use a single animal species to create one or more disease models for cachexia.
Pharmacology
- In Vivo Pharmacology Study the effects of drug candidates in animal models
REACH Services
- Ex Vivo REACH Assays Perform testing on cells or tissues cultured directly from a test organism
- In Vivo REACH Services Performing testing when in vitro studies cannot be used to predict biological responses
Safety Pharmacology
- Implanted Telemetry Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
- Implanted Telemetry Study - Monkey / Non-human Primate Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in monkeys/non-human primates.
- Implanted Telemetry Study - Other Species Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in other species.
- Implanted Telemetry Study - Rat Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in rats.
- Jacketed External Telemetry (JET) Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
- Jacketed External Telemetry (JET) Study - Minipig Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in minipigs.
Show all 10 in Safety Pharmacology
- Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
- Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.
- Telemetry Use implantable or external devices to study physiological parameters in model organisms
Other services
- New Request
Service areas:
Toxicology
Where it operates
Sites by country, with the cities in each.
-
France 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
PhysioStim is a French GLP CRO, with 13 years of know-how in cardiac cellular electrophysiology. PhysioStim will help you to support your projects on preclinical cardiac safety pharmacology studies. In addition to GLP studies necessary for the regulatory dossiers, PhysioStim offers other “follow up” studies, important, essential to have a global vision of the cardiac effects of assay compounds. Our models are based on: -ionic channels assays (hERG, hNaV1.5, hKVLQT1, hCaV1.2, hKV4.3 essays) -action potential recordings (Purkinje fibers, atria, guinea pig papillary muscles...
Show the full description
PhysioStim is a French GLP CRO, with 13 years of know-how in cardiac cellular electrophysiology.
PhysioStim will help you to support your projects on preclinical cardiac safety pharmacology studies.
In addition to GLP studies necessary for the regulatory dossiers, PhysioStim offers other “follow up” studies, important, essential to have a global vision of the cardiac effects of assay compounds.
Our models are based on:
-ionic channels assays (hERG, hNaV1.5, hKVLQT1, hCaV1.2, hKV4.3 essays)
-action potential recordings (Purkinje fibers, atria, guinea pig papillary muscles, excitation-contraction coupling…)
-isolated cardiomyocytes (isolated from iPS cells)
-isolated langendorff perfused heart (ECG recording and hemodynamics parameters, myocardial accumulation of compounds)
-compounds interaction (addictive effect of 2 drugs on cardiac function).
- Website
- www.physiostim.com
Work with PhysioStim on Scientist.com
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