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SAI Life Sciences

SAI Life Sciences is listed as a large business research supplier in the Scientist.com network, with 4 sites in 3 countries and 4 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 4

Countries 3

Type of company: Large business

Antibodies

In Silico Humanization Predict epitope binding specificity, increase in vivo half-life and allow rapid modeling and humanization of antibodies.

Biomarkers

Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.

Show all 16 in Biomarkers 10 more

Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Cell Culture and Characterization

Cell Culture Culture primary or immortalized cell lines.

Chemical and Compound Analysis

API Physical Characteristics Characterize physical and chemical properties of new drug molecules to develop safe, effective, and stable dosage forms.
Chemical Stability Measure the stability of small molecules in solution.
Chiral Separation Purify therapeutically active isomers of drug candidates.
Dissolution Profiling Measure release of API from formulation (tablet or capsules) under GMP guidelines.
Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.

Show all 20 in Chemical and Compound Analysis 14 more

GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Liquid Chromatography Separate substances using a mobile and stationary phase.
Melting Point Use melting point analysis to characterize compounds based on calorimetry and thermodynamic data.
Natural Product Libraries Find microbial, botanical and marine sources of natural products.
NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
Photostability Measure drug degradation rates after exposure to various light sources.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
Structural Chemistry Examine the relationship between protein structure and function.
UV-Spectroscopy Conduct sample analysis based on light absorption and transmission.

Show all 176 services 162 more

Chemical and Compound Testing

Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.

Chemistry, Manufacturing and Controls (CMC)

Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Forced Degradation Run light, heat, humidity, acid hydrolysis and oxidation tests to evaluate substance degradation.
GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.

Show all 7 in Chemistry, Manufacturing and Controls (CMC) 1 more

Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.

Discovery Chemistry

Activity Prediction Identify possible chemical hits based on the known three-dimensional structure of a protein.
Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Certified Standards Find certified standards for assays, tests and services.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.

Show all 22 in Discovery Chemistry 16 more

Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Radiochemical Synthesis Radiolabel small molecules, peptides, cytotoxics or antibody drug conjugates for DMPK analysis.
Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

General Pain Models Measure therapeutic endpoints in animal models of general pain.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
Lupus Models Measure therapeutic endpoints in animal models of lupus.

Show all 12 in Disease Models 6 more

Neuropathic Pain Models Measure therapeutic endpoints in animal models of neuropathic pain.
Osteoarthritic Pain Models Measure therapeutic endpoints in animal models of osteoarthritic pain.
Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Pain Models Test therapeutic efficacy of drug candidate in pain model.
Systemic Lupus Erythematosus Models Measure therapeutic endpoints in animal models of immune disorders such as SLE and lupus.
Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.

DNA & RNA

Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.

Drug Development

Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.

General in vivo Toxicology

Dose Range Finding Study - Dog /Canine Conduct a study to determine the dose range of your compound in dogs/canines.
Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).

Show all 29 in In Vitro ADME 23 more

CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
No Label Methods Use mass spectrometry to detect and identify non-radiolabeled drug intermediates in pre-clinical samples.
Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Radiolabeled Tracers Use radiolabeled drug metabolites as radiotracers for measuring desired physiological processes.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
BrdU S-Phase Analysis Assess cell division or apoptosis by measuring thymidine-analog label incorporation during DNA replication.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Proliferation Measure cell number, cell viability and cell division.

Show all 15 in In Vitro Assays 9 more

Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
HTS Assay Development Develop assays to use in high throughput screening.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
Phenotype Assays Measure effects of drug candidate on the morphology or function of cells and whole animals.
PrimeFlow™ RNA Assay Reveal the unique kinetics of mRNA and protein in the same cell and identify expression differences as they change over time in response to stimulus.

In Vitro Pharmacology

G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
Protease Assay Measure protease activity in biochemical and cell-based assays.
Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.

Show all 12 in In Vivo Pharmacokinetics 6 more

Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Model Development

In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.

Oncology Models

Ex-Vivo PDX Screening Ex-vivo PDX screening is used to evaluate the effectiveness of various drugs on tumor cells.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Pharmacology

In Vivo Pharmacology Study the effects of drug candidates in animal models

Product Orders

Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Fluorescence Polarization Investigate receptor-ligand interactions, protein-DNA interactions, proteolysis and membrane fluidity.
Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
Protein Binding Determine drug-protein binding interactions
Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.

Show all 8 in Protein Sciences 2 more

Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

REACH Services

OECD 406: Skin Sensitisation This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application.
OECD 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.

Testing Services

Accelerated Stability Determine shelf life of drug formulations by comparing API breakdown at elevated temperature.
Freeze-Thaw Testing Use freeze-thaw cycling to measure the long-term durability of cosumer products.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Package Compatibility Tests Ensure that the consumer product is not adversely affected by the package components and vice versa.
Real-time Stability Test Assure stability and physical integrity of consumer products in real-time conditions.

Other services

New Request

Service areas:

Chemistry DMPK Pharmacology Toxicology

India Hyderabad 2 sites
United Kingdom Alderley Park 1 site
United States Watertown 1 site

Established in 1999, SAI has focused on building expert core capabilities in chemistry: synthetic chemistry, medicinal chemistry, process development, scale-up chemistry, analytical and manufacturing, and has effectively expanded to provide high-quality integrated services in DMPK, toxicology and formulation development to better support the increasing needs of our customers. The company`s world-class management team is composed of highly experienced executives and the distinguished members of the SAB are actively involved in helping to attain our high standards of science and execution...

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For business inquires, please contact:

Yu Chen, Director of Business Development (Tel: [removed]; Eamil: [removed])

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Professional associations: MassBio
Website: www.sailife.com

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