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Scantox A/S

Scantox A/S is listed as a mid sized business research supplier in the Scientist.com network, with 6 sites in 4 countries and 3 service areas.

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Sites 6

Countries 4

Type of company: Mid sized business

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.

Cell Culture and Characterization

Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Neurosphere Generation Neurosphere generation is a laboratory technique for culturing and studying neural stem cells by growing them in suspension to form free-floating clusters (neurospheres).

Chemical and Compound Analysis

GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Sample Bioanalysis Determination of concentration of an analyte in biological sample.

Chemical and Compound Testing

Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.

Show all 141 services 129 more

Chemistry, Manufacturing and Controls (CMC)

Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers

Developmental and Reproductive Toxicology (DART)

Embryo-Fetal Development (EFD) Study (Segment II) Test drug candidate in Segment II toxicology services.
Embryo-Fetal Development (EFD) Study (Segment II) - Other Species Conduct a study to determine the effect of compound exposure on the pregnant animal and the developing fetus.
Fertility and Embryonic Development Study (Segment I) - Other Species Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in other species.
Fertility and Embryonic Development Study (Segment I) - Rat Conduct a study to determine the effect of your compound on the estrous cycle, spermatogenesis/male reproductive organs, fertility of parents, and development of the embryo in rats.
Juvenile Toxicity Study - Dog / Canine Conduct a study to determine the differences in toxicity between immature and mature systems in dogs.
Juvenile Toxicity Study - Other Species Conduct a study to determine the differences in toxicity between immature and mature systems in other species.

Show all 7 in Developmental and Reproductive Toxicology (DART) 1 more

Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.

Disease Models

Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.

Show all 13 in Disease Models 7 more

LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
Morris Water Maze Investigate spatial learning and memory in rodents.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

DNA & RNA

DuplexSeq™ Mutagenesis Assay DuplexSeq™ Mutagenesis Assays use error-corrected next-generation sequencing to directly quantify ultra-rare mutations with unprecedented accuracy. The technology can be used across regulatory genetic toxicology...
NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Targeted Sequencing/Resequencing Detect variations in a genome subset.

General in vivo Toxicology

Dose Range Finding Study - Dog /Canine Conduct a study to determine the dose range of your compound in dogs/canines.
Dose Range Finding Study - Mouse Conduct a study to determine the dose range of your compound in mice.
Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.

Show all 16 in General in vivo Toxicology 10 more

Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Dog / Canine Conduct a repeat dose study in dogs to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Mouse Conduct a repeat dose study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Other Species Conduct a repeat dose study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Short-Term Toxicity Tests Acquire preliminary data about the concentrations, exposure duration and effects of a toxin on organisms.
Single Dose Acute Toxicity Study - Dog / Canine Conduct a single dose study in Dogs and Canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Toxicity Study - Mouse Conduct a single dose study in Mice and Murines to determine the toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

In Vitro Assays

Assay Development Construct or create new assays or modify existing ones.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
ELISpot Assay and Testing Detect low levels of antigens.
SARS-CoV-2 (COVID-19) Assays Search for Available SARS-CoV-2 Assays

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations

In Vivo Pharmacokinetics

Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rabbit Conduct a pharmacokinetic screening study in rabbits that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.

Show all 8 in In Vivo Pharmacokinetics 2 more

Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.

Model Development

Custom Model Development Develop a custom disease model.
Juvenile Toxicology Assess developmental and reproductive defects due to neurobehavioral, skeletal and muscle growth effects.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Oncology Models

Oncology Xenografts Xenografts derived from oncological samples.

Other Specialty Toxicology

Phototoxicity Determine whether drug treatment causes light-activated toxic effects.

Protein Sciences

ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.

REACH Services

OECD 405: Acute Eye Irritation/Corrosion This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye.
OECD 406: Skin Sensitisation This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application.
OECD 407: Repeated Dose 28-day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents This method provides information on health hazard likely to arise from exposure to test substance via oral administration.
OECD 410: Repeated Dose Dermal Toxicity: 21/28-day Study This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance.
OECD 411: Subchronic Dermal Toxicity: 90-day Study This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance.

Show all 17 in REACH Services 11 more

OECD 431: In Vitro Skin Corrosion: Human Skin Model Test The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight...
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 437: Bovine Corneal Opacity and Permeability Test Method (BCOP) for Identifying Ocular Corrosives and Severe Irritants The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to classify substances as 'ocular corrosives and severe irritants'.
OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
OECD 475: Mammalian Bone Marrow Chromosomal Aberration Test The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese...
OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.
REACH Services Assist in the registration, evaluation and authorization of chemical substances.

Safety Pharmacology

CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Implanted Telemetry Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Jacketed External Telemetry (JET) Study - Dog / Canine Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in dogs/canines.
Jacketed External Telemetry (JET) Study - Minipig Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in minipigs.
Jacketed External Telemetry (JET) Study - Other Species Conduct a study that allows the continuous collection of cardiovascular data following dosing of your compound in other species.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.

Show all 9 in Safety Pharmacology 3 more

Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Safety Pharmacology Study with Functional Observational Batteries (FOBs) - Other Species Conduct a safety pharmacology study with functional oberservational batteries in other species.
Telemetry Use implantable or external devices to study physiological parameters in model organisms

Scientific Data Services

NGS: Next Generation Sequencing Data Analysis Use software to interpret data created by RNA-Seq, DNA-Seq, ChIP-Seq and DNA methylation experiments.

Specialty Dosing Routes

Dermal Toxicology Assess toxicity in rodent dermal testing models.
Intravitreal Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct an intravitreal ocular toxicity study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Minipig Conduct an intravitreal ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Other Species Conduct an intravitreal ocular toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Rabbit, Pigmented (Dutch Belted, New Zealand Red) Conduct an intravitreal ocular toxicity study in pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.

Show all 28 in Specialty Dosing Routes 22 more

Repeat Dose Intranasal Study - Dog / Canine Conduct a repeat dose intranasal study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Other Species Conduct a repeat dose intranasal study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Dog / Canine Conduct a repeat dose intravenous infusion study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Other Species Conduct a repeat dose intravenous infusion study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Dog / Canine Conduct a single dose intranasal study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Other Species Conduct a single dose intranasal study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Dog / Canine Conduct a single dose intravenous infusion study in dogs/canines to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Other Species Conduct a single dose intravenous infusion study in other species to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to dogs/canines.
Topical Dermal Toxicity and/or Toxicokinetic Study - Minipig Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to minipigs.
Topical Dermal Toxicity and/or Toxicokinetic Study - Mouse Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to mice.
Topical Dermal Toxicity and/or Toxicokinetic Study - Other Species Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to other species.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rabbit Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rabbits.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rat Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rats.
Topical Ocular Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct a topical ocular toxicity study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Minipig Conduct a topical ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct a topical ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Mouse Conduct a topical ocular toxicity study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Non-pigmented (New Zealand White; NZW) Conduct a topical ocular toxicity study in non-pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Pigmented (Dutch Belted, New Zealand Red) Conduct a topical ocular toxicity study in pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rat Conduct a topical ocular toxicity study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Testing Services

Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
OECD 439: Skin Irritation Test (SIT) Reconstructed Human Epidermis Test (RhE) Method - An in vitro testing method designed to identify chemicals and/or mixtures capable of inducing moderate skin irritation.
OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.
OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.
OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)

Other services

Biological Material For requesting cells and other propagatable material.
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Service areas:

Biology DMPK Toxicology

Denmark Ballerup, Lille Skensved 2 sites
Sweden Lund, Mölndal 2 sites
Austria Grambach 1 site
United Kingdom Alderley Edge 1 site

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Website: www.scantox.com

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