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IIT Research Institute
IIT Research Institute is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country and 5 service areas.
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Antibody Detection Quantitate, localize and visualize proteins and other antigens.
- Immunodetection Use antibodies to identify a protein or antigen.
Biomarkers
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Focus Forming Assay Use colorimetric or immunofluorescence-based readouts to quantify virions prior to any plaque formation.
- Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Show all 12 in Biomarkers
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
- Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
- Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Cell Culture and Characterization
- Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
- Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.
Chemical and Compound Analysis
- Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
- Compound Integrity Analyze the identity and purity of small molecule drug candidates.
- GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
- NBE RIB 2/5 BA Request information or a price quote for GLP Large Molecule Bioanalysis services and products
Show all 9 in Chemical and Compound Analysis
- Non GLP Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of large biomolecules.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Show all 98 services
Chemical and Compound Testing
- Clinical Pathology Diagnose disease based on the laboratory analysis of bodily fluids, such as blood, urine and tissues.
Developmental and Reproductive Toxicology (DART)
- Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.
Discovery Chemistry
- Elemental Analysis Determine the elemental composition of compounds, biomolecules, and pharmaceuticals.
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Disease Models
- Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
- LCMV Mouse Use a single animal species to create disease models for virus-induced immunity and immunopathology.
- Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
- Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
DNA & RNA
- Amplified Fragment Length Polymorphism Detection Detect DNA polymorphisms based upon restriction enzyme digestion and PCR.
- DNA Extraction Extract DNA from an original source.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
- RNA Extraction Isolate total RNA or mRNA from cells or tissues
General in vivo Toxicology
- General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
- IV Toxicology Test the toxicological effect of IV delivery of drug candidate.
- Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
- Repeat Dose Toxicity Study - Monkey / Non-human Primate Conduct a repeat dose study in monkey/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Toxicity Study - Monkey / Non-human Primate Conduct a single dose study in Monkeys and Non-human Primates to determine the toxicokinetic behavior of your compound.
- Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.
Show all 7 in General in vivo Toxicology
- Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.
In Vitro Assays
- Antivirals Measure anti-viral activity in biochemical and cell assays.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
Show all 11 in In Vitro Assays
- Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- SARS-CoV-2 (COVID-19) Assays Search for Available SARS-CoV-2 Assays
- Serine Protease Assay Detect apoptosis by measuring protease activity.
- WBAL (Whole Body AL) Whole Body Autoradioluminography (WBAL) and related services can assist you in determining the metabolic fate of your test agen...
In Vitro Toxicology
- Mouse Lymphoma Assay Assay for DNA damage in cells exposed to test substances.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Medical Communications
- Toxicology Reports Create pre-clinical toxicology reports.
Model Development
- Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
Non-Human Biospecimen
- Monkey / Non-Human Primate / NHP Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
- Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Oncology Models
- Experimental Metastatic Models Measure therapeutic endpoints in animal models of experimental metastatic cancer.
- Gene Modified Mice Create spontaneous tumor models without using a xenograft or drug treatment.
Other Specialty Toxicology
- Viral Testing Characterize viral products for functional activity and possible contamination.
Product Orders
- BioTx General Biotherapeutics analyze therapeutics and drugs via biological means and recombinant DNA. Pre-clinical sample bioanalysis and le...
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- Protein Binding Determine drug-protein binding interactions
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein Post-translational Modification Analysis Measure glycosylation, phosphorylation, sulfation, ubiquitination, methylation and acetylation.
Show all 9 in Protein Sciences
- Proteomics Do large-scale experimental analysis of proteins focused on understanding structure and function.
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
REACH Services
- OECD 403: Acute Inhalation Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation.
- OECD 436: Acute Inhalation Toxicity – Acute Toxic Class Method The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according...
- OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...
- OECD 476: In Vitro Mammalian Cell Gene Mutation Test (Mouse Lymphoma Assay) Determine if a compound is mutagenic by using cultured mammalian cells.
- OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
- OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.
Safety Pharmacology
- CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
- Immunotoxicity Measure effects of drugs on immune function, allergic hypersensitization and autoimmune toxicity.
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
- Tissue Cross Reactivity Assess the toxic effects of humanized monoclonal antibodies in 33 normal types recommended by the FDA.
Specialty Dosing Routes
- Dermal Toxicology Assess toxicity in rodent dermal testing models.
- Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
- Repeat Dose Inhalation Study - Other Species Conduct a repeat dose inhalation study in other species to determine the toxicity and toxicokinetic behavior of your compound.
- Repeat Dose Inhalation Study - Rat Conduct a repeat dose inhalation study in rats to determine the toxicity and toxicokinetic behavior of your compound.
- Repeat Dose Intravenous Infusion Study - Monkey / Non-human Primate Conduct a repeat dose intravenous infusion study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
- Single Dose Acute Inhalation Study - Other Species Conduct a single dose inhalation study in other species to determine the toxicokinetic behavior of your compound.
Show all 8 in Specialty Dosing Routes
- Single Dose Acute Inhalation Study - Rat Conduct a single dose inhalation study in rats to determine the toxicokinetic behavior of your compound.
- Single Dose Acute Intravenous Infusion Study - Monkey / Non-human Primate Conduct a single dose intravenous infusion study in monkeys/non-human primates to determine the toxicokinetic behavior of your compound.
Target Animal and Human Food Safety
- Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.
Other services
- New Request
Service areas:
Biology
Chemistry
DMPK
Pharmacology
Toxicology
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
IITRI provides GLP compliant pre-clinical toxicology, efficacy, PK and ADME services, safety assessment including genotoxicity, inhalation studies, animal biosafety level 2 and 3 capabilities and analytical chemistry services. As a Contract Research Organization located just south of Downtown Chicago, our Toxicology, Inhalation Toxicology, Analytical Chemistry, Microbiology, Molecular Biology and Cancer Biology Divisions would be more than happy to tackle any of your challenges and make them our next priority. The IITRI Project Team has extensive experience in the performance...
Show the full description
IITRI provides GLP compliant pre-clinical toxicology, efficacy, PK and ADME services, safety assessment including genotoxicity, inhalation studies, animal biosafety level 2 and 3 capabilities and analytical chemistry services. As a Contract Research Organization located just south of Downtown Chicago, our Toxicology, Inhalation Toxicology, Analytical Chemistry, Microbiology, Molecular Biology and Cancer Biology Divisions would be more than happy to tackle any of your challenges and make them our next priority. The IITRI Project Team has extensive experience in the performance of protocol-driven toxicology studies and in the conduct of more specialized investigations that are designed to integrate pharmacologic and organ-specific toxicologic mechanisms into an overall preclinical evaluation of a new drug. Over the past 10 years, IITRI scientists have become extensively involved in studies of genomics and proteomics, and are currently performing programs in which microarray, PCR, and other molecular data have been integrated into safety assessments.
- Website
- www.iitri.org
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