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TheraIndx Lifesciences pvt ltd

TheraIndx Lifesciences pvt ltd is listed as a small business research supplier in the Scientist.com network, with 3 sites in 1 country.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 3

Countries 1

Type of company: Small business

Agricultural Sciences Research & Development

Bacteriology PCR and MS-Based Bacterial Identification

Antibodies

Antibody Therapy Efficacy In vivo assessment of monoclonal/bispecific antibody efficacy in a humanized mouse
Immunodetection Use antibodies to identify a protein or antigen.
In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Monoclonal/Polyclonal Antibody Development Develop a monoclonal and/or polyclonal antibody.
Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
Polyclonal/Monoclonal Antibody Production Generate polyclonal or monoclonal antibodies in a range of animal species, over-express antibodies in cultured cells.

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Rabbit Monoclonal Antibody Development Develop monoclonal antibodies using rabbit as the host animal.
Recombinant Antibody Production Request services related to antibody production services.
Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.

Biomarkers

Anatomic Pathology Do macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues.
Antimicrobial Effectiveness Testing Measure the efficacy of anti-microbial preservatives added to a product.
Antioxidant Assays Use biochemical, cell-based or in vivo assays to measure total antioxidant capacity.
Autoantibody Testing Screen for the presence of an autoimmune disorder.
Basic Metabolic Profiling Set up assays that monitor drug metabolite formation after administration of drug to an animal model or patient.
Biomarker Analytical Validation Assess and optimize the characteristics of a candidate biomarker to ensure reproducibility and consistency.

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Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
Biomarker Clinical Validation Evaluate the predictive ability of a candidate biomarker for a disorder.
Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
Clinical Chemistry Measure analytes in serum, plasma, cells, tissue lysates or other biological materials.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
Endocrine Assays Use biochemical, cell based or in vivo assays to measure the concentration of hormones.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Focus Forming Assay Use colorimetric or immunofluorescence-based readouts to quantify virions prior to any plaque formation.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunophenotyping Separate cell types based on their expression of biomarkers or based on their individual and unique expression patterns.
In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
Large Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Metabolomics Biomarker Discovery Identify and quantitate metabolite biomarkers in blood, urine, CSF and bodily fluids.
MultiOmyx Molecular Pathology Tumor Analysis Assess multiple proteins from a single tissue section at a single-cell level.
Multiplex Circulating miRNA Assay Profile miRNAs directly from just 10 μl of crude biofluid or 0.1 ng of purified RNA.
Pharmacodynamic Biomarkers Discovery Identify candidate biomarkers indicative of the therapeutic outcome of a drug-target interaction.
Plaque Assays Determine infectious viral titer using plaque-forming units or purify viral stocks.
Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
Prognostic Biomarkers Discovery Identify candidate biomarkers representative of disease progression without treatment.
Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Solid Tumor CDx Design and validate companion diagnostics for solid tumors that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Whole Transcriptome Amplification Amplify total RNA from a single cell.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

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Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Bacterial Cell Culture Culture and Grow bacterial cells.
Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
In Vitro Hydrogel-Based Culture of PDXs Enable the extended laboratory culture of cancer PDXs and other primary cells in 3D.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.

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Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
Lab On The Skin - The Sweat Analysis Platform Use a skin-like microfluidic wearable device to measure sweat production in response to exercise.
Mycobacterium Screening Detect and distinguish between mycobacterium strains and species.
Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.

Chemical and Compound Analysis

Chemical Stability Measure the stability of small molecules in solution.
Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Process Residual Impurities Detection Measure trace levels of impurities.
Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.

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Structural Chemistry Examine the relationship between protein structure and function.

Chemistry, Manufacturing and Controls (CMC)

Advanced intermediates Sourcing advanced intermediates
API manufacturing process development, tech transfer and validation API manufacturing process development, tech transfer and validation
Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
IND Enabling Package Request a package of Investigational New Drug (IND) Enabling Studies from our group of trusted suppliers that have enrolled in our IND-Enabling Package Program.
Integrated Small Molecule Package Process an entire Small Molecule/Compounds Pipeline Project including: Compound Synthesis or Purchase, Compound Analysis/Testing, In Vitro Assays, and Formulation/Reformulation from our bundle of suppliers
Subcellular Fraction Test System Obtain human, minipig, mouse, or rat dermal microsomes as in-stock standard test systems for the development of safer topical and transdermal products.

Clinical Consulting

Biometrics Consulting Apply statistics and mathematics to drug discovery, clinical trials, and data analysis.

Clinical Trials

Bioequivalence Studies Assess the expected biological equivalence of two proprietary preparations of a drug.
Clinical Research Services Determine the safety and effectiveness of medications and medical devices.
Comparator Drug Sourcing Streamline new drug development and clinical trials by comparing the efficacy of an experimental drug to a comparator drug.
Consumer Healthcare Product Trials Conduct clinical research to ensure the safety and efficacy of consumer healthcare products used for oral care, skin care, nutrition, and hair care.
Investigator Recruitment Enlist clinical research experts to assist in investigator selection, recruitment monitoring and database evaluation.
Patient Recruitment Recruit and retain patients for clinical trials.

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Site Selection Select clinical trial sites with clinicians who recruit, enroll, treat and evaluate trial patients.
Statistical Analysis Planning Technical and detailed elaboration of the principal features of the analysis described in the protocol, and includes detailed procedures for executing the statistical analysis of the primary and secondary variables...
Virtual Clinical Trial Monitoring Platform This digital research platform allows researchers to monitor their clinical trials remotely.

Companion Diagnostics

Cervical Cancer CDx Design and validate companion diagnostics for cervical cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Osteoarthritis CDx Design and validate companion diagnostics for osteoarthritis that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Pancreatic Cancer CDx Design and validate companion diagnostics for pancreatic cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Rheumatoid Arthritis (RA) CDx Design and validate companion diagnostics for RA that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

Data Science/Bioinformatics

Biostatistical Design Use statistics to ensure appropriate pre-clinical and clinical study design.
Clinical Biomarker Analysis An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Clinical Companion Diagnostics Analysis The process of finding patients who are likely to respond positively to a drug and designing a diagnostic tool to identify this group of patients before or with a therapy.
Clinical Data Analysis Analysis that helps you make sense of your clinical data
Clinical Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data.
Clinical Data Science and Modeling A process that helps make sense of your clinical data

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Clinical In Silico Drug Dynamics The process to understand drug dynamics by computer analysis and simulation.
Clinical In Silico Genomics/Transcriptomics Data Analysis A process that helps make sense of your omics data
Clinical Responder Analysis, Patient Stratification The process of identifying patients that are more likely to respond positively to a drug.
Clinical Software Tools Software designed to serve the needs of clinical research groups.
Clinical Trial Integration Analysis The process of combining data from multiple clinical trials to understand categories of drugs and drug behavior in a more global way.
Discovery Biomarker Analytics An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Discovery Compound Screening Analytics Screening of an entire compound library directly against the drug target or in a more complex assay.
Discovery Data Analysis Analysis that helps you make sense of your discovery data
Discovery Data Integration The process of combining different complex data types together to make it easier to understand or analyze.
Discovery Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data for its users.
Discovery Data Science and Modeling A process that helps make sense of your discovery data
Discovery Databases Databases specifically designed for drug discovery use.
Discovery Drug Response Simulation Analytics Simulation of how a drug responds in different environments, from molecular to population studies.
Discovery In Silico Drug Dynamics Develop In Silico model of a drug candidate with a biological system with applications such as Pro-drug Predictions, ADME-PK Due Diligence, Brain-Barrier Permeability Simulation, Drug Absorption Simulation, In Silico...
Discovery In Silico Genomics/Transcriptomics Data Analysis A process that helps make sense of your Genomics/Transcriptomics data
Discovery In Silico Proteome Analysis Used to understand the global protein environment, specifically drug-protein interactions.
Discovery Omics Analytics A process to analyze various omics data (genomics, transcriptomics, proteomics, metabolomics, etc.) This can include the integration of different omics data. Helps to better understand the molecular environment...
Discovery Predictive Analytics Analytical approaches to predict how a drug target behaves in a given environment.
Discovery Software Tools Software designed to serve the needs of discovery research groups.
Discovery Statistical and Mathematical Modeling Use mathematical variables and equations to establish relationships between data.
In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
In Silico Drug-Drug Interactions Use computational tools to predict pharmaceutical, pharmacodynamic or pharmacokinetic drug-drug interactions to maximize drug regimen safety.
In Silico Epigenetic Compound Library Screening Use computer-aided methods to discover new compounds against key regulators of epigenetic signaling.
Proteome Data Analysis Find tools for analysis of homology and similarity, protein function and structural properties.
RWE/HEOR Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data.
RWE/HEOR Data Science and Modeling A process that helps make sense of your clinical data
RWE/HEOR Drug Response Analysis A process to understand how a population is responding to a drug, specifically if there are any adverse events.
RWE/HEOR Machine Learning/AI Complex analytical approaches to find patterns and make predictions in RWE/HEOR projects
RWE/HEOR Market Analysis A process to understand how a drug is performing in the market and possible opportunities in the market
RWE/HEOR Software Tools Software designed to serve the needs of RWE/HEOR research groups.
Translational Bioinformatics Different analytical approaches that make, store, and analyze complex biological data.
Translational Biomarker Discovery An approach to finding markers that change in response to a drug or that identify a group that responds favorably to a specific therapy. These can be omics, molecular, histologic, radiologic, etc.
Translational Data Analysis Analysis that helps you make sense of your translational data
Translational Data Curation Generally, human curation of acquired data to assess the quality and reliability of different data.
Translational Data Harmonization and Integration Process to combine different data together for better understanding and analysis of the integrated data.
Translational Data Knowledge Extraction Analytical approaches to extract data from different sources like publications, databases, etc. 
Translational Data Management A process that includes acquiring, validating, storing, protecting, and processing required data to ensure the accessibility, reliability, and timeliness of the data.
Translational Data Science and Modeling A process that helps make sense of your translational data
Translational In Silico Genomics/Transcriptomics Data Analysis A process that helps make sense of your omics data
Translational Machine Learning/AI Complex analytical approaches to find patterns and make predictions in drug discovery projects.
Translational Omics Analytics A process to analyze various omics data (genomics, transcriptomics, proteomics, metabolomics, etc.) This can include the integration of different omics data. Helps to better understand the molecular environment...
Translational Software tools Software designed to serve the needs of translational research groups.

Discovery Chemistry

Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
Compound Synthesis Services (IP-sensitive) Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.

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Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
Custom Libraries Find or synthesize mg to kg amounts of target-specific and target-agnostic compounds for HTS and biological profiling.
Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Fragment Libraries Find fragment libraries for screening against a protein or cellular target.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
In Silico Lead Optimization Use in silico design to enhance the ADME-PK properties of candidate drugs to maximize efficacy and safety.
LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
Natural Product Screening Screen large natural product collections for therapeutic activity.
QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.

Disease Models

Acute Kidney Failure Models Measure therapeutic endpoints in animal models of acute kidney failure.
Acute Liver Failure Models Measure therapeutic endpoints in animal models of acute liver failure.
Acute Lung Injury Models Measure therapeutic endpoints in animal models of acute lung injury.
Auto-immune Hepatitis Models Measure therapeutic endpoints in animal models with auto-immune hepatitis.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Bacterial Infection Models Measure therapeutic endpoints in animal models of bacterial infection.

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Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Bone Models Measure therapeutic endpoints in animal models of bone disorders.
Cardiovascular Metabolics Models Measure therapeutic endpoints in animal models of cardiovascular disorders.
Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
Cartilage Repair Models Measure therapeutic endpoints in animal models of cartilage repair.
Cataract Models Measure therapeutic endpoints in animal models of cataracts.
Chronic Kidney Disease Models Measure therapeutic endpoints in animal models of chronic kidney disease.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Comparative Pharmacology Compare drug responses across species for improved reliability in translational studies.
Cough Models Test the therapeutic efficacy of drug candidates in cough models.
Critical Care Models Diagnose and manage life-threatening conditions requiring sophisticated organ support and invasive monitoring.
Dermatology Models Measure therapeutic endpoints in animal models of dermatological disorders.
Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
General Pain Models Measure therapeutic endpoints in animal models of general pain.
Hair Growth Models Measure dermal histology, skin thickness, % anagen induction, hair proliferation and other hair growth markers.
Hematopoiesis Models Measure therapeutic endpoints in animal models of hematopoiesis.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.
Hepatitis C Virus Models Measure therapeutic endpoints in animal models of Hepatitis C virus infection.
Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
IGA Glomerulonephritis Models Measure therapeutic endpoints in animal models of IgA glomerulonephritis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Inflammatory Bowel Disease Models Measure IBD symptom severity, cytokine levels and body weight, and evaluate IHC and Ariol images.
Irritant Models Measure therapeutic endpoints in animal models of skin irritation.
Ischemia Models Measure therapeutic endpoints in animal models of ischemia.
Kidney Transplant Models Measure therapeutic endpoints in kidney transplant models.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Malaria Models Measure therapeutic endpoints in animal models of malaria.
Microbiome-Based Skin Disease Technology Modify the skin microbiome and deliver therapeutic proteins to the target.
Morris Water Maze Investigate spatial learning and memory in rodents.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Ocular Inflammation Models Measure ocular inflammation in models of eye disorders such as uveitis and keratitis.
Olfactory Testing Models Measure therapeutic endpoints in animal models of olfactory function.
Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
Osteoarthritis Models Measure therapeutic endpoints in animal models of osteoarthritis.
Osteoporosis Models Measure therapeutic endpoints in animal models of osteoporosis.
OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pigmented Rabbit Use a single animal species to create one or more disease models for eye cancer.
Plasmodium-Infected Mosquitoes Order live sporozoite-infected Anopheles stephensi mosquitoes.
Receptor Occupancy Models Determine the effective dose and concentration needed to reach effective levels in a given tissue.
Respiratory Models Test therapeutic efficacy of drug candidate in respiratory disease model.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
Skin Graft Models Measure therapeutic endpoints in animal models of skin grafts.
Spinal Cord Injury Models Measure therapeutic endpoints in models of spinal cord injury.
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Tissue Rejection Models Measure therapeutic endpoints in animal models of tissue rejection.
Viral Infection Models Measure therapeutic endpoints in animal models of viral infection.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.
Xenografts Evaluate drug candidate in tissue graft or organ transplant model.

DNA & RNA

Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genotyping Examine a DNA sequence to identify specific genetic varients .
miRNA sequencing Identify miRNAs by Next Generation Sequencing and bioinformatic analysis.
qPCR Analysis Measure the accumulation of PCR products in real time.

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Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Services Whether you’re isolating total RNA for whole genome expression analysis by microarray or setting up high content screening by s...
Tissue Microarray Screen large numbers of tissues for the presence or absence of specific molecular markers.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.

Effectiveness

Antimicrobial Pharmacodynamics Ascertain the effectiveness of an antimicrobial compound and test levels of antibiotic resistance against specific bacterial pathogens.
Bioequivalence Studies for Veterinary Drugs Assess the expected biological equivalence of two proprietary preparations of a veterinary drug.
Field Dose Confirmation Studies Conduct an in vivo study to confirm the effectiveness of a selected drug dose in actual field conditions.
Field Dose Determination Studies Examine the effectiveness of various therapeutic concentrations and durations against natural infections under a variety of field conditions.
In Vitro Dose Determination Tests Determine the most appropriate effective drug dosage regimen(s) in vitro.
Laboratory Dose Confirmation Studies Conduct in vivo studies to confirm the effectiveness of a selected drug dose in the lab.

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Laboratory Dose Determination Studies Compare the effectiveness of three non-zero therapeutic concentrations for various durations to a non-medicated control group, and a non-medicated uninfected control group.
Minimum Bactericidal Concentration (MBC) Test Assess the bactericidal activity of a test compound.
Veterinary Clinical Field Trials Conduct single- or multi-site clinical trials according to VICH/GCP guidelines in livestock, poultry, and domestic pet species.

Environmental Assessment

Soil Dissipation Studies Find out how products degrade and dissipate in soil under typical use conditions.

Food Safety & Regulations

Pseudomonas aeruginosa Testing Use molecular, immunological or cultured methods to confirm the presence or absence of P.aeruginosa in samples from food, water or processing surfaces.

General in vivo Toxicology

Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
General Toxicology Use in vivo models to assess acute and sub-acute toxicity as well as chronic and sub-chronic toxicity.
Nonclinical Study Management Provide nonclinical study management services to pharmaceutical and biotech companies. The services can be customized to meet the clients needs.
Oral Toxicology Use toxicity studies in animals to evaluate the oral toxicity of a drug candidate.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by a single administration in a 7 day period.

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Single Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by a single administration in a 7 day period.

Human Biological Samples

Custom PDX models For requesting Custom PDX models
Existing PDX models For requesting Existing PDX models
HBS Alzheimer's Acquire fresh, frozen, or fixed Alzheimer's tissues or other related Alzheimer's HBS.
HBS Autoimmune Diseases For requesting Autoimmune Diseases HBS.
HBS Diabetes For requesting HBS Diabetes.
HBS NASH For requesting HBS NASH

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HBS Viral Infections For requesting Viral Infection HBS
Human Biopsy Cell Models Request human biopsy cell models.
Human iPSC's For requesting human sourced induced pluripotent stem cells.
Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...

In Vitro ADME

Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
Cell Fractionation Isolate organelles and subcellular components.
Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.

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CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
CYP Isozyme Mapping Determine the isozymes of cytochrome P450 (CYP450) involved in the metabolism of a drug candidate.
Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro ADME in Vitro ADME services
Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Metabolite Identification and Profiling Estimate drug candidate metabolites after administration of drug to an animal or human subject.
Metabolite Quantification Quantify drug metabolites formed after drug administration to an animal model or patient.
Metabolite Structural Elucidation Use analytical tools to characterize metabolite structure.
Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Nasal Permeability Test for passive diffusion and active transport in nasal permeability models.
Non Isotopic Labeling Track unlabeled macromolecules through a metabolic pathway or cell.
Ocular Permeability Measure passive diffusion and active transport of drugs across confluent ocular epithelial cells.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
Reactive Metabolite Ensure that your drug candidate is not generating toxic reactive metabolites in vivo.
Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
Reference Standards Find reference standards for assays, tests and services.
Skin Permeability Use human skin models to determine transdermal delivery and percutaneous absorption of pre-clinical drugs.

In Vitro Assays

3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
3Screen™ 3D In Vitro Services 3Screen™ Platform enables complete 3D cell culture characterization.
Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Biosensor Assays Evaluate biological activity of new compounds, detect toxic metabolites or monitor biomarkers.

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Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
Cell Proliferation Measure cell number, cell viability and cell division.
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
Endpoint Dilution Assay (TCID50) Assay Determine the viral titer to induce cell death in half the cell population of an inoculated tissue culture.
Glucose Release Assay Determine free glucose levels in biological samples.
Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Human Immuno-deficiency Virus Infection CDx Design and validate companion diagnostics for HIV infection that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.
Hydroxyproline Assays Use biochemical, cell based or in vivo assays to quantify hydroxyproline or collagen in a sample.
Immunofocus™ Predict the response to anti PD1/PDL1 directed therapies.
ImmunoSEQ Assay Unmask the identity of millions of T- and B-cell receptors in a single sample using bias-controlled multiplex PCR amplification, high-throughput sequencing, and sophisticated bioinformatics.
In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro SPF (Sun Protection Factor) Testing Use in vitro test methods to measure the UVA protection performance of sun protection products.
Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
Microbiology Study microbes and their role in human health.
Organoid Screening Assay Evaluate the effects of various substances, such as drugs or genetic modifications, on organoids.
Pathway Mapping Define mechanisms of action by analyzing protein pathways affected by drug treatment.
SARS-CoV-2 (COVID-19) Assays Search for Available SARS-CoV-2 Assays
Virus Detection Assays Use ultra-sensitve methods to reliably detect low level viruses.

In Vitro Pharmacology

Anaplastic lymphoma kinase (ALK) Assays Use biochemical, cell based or in vivo assays to measure ALK enzyme activity.
B-Cell Lymphoma 2 (BCL-2) Assays Use biochemical, cell based or in vivo assays to measure BCL-2 protein activity.
Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Assays Use biochemical, cell based or in vivo assays to measure CTLA-4 receptor activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.

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Extracellular signal Regulated Kinase Assays Use biochemical, cell based or in vivo assays to measure ERK enzyme activity.
Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
HuGEMM - Immuno-Oncology Model Evaluate human-specific therapeutics for checkpoint inhibitors, including anti-human PD-1, anti-human PDL-1, and anti-human CTLA-4 antibodies.
Human BCL Assays Use biochemical, cell-based or in vivo assays to measure BCL activity.
Human Epidermal growth factor Receptor (HER) Assays Use biochemical, cell based or in vivo assays to measure HER receptor activity.
Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
In Vitro Cardiovascular Models Measure stimulation and inhibition of lipolysis, adipogenesis and endothelial cell migration.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Mammalian Target of Rapamycin Complex Assays Use biochemical, cell based or in vivo assays to measure mTORC enzyme activity.
Methyltransferase Assays Use biochemical, cell-based or in vitro assays to measure methyltransferase activity.
Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
Oxidase Assays Use biochemical, cell-based or in vivo assays to measure oxidase activity.
Phosphatase Assays Use biochemical, cell-based or in vitro assays to measure phosphatase activity.
Phosphatidylinositol 3-Kinase (PI3K) Assays Use biochemical, cell based or in vivo assays to measure PI3K enzyme activity.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
Programmed Cell Death-1 (PD-1) Assays Use biochemical, cell based or in vivo assays to measure PD-1 receptor activity.
Protein Kinase B (Akt) Assays Use biochemical, cell based or in vivo assays to measure Akt enzyme activity.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Raf Assays Use biochemical, cell based or in vivo assays to measure Raf enzyme activity.
RAS Assays Use biochemical, cell based or in vivo assays to measure RAS enzyme activity.
Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
Target Characterization Characterize potential drug targets during the drug discovery process.
Target Identification Identify the target(s) of a biologically active substance.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
Transporter Assays Use biochemical, cell-based or in vitro assays to measure transporter target activity.
UDP-glucuronosyltransferases (UGT) Inhibition Assays Use biochemical, cell-based or in vivo assays to measure UDP-glucuronosyltransferase activity.
Vascular Endothelial Growth Factor (VEGF) Assays Use biochemical, cell based or in vivo assays to monitor competitive or non-competitive binding of VEGF ligand.
Vascular Endothelial Growth Factor Receptor (VEGFR) Assays Use biochemical, cell based or in vivo assays to measure VEGF receptor activity.

In Vitro Toxicology

Cytotoxicity Test for effects on cell viability and proliferation
Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.

In Vivo ADME

Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
Chronic Bile Duct Cannulation (BDC) Study - Dog / Canine Conduct a bile duct cannulation (BDC) study in dogs/canines to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Monkey / Non-human Primate Conduct a bile duct cannulation (BDC) study in monkeys/non-human primates to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Other Species Conduct a bile duct cannulation (BDC) study in other species to support the absorption, distribution, metabolism and excretion profiling of your compound.
Chronic Bile Duct Cannulation (BDC) Study - Rat Conduct a bile duct cannulation (BDC) study in rats to support the absorption, distribution, metabolism and excretion profiling of your compound.
In Vivo Radiolabeled Metabolism Determine the qualitative and quantitative metabolism and/or degradation of an active ingredient in animals.

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Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Minipig Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in minipigs.
Mass Balance Study - Monkey / Non-human Primate Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in monkeys/non-human primates.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.
Milk Secretion Study - Other Species Conduct a study to determine the extent of milk secretion of your radioactive compound in other species.
Milk Secretion Study - Rat Conduct a study to determine the extent of milk secretion of your radioactive compound in rats.
Ocular Distribution Study - Dog / Canine Conduct a study to determine the distribution of your compound in ocular tissues of the dog/canine.
Ocular Distribution Study - Other Species Conduct a study to determine the distribution of your compound in ocular tissues of other species.
Ocular Distribution Study - Rabbit Conduct a study to determine the distribution of your compound in ocular tissues of the rabbit.
Ocular Distribution Study - Rat Conduct a study to determine the distribution of your compound in ocular tissues of the rat.
Placental Transfer Study - Other Species Conduct a study to determine the extent of placental transfer in other species by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Placental Transfer Study - Rabbit Conduct a study to determine the extent of placental transfer in rabbits by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Placental Transfer Study - Rat Conduct a study to determine the extent of placental transfer in rats by assessing the radioactivity of your compound in fetal tissue and maternal blood.
Quantitative Whole Body Autoradiography (QWBA) Determine the tissue distribution of a radiolabeled compound in Rodent and Non-Rodent Species.
Quantitative Whole Body Autoradiography (QWBA) - Rodent Species (Mouse, Rat) Conduct a study to determine the tissue distribution of your compound radiolabeled compound in rodent species.
Tissue Distribution Study the tissues in which a compound or its metabolites, accumulate.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…
Integrated In Vivo Services Package Process an entire In Vivo Project including: Dose Formulation, PK Screening, ADME-Profiling, Toxicology, Safety Pharmacology, DART, IND Filing from our bundle of suppliers.
Mass Balance Elucidate excretory pathways and organ distribution of a parent drug and metabolites
Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

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Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rabbit Conduct a pharmacokinetic screening study in rabbits that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Rat Efficacy Combination Use rat models to determine the anti-cancer efficacy and potential synergy of a drug candidate with a standard drug treatment.
Rat Efficacy Monotherapy Use rat models to determine the anti-cancer efficacy of a drug candidate compared to a positive control.
Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.

Lab Supplies, Facilities, and Equipment

Biobanking Store and track biological samples.

Management Optimization & Development Strategies

Big Data Computational assistance with analysis of large data sets to reveal patterns, trends and associations

Medical Communications

Medical Devices Biological Evaluation Report Audit Conduct a bio-compatibility evaluation of medical devices within the human body.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Custom Model Development Develop a custom disease model.
Disease Model Database For sourcing disease models.
Fresh Functional Human Tissue Ion Channel Activity Assays Use fresh functional human tissue to assess ion channel activity with various compounds.
hTME-3DX Screen and Verify™ A sophisticated and physiologically relevant 3D model that recapitulates the patient tumor microenvironment.
Human Precision-Cut Liver Slice Model Acquire a fresh phenotypically-accurate model to study human liver behavior.

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Human Precision-Cut Lung Slice Model Acquire a fresh phenotypically-accurate model to study human lung behavior.
In Silico PK-PD Modeling Quantitative modeling and simulations correlation of pharmacokinetic and pharmacodynamic endpoints in support of preclinical and clinical development.
Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
PBMC Humanized Mice Study and evaluate compounds for infectious diseases and graft rejection.
Pre-clinical Animal Surgery Conduct surgey in animals used as pre-clinical models.
SCID Mouse Use a single animal species to create one or more disease models for spontaneous and metastatic cancer and cachexia.
SCID/BG Mouse Use a single animal species to create one or more disease models for metastatic cancer.
Sprague Dawley Rat Use a single animal species to create one or more disease models for cachexia.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.
Zebrafish Animal Model Model human disease and development in zebrafish.
Zucker Rat Use a single animal species to create one or more disease models for cachexia.

Nanotechnology

Nanoparticle Synthesis Create nano-level structures with unique features.

Non-Human Biospecimen

Guinea Pig Biofluids Acquire fresh or frozen biofluids including but not limited to whole blood, plasma, serum, CSF, milk, urine, feces, bile, semen, aqueous humor, vitreous humor, saliva, tears, etc.
Guinea Pig Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Guinea Pig Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rabbit Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.
Rat Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Oncology Models

Angiogenesis Models Measure therapeutic endpoints in animal models of angiogenesis.
Animal Hypoxia Models Measure therapeutic endpoints in hypoxic animal models.
Athymic Mouse Use a single animal species to create one or more disease models for cachexia and spontaneous cancer.
Cachexia Models Measure therapeutic endpoints in animal models of cachexia.
Experimental Metastatic Models Measure therapeutic endpoints in animal models of experimental metastatic cancer.
Hematological Cancer PDX Design and validate companion diagnostics for hematological cancer that help select the most appropriate patients, identify patients at increased risk, or monitor treatment effectiveness.

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Immuno-PDX Utilize the patient-derived xenograft for drug response profiling and biomarker discovery of immuno-oncology drug candidates.
Leukemia PDX Measure therapeutic endpoints in patient-derived xenografts of leukemia.
Muscle Wasting Models Measure therapeutic endpoints in animal models of muscle wasting.
NCG Model Study tumor biology and immuno-oncology in the CRISPR/Cas9-generated immunodeficient mouse model.
Nervous System Xenografts Xenografts relating to the Nervous system. This includes samples from the Head, Neck, Brain, and Nerves.
Oncology Derived PDX Patient derived xenografts derived from various oncological samples. This includes, but is not limited to, samples from Lymphoma, Melanoma, and Leukemia.
Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Oncology Xenografts Xenografts derived from oncological samples.
Oral Xenograft Measure therapeutic endpoints in oral cancer models as well as cancer models related to the Pharynx.
Ovarian Cancer Mouse Measure therapeutic endpoints in animal models of ovarian cancer.
Renal Xenograft Measure therapeutic endpoints in renal models of cancer.
T11 (Breast Cancer) Measure therapeutic endpoints in animal models of breast cancer.
Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.

Other Specialty Toxicology

Microbial Testing Test samples for microorganisms, identify species, do bioburden analysis and measure endotoxin levels (LAL).

Pharmacology

In Vivo Pharmacology Study the effects of drug candidates in animal models

Protein Sciences

Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
Cytokines Find recombinant cytokines or cytokine assays.
ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
Protein Binding Determine drug-protein binding interactions
Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.

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Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
Western Blots Detect specific proteins in a sample of tissue homogenate or extract.

Raw Materials

Surfactants - Amphoterics, Anionics, Betaines, Ethoxylated Glycerine, Nonionics Acquire surfactants, such as amphoterics, anionics, betaines, ethoxylated glycerine, and nonionics, to use as ingredients in consumer healthcare products.

REACH Services

In Vitro REACH Services Perform skin or eye irriation tests, sensitivily and geneotoxicity tests
In Vitro Skin Sensitization Determine whether a drug or cosmetic product may cause dermal sensitization.
OECD 402: Acute Dermal Toxicity This method provides information on health hazard likely to arise from short-term exposure to a test chemical by dermal route.
OECD 405: Acute Eye Irritation/Corrosion This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye.
OECD 406: Skin Sensitisation This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application.
OECD 410: Repeated Dose Dermal Toxicity: 21/28-day Study This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance.

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OECD 412: Subacute Inhalation Toxicity: 28-Day Study This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data...
OECD 413: Subchronic Inhalation Toxicity: 90-day Study This revised Test Guideline 413 (TG 413) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a period of 90 days, and to provide data for quantitative...
OECD 426: Developmental Neurotoxicity Study A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development.
OECD 431: In Vitro Skin Corrosion: Human Skin Model Test The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight...
OECD 432: In Vitro 3T3 NRU Phototoxicity Test Test the cytotoxic effects of chemical substances and environmental samples on cell membranes.
OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 487: In Vitro Mammalian Cell Micronucleus Test Assess whether a test substance induces chromosomal changes in cultured cells.
OECD 489: In Vivo Mammalian Alkaline Comet Assay Measure the mitogenic and genotoxic potential of test compounds.

Real World Evidence & Data

RWD - COVID-19 Data from COVID-19 patients, can include diagnosis, treatment, among others.
RWE/HEOR Data Analysis Analysis that helps you make sense of your RWE/HEOR data

Safety Pharmacology

CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
Repeat Dose Neurotoxicity Study - Rat Conduct a repeat dose study in rats to determine the neurotoxicity of your compound.
Respiratory Toxicology Assess difficulty breathing, altered respiration, blood gas changes and blood pH issues due to adverse reactions.

Scientific Data Services

Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Cancer Systems Biology Convert complex molecular data obtained from high-throughput technologies to deducible information.
Data and Text Mining Derive structured data from free text in order to become accessible for data-mining algorithms.
Database Integration Convert bioinformatics results from multiple data sources (DSs) into a single operational format.
Discovery Computational Systems Biology Model the interaction of biological system with drug candidates.
Epigenomics Data Analysis Quantify and analyze DNA methylation and/or DNA binding protein data sets.

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Genome Data Analysis Analyze genomic DNA, RNA and protein sequence data.
Large Language Models Use of Large Language models in target discovery, clinical trial design and development, analysis of clinical trial data and regulatory submissions. Services are tailored to the problem, specific context of biopharma.
Marker Analyses Identify associations between genetic markers and traits of interest to determine markers responsible for human diseases.
Metabolomics Data Analysis Use metabolites to identify any potential biomarkers or novel therapeutic targets that may play a role in the mechanisms responsible for the progression of a disease.
Metagenomics Data Analysis Deconvolute the genetic content of genomes contained in environmental samples by utilizing whole genome sequencing techniques to provide insight into microbial communities and host phenotypes.
Molecular Dynamics Software Run simulations that determine time-dependent behaviors of molecular systems.
Molecular Phylogenetics Analyze hereditary molecular differences in genomic sequences to compare genomes.
Mutation Data Profiling Guide treatment decisions in cancer based on the identification of genomic mutations .
NGS: Next Generation Sequencing Data Analysis Use software to interpret data created by RNA-Seq, DNA-Seq, ChIP-Seq and DNA methylation experiments.
Omics Informatics Consulting Services for the analysis of large-scale molecular data sets.
Small RNA Gene Expression Quantify and analyze miRNA, piRNA, siRNA as well as other small nuclear RNAs from small-RNA-seq raw input data sets.
Software Tools Software tool for statistical analysis, data mining, genome annotation or NGS data analysis.
Systems Biomedicine Analyze complex interactions in biological systems with interdisciplinary scientific teams.
Systems Network Analysis Analyze and visualize molecular pathways including gene regulatory, protein-protein and drug-target networks.
Systems Pharmacology Understand how drugs interact with different molecular and cellular systems within biological models.

Specialty Dosing Routes

Chronic Inhalation Carcinogenicity Study - Rat Conduct a repeat inhalation dose, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Chronic Intranasal Carcinogenicity Study - Other Species Conduct a repeat dose intranasal, chronic carcinogenicity study in other species to determine the tendency of your compound to produce tumors.
Chronic Intranasal Carcinogenicity Study - Rats Conduct a repeat dose intranasal, chronic carcinogenicity study in rats to determine the tendency of your compound to produce tumors.
Dermal Toxicology Assess toxicity in rodent dermal testing models.
Inhalation Toxicology Measure toxicity by daily clinical observation, body weight, clinical chemistry, hematology, and terminal necropsy and pathology.
Repeat Dose Inhalation Study - Rat Conduct a repeat dose inhalation study in rats to determine the toxicity and toxicokinetic behavior of your compound.

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Repeat Dose Intranasal Study - Dog / Canine Conduct a repeat dose intranasal study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Mouse Conduct a repeat dose intranasal study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Other Species Conduct a repeat dose intranasal study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intranasal Study - Rat Conduct a repeat dose intranasal study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Repeat Dose Intravenous Infusion Study - Rats Conduct a repeat dose intravenous infusion study in rats to determine the toxicity and toxicokinetic behavior of your compound.
Single Dose Acute Inhalation Study - Rat Conduct a single dose inhalation study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Mouse Conduct a single dose intranasal study in mice to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Other Species Conduct a single dose intranasal study in other species to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intranasal Study - Rat Conduct a single dose intranasal study in rats to determine the toxicokinetic behavior of your compound.
Single Dose Acute Intravenous Infusion Study - Rats Conduct a single dose intravenous infusion study in rats to determine the toxicokinetic behavior of your compound.
Topical Dermal Toxicity and/or Toxicokinetic Study - Minipig Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to minipigs.
Topical Dermal Toxicity and/or Toxicokinetic Study - Mouse Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to mice.
Topical Dermal Toxicity and/or Toxicokinetic Study - Other Species Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to other species.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rabbit Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rabbits.
Topical Dermal Toxicity and/or Toxicokinetic Study - Rat Conduct a dermal study to determine the toxicity and/or toxicokinetic behavior of your compound when applied topically to rats.
Topical Ocular Toxicity and/or Toxicokinetic Study - Mouse Conduct a topical ocular toxicity study in mice to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Non-pigmented (New Zealand White; NZW) Conduct a topical ocular toxicity study in non-pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Pigmented (Dutch Belted, New Zealand Red) Conduct a topical ocular toxicity study in pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rat Conduct a topical ocular toxicity study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Target Animal and Human Food Safety

Target Animal Safety (TAS) Studies Evaluate potential harmful effects associated with the use of a new animal drug in a controlled setting.
Tolerance Studies Conduct tolerance studies on target animals of veterinary products.
Toxicity Test for Veterinary Drugs Use the drug at 10X the recommended dose for 3X the recommended duration to evaluate its safety.
Toxicokinetic Analysis Determine the drug concentration at which off-target or toxic effects occur.

Testing Services

ASTM E2315: Time-Kill Procedure (Antimicrobial Testing Study) Assessment of Antimicrobial Activity Using a Time-Kill Procedure
Bacterial Identification Testing Use biochemical and molecular methods to identify unknown microorganisms.
Bacterial Reverse Mutation Assay Test whether a cosmetic product or ingredient causes DNA mutations in bacteria.
CLSI M26-A: Minimum Bactericidal Concentration (MBC) Determine the lowest concentration of an antimicrobial agent that is lethal to the target bacteria in vitro.
Cosmetics Aerobic Plate Count Determine the level of aerobic bacteria present in a cosmetic or personal care product.
Cosmetics Anaerobic Plate Count Determine the level of anaerobic bacteria present in a cosmetic or personal care product.

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Ex Vivo Eye Irritation Test (EVEIT) Use optical coherence tomography (OCT) to monitor full-thickness recovery of corneal tissue.
Human Repeat Insult Patch Test (HRIPT) Examples of which include Topical Irritation, Allergenicity, Phototoxicity and Photoallergy testing.
In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.
In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Microbiological Sterility Testing Test the presence of viable microorganisms.
Ocular Corrosion Testing Use in vitro models to determine whether a product (or ingredient) can cause ocular corrosion.
Ocular Irritation Test Use human subjects to determine whether a cosmetic product or ingredient can cause ocular irritation.
OECD 435: Skin Corrosion Test - Membrane Barrier Method Use in vitro models to determine whether a cosmetic product or ingredient can cause skin corrosion.
OECD 439: Skin Irritation Test (SIT) Reconstructed Human Epidermis Test (RhE) Method - An in vitro testing method designed to identify chemicals and/or mixtures capable of inducing moderate skin irritation.
OECD 442C: Direct Peptide Reactivity Assay (DPRA) Determine whether a test article satisfies the protein-binding criterion for skin sensitizers.
OECD 442D: ARE-Nrf2 Luciferase Test An in vitro test method (KeratinoSensTM and/or LuSens) that models the second key event in the Adverse Outcome Pathway for Dermal Sensitization.
OECD 442E: Human Cell Line Activation Test (h-CLAT) In vitro skin sensitization test to predict skin sensitization potency.
OECD TG 492: Ocular Irritation Testing Use in vitro skin models to determine whether a product can cause dermal sensitization (e.g. EpiOcular Eye Irritation Test - EIT)
Phototoxicity and Photosensitization Screening Screen a consumer healthcare product for irritancy and/or allergy potential following exposure to UV light.
Phototoxicology Phototoxicity testing identifies and evaluates the potential of chemical agents to induce toxicity upon subsequent exposure to light.
Repeat Insult Patch Tests: Sensitisation Perform 100- and 200-subject patch tests to investigate sensitization (allergy) potential of a product following repeated exposure and challenge at a naïve skin site.
Single Ocular Instillation Test Determine if a “tear-free” claim can be substantiated for a cosmetic product.
Skin Elasticity Testing Measure the skin's ability to resist pressure (firmness) and its ability to return to its original position pre- and post-treatment.
Skin Lightening Product Test Measure qualitative and quantitative changes in skin pigmentation under the influence of the test sample.
USP 51 Cosmetic Preservative Efficacy Test Evaluate the antimicrobial stabilization of a cosmetic product as per USP 51.
USP <61> Microbial Limits Test Determine whether a substance or preparation complies with an established specification for microbiological quality.
USP <62> Microbial Limits Test Determine the presence or absence of specific microorganisms.

Other services

Labskin - 3D Skin Model Obtain a full-thickness human skin model.
New Request

India Bangalore, Nelamangala 3 sites

TheraIndx Lifesciences is a Preclinical CRO based in Bangalore, INDIA. offers wide range of animal disease models along with biology, PK/PD services from its State-of-the-art Vivarium with BSL2 Labs.

Website: www.theraindx.com

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