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SB Drug Discovery
SB Drug Discovery is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 2 service areas.
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Sites
1
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Cell Culture and Characterization
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
Show all 9 in Cell Culture and Characterization
- Insect Tissue Culture Grow insect cells.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Discovery Chemistry
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
Show all 82 services
Disease Models
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
- Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
- LPS Acute Response Models Measure therapeutic endpoints in acute models of inflammation.
- LPS Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
- OVA Lung Inflammation Models Measure therapeutic endpoints in animal models of inflammation.
- Pain Endpoints Models Measure therapeutic endpoints in animal models of pain.
Show all 8 in Disease Models
- Pain Models Test therapeutic efficacy of drug candidate in pain model.
- Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
DNA & RNA
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
- Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
Human Biological Samples
- FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
- Human Whole Blood Acquire fresh/frozen normal whole blood based on patient demographics and history.
In Vitro ADME
- HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell-based Screening Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.
- Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
Show all 11 in In Vitro Assays
- HTS Assay Development Develop assays to use in high throughput screening.
- Inflammation Assays Identify and validate pro- and anti-inflammatory molecules, recruitment inhibitors and chemotaxis modulators.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
- Oxidative Burst Examine the release of reactive oxygen species (ROS) from neutrophils and other immune cells.
- Serine Protease Assay Detect apoptosis by measuring protease activity.
In Vitro Pharmacology
- Bromodomain Assays Use biochemical, cell-based or in vivo assays to measure bromodomain activity.
- Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
- Chloride Channel Assays Use biochemical, cell-based or in vivo assays to measure chloride channel activity.
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
Show all 17 in In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- In Vitro Enzyme Activity Assay Development Develop new in vitro enzyme activity assays or modify existing ones.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
- Phosphodiesterase Assays Measure phosphodiesterase activity in biochemical and cell-based assays.
- Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
- Protease Assay Measure protease activity in biochemical and cell-based assays.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- Cardiac Channels Measure the arrhythmia producing potential of test compounds.
- Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
- Cytotoxicity Test for effects on cell viability and proliferation
- Cytotoxicity Testing Determine whether a cosmetic product or ingredient is toxic to in vitro cell cultures.
- hERG Inhibition Measure the arrhythmia-producing potential of test compounds.
Model Development
- Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Non-Human Biospecimen
- Mouse Microglia Acquire microglia isolated from the mouse brain.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- Cytokines Find recombinant cytokines or cytokine assays.
- Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
- Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
- Protein Engineering Alter the features or properties of a protein for a specific purpose.
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
Show all 11 in Protein Sciences
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein Purification Isolate native or recombinant proteins from a sample.
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
- Yeast Two Hybrid Search novel interactions or confirm hypothesized protein-protein interactions using pairwise assays.
Safety Pharmacology
- Off Target Effects Assess toxicities by body weight, clinical chemistry, hematology, urinalysis and terminal necropsy and pathology.
- Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Other services
- Biological Material For requesting cells and other propagatable material.
- New Request
Service areas:
Biology
Pharmacology
Where it operates
Sites by country, with the cities in each.
-
United Kingdom 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
SB Drug Discovery is a tri-divisional CRO offering expertise in recombinant protein expression (SB Protein Services), cell line development / off the shelf cell lines (SB Cell Line Development) and biochemical, cell based and in vivo assays against a broad range of targets including PDEs, ion channels, nuclear receptors, GPCRs and proteases (SB Screening & Assays).
In addition, SB Drug Discovery has specialized expertise in the field of inflammation and offers a broad panel of cell based and in vivo inflammatory assays including human blood-based assays.
- Website
- www.sbdrugdiscovery.com
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