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Premas Biotech
Premas Biotech is listed as a mid sized business research supplier in the Scientist.com network, with 2 sites in 1 country and 1 service area.
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Sites
2
Countries
1
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Agricultural Sciences Research & Development
- Gene Isolation and cloning Development of methods for isolation of gene(s) of interest.
- Vaccines Testing transgenic plants as promising systems for vaccine production.
Antibodies
- Antibody Detection Quantitate, localize and visualize proteins and other antigens.
- Antibody Humanization Increase an antibody's similarity to a variant produced naturally in humans.
- Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
- Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
- Custom Antibodies Design and produce polyclonal and monoclonal antibodies.
- In Vitro Monoclonal Antibody Production Generate monoclonal antibodies in vitro using cultured antibody-secreting hybridoma cell lines.
Show all 9 in Antibodies
- Phosphospecific Antibodies Create antibodies to detect phosphorylated protein targets.
- Polyclonal Antibody Production Generate polyclonal antibodies in vivo using evolutionary distant animal species.
- Single Chain Variable Fragment (scFv) Create an antigen-specific antibody derivative using a linker to join a heavy and a light variable chain.
Biomarkers
- Biomarker Clinical Utility Evaluate the potential clinical applications of a candidate biomarker.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Diagnostic Biomarkers Discovery Identify candidate biomarkers indicative of the presence of a disorder.
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
Show all 8 in Biomarkers
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Single Cell quantitative Real Time-PCR Assess gene expression levels and patterns in a single cell.
Show all 112 services
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
- Cell Line Construction Create new recombinant cell lines to exact specifications.
Show all 10 in Cell Culture and Characterization
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Custom 3D Microtissue Development Convert cell lines into highly functional 3D microtissues using scaffold-free self-assembly.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
- Yeast Cell Culture Grow yeast strains or species.
Chemical and Compound Analysis
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
Chemistry, Manufacturing and Controls (CMC)
- Bi-specific Antibodies Create a protein made of fragments of two monoclonal antibodies that bind to different antigens.
Data Science/Bioinformatics
- In Silico Protein Sequence Analysis Use software to predict protein structural and functional features and secondary structure components.
Discovery Chemistry
- Custom Synthesis Find or synthesize mg to kg amounts of target-specific and target agnostic compounds for HTS and biological screening.
- Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
Disease Models
- Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
DNA & RNA
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- cDNA library construction Generate a library of recombinant cDNA clones.
- Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
- DNA Library Screening Screen genomic or cDNA libraries for positive clones.
- DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
- DNA Products Find DNA products including gDNA, cDNA clones, vectors and constructs from mice, insects, yeast, bacteria and viruses.
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- DNA Sequencing Determine the nucleotide sequence of DNA samples.
- DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
- DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
- Expression Profiling Measure the the expression of thousands of genes at once to create a global picture of cellular function.
- Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
- Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
- PCR Mutagenesis Use polymerase chain reaction to create mutations in a cloned gene.
- Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
- Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Drug Development
- Large Molecule Drug Development Consulting Develop large molecule drugs and complex biologics that have a therapeutic effect.
Food Safety & Regulations
- Total Viable Count (TVC) Estimate the total living microbial populations present in a food or beverage sample to guarantee product quality.
General in vivo Toxicology
- Mammalian Toxicology Use toxicity testing models to carry out required FDA or REACH safety testing.
Human Biological Samples
- Human 3D cultures Provision of 3D culture of Human Primary Cells
In Vitro ADME
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
Show all 9 in In Vitro ADME
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Protein Binding Ultrafiltration Measure the rate at which unbound drug passes through a dialysis membrane that models epithelial barrier pore size.
In Vitro Assays
- Antivirals Measure anti-viral activity in biochemical and cell assays.
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Reporter Virus Particles (RVPs) - Dengue Neutralization Assay Use Dengue Reporter Virus Particles to measure neutralizing antibodies against each of the four Dengue serotypes.
In Vitro Pharmacology
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Show all 12 in In Vitro Pharmacology
- Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.
- Protease Assay Measure protease activity in biochemical and cell-based assays.
- Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
- Sodium Channel Assays Use biochemical, cell-based or in vivo assays to measure sodium channel activity.
- Target Characterization Characterize potential drug targets during the drug discovery process.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
Lab Supplies, Facilities, and Equipment
- Biobanking Store and track biological samples.
Medical Communications
- Investigational Medicinal Product Dossier (IMPD) and Investigational New Drug (IND) Dossier Develop and submit Investigational Medicinal Product Dossier (IMPD) and Investigational New Drug (IND) Dossier
- Medical Writing and Editing/Manuscript Development Communicate scientific, technical and health-related information to a range of audiences.
Oncology Models
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
Processing, Packaging, & Preservation
- Aerobic Fermentation Implement desirable microbial activity in oxygenated conditions to enhance or preserve food and beverage products.
- Pure Culture Fermentation Implement the desirable microbial activity of a specific microbial strain to enhance or preserve food and beverage products.
Protein Sciences
- Affinity Tag Purification Purify proteins under physiological conditions at their native cellular levels.
- Antimicrobial Peptide Synthesis Make a peptide with anti-microbial activities.
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
- Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
- Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
Show all 22 in Protein Sciences
- Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
- Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
- Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
- Neoantigen Development Develop neoantigens for oncological therapeutics for vaccine development.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
- Phage Display Use in vitro screening method to identify protein binding partners.
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
- Protein Products Find native and recombinant proteins and peptides.
- Protein Purification Isolate native or recombinant proteins from a sample.
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
- Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.
REACH Services
- OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
- OECD 473: In Vitro Mammalian Chromosomal Aberration Test Assess the ability of the test substance to cause structural chromosomal aberrations in cultured mammalian cells.
Scientific Data Services
- Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
Service areas:
Biology
Where it operates
Sites by country, with the cities in each.
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India 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Premas Biotech offers gene cloning and expression, protein purification, assay development, gene expression analysis, SNP genotyping, process development, scale up and raw material production (non cGMP or cGMP) services.
- Website
- www.premasbiotech.com
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