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Research supplier
InSphero
InSphero is listed as a mid sized business research supplier in the Scientist.com network, with 4 sites in 2 countries and 1 service area.
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Sites
4
Countries
2
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Custom 3D Microtissue Development Convert cell lines into highly functional 3D microtissues using scaffold-free self-assembly.
- Organotypic Culture Co-culture different cells to enable in vitro growth of an in vivo tissue or organ equivalent.
Developmental and Reproductive Toxicology (DART)
- Fertility and Embryonic Development Study (Segment I) Test drug candidate in Segment I toxicology services.
- Reproductive Toxicology Study adverse sexual function and fertility and examine teratogenicity of compounds.
Disease Models
- Cardiovascular Models Test the therapeutic efficacy of drug candidates in cardiovacular disease models.
- Drug-Induced Liver Injury (DILI) Toxicity Assays Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
Human Biological Samples
- 3D InSight™ Liver Microtissues Perform in vitro assessment of islet function for efficacy and toxicity testing.
- Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
- Custom PDX models For requesting Custom PDX models
- FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
- HBS Diabetes For requesting HBS Diabetes.
- HBS NASH For requesting HBS NASH
Show all 10 in Human Biological Samples
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- HBS: Human Biological Samples - VMS Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
- Human Organs-On-Chips Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
Show all 47 services
In Vitro ADME
- Cell Permeability and Absorbance Models Cell Permeability and Absorbance Model assay.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
In Vitro Assays
- 3D Cell Microscopy Assay Investigate cellular and subcellular events in three dimensional 3D cultures by using fluorescence microscopy.
- Cell Proliferation Measure cell number, cell viability and cell division.
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- Viral Clearance Assays Measure the capacity to remove or inactivate infectious agents during the manufacturing process.
In Vitro Pharmacology
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
- In Vitro Hepatotoxicity Assays Use in vitro assays to measure hepatoxicity-related activities.
Show all 8 in In Vitro Pharmacology
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
- Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
- Toxicology- in vitro Toxicity testing and model development in vitro on developmental and adult neurotoxicity
Model Development
- Custom Model Development Develop a custom disease model.
Oncology Models
- 3D Triculture Breast Cancer Model Use tricultures of breast cancer cell lines, hMSCs, and endothelial tubules for evaluating breast cancer progression.
- Oncology Models Use model organisms to test the therapeutic efficacy of cancer drug candidates.
- Xenograft Models Measure therapeutic endpoints in cancer models using tumor cells transplanted from a donor of a different species.
Testing Services
- In Vitro Oral Care Product Testing Perform in vitro oral care product testing of dental products to evaluate safety and performance, including assessment for cleaning, brushing, whitening, stain removal, erosion, abrasivity and sensitivity.
- In Vitro Toxicology Testing Non-animal testing employing US and international methodologies for determining irritation and other undesirable potentials.
Other services
- Integrated Human Biospecimen Package Utilize a Human Biospecimen Pipeline Package to process or characterize Human Biological Samples including: Sample Preparation, Histochemistry, Hybridization, Sequencing, Cell Based Assays, and Sample Bioanalysis from...
- New Request
Service areas:
Biology
Where it operates
Sites by country, with the cities in each.
-
Switzerland 2 sites
-
United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
InSphero produces organotypic microtissues in 96 well format for compound efficacy and toxicological assessments. This 3D culture technology is simple, highly cost-effective and avoids the use of interfering scaffold materials, making analysis more reliable.
- Professional associations
- MassBio, SOT, Society of Biomolecular Imaging and Informatics (SBI2), Society of Laboratory Automation and Screening (SLAS)
- Website
- www.insphero.com
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