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Synthelis Biotech
Synthelis Biotech is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 4 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Antibodies
- Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
- Antibody Products Purchase antibody, antibody pair kit or ELISA kit.
- Immunodetection Use antibodies to identify a protein or antigen.
Bioimaging
- Luminescence Imaging Monitor biological processes and pathologies using reporter proteins such as firefly and Renilla luciferase.
Biomarkers
- Immunoassays Create antibody-based assays for the identification and quantification of specific antigens.
Cell Culture and Characterization
- Signaling Pathways Find proteins, assays and custom reagents for the analysis of cell signaling pathways.
Chemical and Compound Analysis
- Circular Dichroism Examine the secondary structure and folding properties of proteins in solution.
- Dynamic Light Scattering Determine the size of particles and extent of molecular aggregation in a suspension.
- Electrophoresis Separate nucleic acids or proteins based on physical properties such as charge or mass.
- Ion Exchange Chromatography Separate and detect analytes.
- Isothermal Titration Calorimetry An ITC assay will be established and optimised for the affinity measurement of test substance to target molecule.
- Liquid Chromatography Separate substances using a mobile and stationary phase.
Show all 16 in Chemical and Compound Analysis
- MALDI-TOF Analysis Use mass spectrometry technique to analyze compound, biomolecules and large organic molecules.
- Protein Binding HPLC Uses high pressure liquid chromatography to separate protein-drug complexes.
- Protein Separation and Detection Separate proteins based on properties such as solubility, adsorption or size differences.
- Raman Spectroscopy Use spectroscopic technique to observe vibrational, rotational and other low-frequency modes in a system.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
- Size Exclusion Chromatography Separate and identify analytes based on their molecular size.
- Small Angle X-Ray Scattering Obtain low-resolution structures of biopolymers in solution using an x-ray beam.
- Solid State Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solid samples.
- Solution Nuclear Magnetic Resonance Identify molecular structure or impurities and assess product integrity of solution samples.
- Structural Chemistry Examine the relationship between protein structure and function.
Show all 64 services
Chemistry, Manufacturing and Controls (CMC)
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Discovery Chemistry
- LCMS Analysis Physically separate substances using liquid chromatography and mass spectrometry.
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
In Vitro Assays
- High Content Screening Analyze whole cells or components of cells with simultaneous readout of several parameters.
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- Fibroblast Growth Factor Receptor (FGFR) Assays Use biochemical, cell based or in vivo assays to measure FGF receptor activity.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
- Liposome Immunoassay Use immuno-liposomes for improved signal intensity and detection sensitivity compared to enzyme and fluorescent immunoassays.
- Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
Show all 8 in In Vitro Pharmacology
- Potassium Channel Assays Use biochemical, cell-based or in vivo assays to measure potassium channel activity.
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
Medical Communications
- Scientific Training Solutions Developing comprehensive educational programs and materials to ensure internal teams, field medical staff, or external partners are fluent in the therapeutic area and product data.
Nanotechnology
- Drug Delivery Technology Create microstructures that enhance drug metabolism properties.
- Liposomes Create artificial spherical vesicles that can be used as a vehicle for administration of drugs.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Analytical Ultracentrifugation Characterize the interactions and properties of macromolecules in solution.
- Antibody-Antigen Affinity Measurement Measure the binding kinetics of an antibody–antigen interaction.
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
- Integrated Protein Production Package Process an entire Protein Production Pipeline Project including: Gene/Oligo Synthesis, Cloning/Subcloning, Protein Expression, Protein Purification, Protein Analysis, and Protein Products from our bundle of suppliers
Show all 23 in Protein Sciences
- Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
- LCMS/MS Analysis Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.
- N-terminal Sequencing Determine the amino acid sequence of an intact protein from its N-terminus.
- Peptide/Protein Based Vaccine Production Create a peptide or protein antigen for use in artificial immunization.
- Peptide/Protein Products Purchase off-the-shelf protein or peptide products.
- Protein Binding Determine drug-protein binding interactions
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Protein Interaction Measure the interaction of a protein to other macromolecules or peptide ligands.
- Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
- Protein Products Find native and recombinant proteins and peptides.
- Protein Purification Isolate native or recombinant proteins from a sample.
- Protein Sequencing Determine the amino acid sequence of protein or peptide.
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
- X-Ray Crystallography Elucidate structures of biological macromolecules such as proteins and nucleic acids.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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France 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Synthelis is a French CRO specialized in the membrane protein production using cell free system from E.Coli lysate into liposomes. The cell free system allows us to produce quickly high quantity of protein without denaturation steps or having to deal with cellular biology issues such as: cytotoxicity, inclusion body, stable cell line generation delay. Including the liposome during the production process provides the perfect environment for the membrane protein to settle in, hence enabling a physiology close conformation of the protein. A large variety of target classes such as GPCRs, ion...
Show the full description
Synthelis is a French CRO specialized in the membrane protein production using cell free system from E.Coli lysate into liposomes. The cell free system allows us to produce quickly high quantity of protein without denaturation steps or having to deal with cellular biology issues such as: cytotoxicity, inclusion body, stable cell line generation delay.
Including the liposome during the production process provides the perfect environment for the membrane protein to settle in, hence enabling a physiology close conformation of the protein.
A large variety of target classes such as GPCRs, ion channel, membrane enzyme or porins have been already produced. For few of them, at least one level of functionality such as binding assays, patch clamp assay and enzymatic activity have been validated.
Application ranges from Antibody development, activity assay, protein vectorization into cells, protein therapy, vaccines
- Website
- synthelis.com
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