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iXCells Biotechnologies
iXCells Biotechnologies is listed as a small business research supplier in the Scientist.com network, with 2 sites in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Adipogenesis Assay Detect and quantify intracellular triglyceride accumulation in adipocytes.
- Biomarker Discovery Identify a biomarker associated with disease progression of disease, effectiveness of therapy or diagnosis of disease or condition.
- Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
- Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
- Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.
- Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Show all 16 in Biomarkers
- Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
- Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
- Human Primary Cell Isolation Isolate primary cells from various human tissues.
- Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
- Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
- Lipid Peroxidation Assay Use in vitro or in vivo assays to evaluate the effects of oxidative stress on lipid structure and function.
- Predictive Biomarkers Discovery Identify candidate biomarkers suggestive of a response to a treatment.
- Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
- TUNEL Assay Detect in situ DNA fragmentation.
- Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.
Cell Culture and Characterization
- 3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
- Adherent Cell Culture Grow monolayers of anchorage-dependent cells.
- Bacterial Cell Culture Culture and Grow bacterial cells.
- Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
- Cell Culture Culture primary or immortalized cell lines.
- Cell Line Characterization Track source history and characterize cell lines to establish identity, purity and stability.
Show all 19 in Cell Culture and Characterization
- Cell Line Construction Create new recombinant cell lines to exact specifications.
- Cell Lines Purchase culture reagents, cell lines and cellular material of any species. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have...
- Cell Sorting The purpose of cell separation is to isolate a cell population from other cells in a biological sample.
- Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.
- Gene-Edited iPSCs Disease Models Use gene-edited iPSCs to model human diseases.
- Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
- Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
- Karyotyping Evaluate the number and appearance of chromosomes in the nucleus of a eukaryotic cell.
- Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
- RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
- Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
- Stem Cell Methodologies Study Stem Cell characteristics.
- STR Profiling - Microsatellite Short Tandem Repeat Confirm cell line identity and detect cross-contamination.
Show all 121 services
Clinical Consulting
- Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Disease Models
- Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
DNA & RNA
- Amplicon - HLA Typing Use an amplicon sequencing method to identify allelic variation within the HLA genes.
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
- CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
- DNA Library Screening Screen genomic or cDNA libraries for positive clones.
- DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
Show all 14 in DNA & RNA
- DNA Synthesis Produce DNA fragments for microarrays, PCR, cloning and expression studies.
- DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.
- Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
- Genomic DNA cloning Clone and propagate genomic DNA inserts of 5-50kb.
- Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
- Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
- qPCR Analysis Measure the accumulation of PCR products in real time.
- RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
Human Biological Samples
- Biospecimen Finder Explore listings of Human Biological Samples from the suppliers on the scientist.com HBS database
- Cell Line and Cellular Services Promotion for Cells and Cell lines
- FRBESaHBS Request human biosamples including tissues, blood, serum, bone marrow, and tissue microarrays.
- HBS Healthy/Controls For requesting HBS Healthy/Controls
- HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
- HBS: Human Biological Samples - VMS Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.
Show all 25 in Human Biological Samples
- Human 3D cultures Provision of 3D culture of Human Primary Cells
- Human Blood Acquire fresh/frozen human blood based on patient demographics, disease stage, history and treatment.
- Human Blood by-products For requesting Human Blood By-products
- Human Bone Marrow Cells Acquire fresh, frozen, or fixed normal bone marrow based on patient demographics and history.
- Human Exosomes Request services related to the creation and development of human exosomes
- Human Fresh Tissue For requesting fresh human tissue
- Human Frozen Tissue For requesting frozen human tissue.
- Human Immortalized Cell Culture For requesting human cells Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely” Primary Cells are cells that have been isolated from fresh tissue (or cultures) that...
- Human iPSC's For requesting human sourced induced pluripotent stem cells.
- Human MSC's For requesting human sourced mesenchymal stem cells.
- Human Organoids Test immuno-oncology drugs and therapies on fresh, unpropagated 3D tumor organoids to evaluate efficacy and understand drug mechanism of action. Understand the intact tumor immune microenvironment, cytotoxic efficacy...
- Human Peripheral Blood Mononuclear Cells (PBMCs) Acquire fresh/frozen normal PBMCs based on patient demographics and history.
- Human Primary Cells Acquire fresh/frozen human primary cells based on patient demographics, disease stage, history and treatment. Cell Lines typically refer to legacy immortalised cells, that can be cultured and passaged “indefinitely”...
- Human Red Blood Cells Acquire fresh/frozen normal red blood cells based on patient demographics and history.
- Human T Cells Acquire T cells isolated from the human immune system.
- Human Uterus For requesting Human Uterus Samples
- Human Whole Blood Acquire fresh/frozen normal whole blood based on patient demographics and history.
- Human Whole Blood For requesting Human Whole Blood
- Human Whole Organs Procure non-transplantable whole human organs or tissues, healthy or diseased, for medical research and development.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
In Vitro Assays
- Annexin V Apoptosis Assay Detect and quantify apoptotic cells based on loss of membrane asymmetry.
- Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
- Apoptotic Cell Staining Detect apoptotic cells in culture.
- Assay Development Construct or create new assays or modify existing ones.
- Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Show all 14 in In Vitro Assays
- Cell Cycle Assays Measure cell cycle markers and the molecular events that control cell cycle progression.
- Cell Proliferation Measure cell number, cell viability and cell division.
- Glucose Release Assay Determine free glucose levels in biological samples.
- Glucose Uptake Measure glucose uptake in cultured cells using GLUT4 signaling assays.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
- In Vitro Human Cell Assays Request in vitro human cells for assays
- Luciferase Reporter Assay Evaluate promoter activity by measuring light output from the luciferase enzyme.
- Stem Cell Differentiation Microscopy Assay› Elucidate mechanisms of stem cell renewal and differentiation in vitro using fluorescence microscopy.
In Vitro Pharmacology
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- Glucose Transporter Assays Use biochemical, cell-based or in vitro assays to measure glucose transporter activity.
- Histone Deacetylase (HDAC) Assays Use biochemical, cell-based or in vivo assays to measure histone deacetylase activity.
- Immuno-oncology Assays Use biochemical, cell based or in vivo assays to measure the activity of immuno-therapy targets.
- Immuno-oncology Targets Develop drugs that take advantage of the immune system to target cancer cells.
- In Vitro Disease Models Screen pre-clinical candidates without the use of live animals.
Show all 14 in In Vitro Pharmacology
- In Vitro Excitotoxicity Models Use in vitro models to measure therapeutic endpoints associated with excitotoxic pathology.
- In Vitro Hypoxia Models Use in vitro models to measure therapeutic endpoints associated with hypoxia.
- In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
- Mitogen/Extracellular signal-regulated Kinase (MEK) Assays Use biochemical, cell based or in vivo assays to measure MEK enzyme activity.
- Target Identification Identify the target(s) of a biologically active substance.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vitro Toxicology
- ADCC and CDC Assay Services Measure toxicity of antibodies.
- Cardiomyocyte Toxicity Assess cytotoxic effects of pre-clinical compounds on cardiomyocytes.
- Cytotoxicity Test for effects on cell viability and proliferation
- Hematopoietic Cell Toxicity Examine cytotoxic effects of pre-clinical compounds or biologics on adult stem cells.
- Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
Non-Human Biospecimen
- Monkey / Non-Human Primate / NHP Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
- Mouse Cells Acquire fresh or frozen cells including but not limited to RBCs, WBCs, PBMCs, endothelial cells, T cells, fibroblasts, hepatocytes, splenocytes, etc.
Protein Sciences
- Cytokines Find recombinant cytokines or cytokine assays.
- ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
- Host Cell Protein Analysis Measure contamination of biologics with host proteins by using sequencing, chromatography and the LAL test.
- Protein Binding Determine drug-protein binding interactions
- Western Blots Detect specific proteins in a sample of tissue homogenate or extract.
Other services
- Artificial Chromosomes Clone and propagate genomic DNA inserts of 100kb or larger.
- Human Dendritic Cell (hDC) Model Test and validate the immune-modulating compounds in DC immune pathway models.
- New Request
Where it operates
Sites by country, with the cities in each.
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United States 2 sites
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Who Are We: iXCells Biotechnologies USA, LLC. is a global research and development organization specializing in a variety of patient-derived iPSC and primary cells. We provide stem cell and primary cell solutions to fit your research applications for drug discovery, toxicity testing, disease modeling, cell therapy and personalized medicine. Our scientists have deep expertise in the stem cell industry and primary cell biology with many years of experience. We will work closely with your scientists, whether in the academic, pharmaceutical or biotechnology research laboratory setting...
Show the full description
Who Are We:
iXCells Biotechnologies USA, LLC. is a global research and development organization specializing in a variety of patient-derived iPSC and primary cells. We provide stem cell and primary cell solutions to fit your research applications for drug discovery, toxicity testing, disease modeling, cell therapy and personalized medicine. Our scientists have deep expertise in the stem cell industry and primary cell biology with many years of experience. We will work closely with your scientists, whether in the academic, pharmaceutical or biotechnology research laboratory setting to customize products to your needs. iXCells is committed to providing the most affordable, reliable and high quality iPSC and primary cell related products and services with fast turnaround time.
Our Products:
Patient-derived iPS cells are valuable tools for developing therapeutic drugs and disease models. iXCells has a broad range of disease-specific iPS cell panels including neuronal diseases, cardiovascular diseases, haematological diseases and diabetes.
iXCells also offers a variety of primary cells, optimized culture media, 3D models and the related services to support your research efforts. For example, our 3D human skin equivalent construct consists of epidermal and dermal layers, which closely resembles human skin. It can be used as preliminary stage to study the penetration, resorption, metabolism and epidermal impedance of tested substances and it is widely used in many research areas including epidermal biology and wound healing.
Our Services:
Our iPSC service team consists of the industry’s leading experts, and we are proud to provide feeder-free, footprint-free iPS cells with over 90% success rate. Our iPSC services can be flexibly tailored to your needs by genetic editing, making patient-derived cells or any other collaboration.
Primary cells are ideal sources for cell-based assays because they retain the memory of their tissue of origin and reflect its state of health or disease. Therefore, we also provide a comprehensive range of highly customized cells-based assays and screening services upon human and animal primrary cells from a variety of tissues.
iXCells welcomes the opportunities to fulfilling your special requirements and energizing your discoveries. We look forward to working with you in the future.
- Website
- ixcellsbiotech.com
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