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HD Biosciences

HD Biosciences is listed as a mid sized business research supplier in the Scientist.com network, with 3 sites in 2 countries and 5 service areas.

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Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 3

Countries 2

Type of company: Mid sized business

Antibodies

Antibody Amplification Produce large amounts of antibody-based therapeutics.
Antibody based Assay Development Create specific and sensitive assays for the immunodetection of disease-specific target antigens.
Antibody Sequencing Sequence cDNA encoding variable heavy (VH) and variable light (VL) domains of a hybridoma cell line.
Biotin-Antibody Conjugation Biotinylate an antibody for improved detection.
Direct Antibody Labeling Conjugate a primary antibody to a label for direct antigen detection.
Recombinant Antibody Production Request services related to antibody production services.

Biomarkers

Biomarker Services Evaluating normal/abnormal biological conditions and characteristics within the body
Cell Migration Assays Measure chemotaxis, haptotaxis, transmigration and wound-healing.
Cell Viability Measure changes in cell number, cell division, DNA content or a cell metabolism marker such as ATP levels.
Cerebrospinal Fluid Analysis Use CSF to detect or monitor a variety of nervous system diseases or conditions.
Chemotaxis Assays Investigate the in vivo or in vitro movement of cells towards or away from a chemotactic agent.
Colony Forming Cell Assay Examine ability of hematopoietic stem cells to form colonies in vitro.

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Customized Primary Cell Isolation Plan and execute the isolation of primary cells from a specific biosample.
Cytokine Release Assay Use in vivo or in vitro assays to detect unregulated or excessive release of pro-inflammatory cytokines.
Flow Cytometry Identify fluorescently-labeled cells or physically separate cells from a larger population using biomarkers.
Fluorescent In Situ Hybridization Use FISH to identify abnormal chromosome structures and to quantify specific DNA sequences.
HCS Assay Development Requesting services related to HCS assay development.
Hematoxylin & Eosin (H&E) Staining Visualize microscopic structures in cells or tissues.
Histamine Release Assay Use in vivo or in vitro assays to measure the release of histamine in response to an allergen stimulation.
Histopathology Evaluate slide preparation of cells or tissues for abnormal features.
Human Primary Cell Isolation Isolate primary cells from various human tissues.
Immunohistochemistry Examine the toxic effects of pre-clinical compounds in small animal and patient histological samples.
Immunostaining Use labeled antibodies to detect proteins or other antigens in cells or tissues.
In Vivo Apoptosis Detection Visualize and quantify apoptosis in real time.
Interferon Gamma Release Assay Use in vivo or in vitro assays to measure the cell-mediated immune response to an infectious agent.
Lipid Kinase Assays Use biochemical, cell-based or in vivo assays to measure lipid kinase activity.
Paraffin-based Histology Perform sectioning and histological analysis of wax-embedded samples.
Propidium Iodide FACS Analysis Use DNA staining and flow cytometry to analyze the cell cycle and detect apoptosis or cell proliferation.
Single Cell Isolation Isolate single cells for subsequent single-cell analysis.
Special Stainings Use a variety of techniques for the selective visualization of specific tissue or cell types.
Stem Cell Analysis Assess hematopoietic, neural and mesenchymal cell progenitor proliferation and differentiation.
Wound Healing Assay Use cell-based assays to investigate cell proliferation, cell migration and wound closure.

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Cell Culture and Characterization

3D Cell Culture Use a scaffold-based or scaffold-free format to grow three dimensional cell and tissue structures.
Bacterial Cell Culture Culture and Grow bacterial cells.
Cell and Tissue Histology Prepare and stain frozen, fixed and embedded (FFPE) tissue samples.
Cell Culture Culture primary or immortalized cell lines.
Cell Line Construction Create new recombinant cell lines to exact specifications.
Cell Transfection Produce, package and optimize transfection of your siRNA or DNA construct.

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Cryo-based Histology Perform sectioning and histological analysis of frozen non-fixed samples.
Explant Culture Culture cells obtained from a part or parts of an in vivo structure.
Histology Examine by microscopy the anatomy of cells and tissues of clinical patients and animal models.
Induced Pluripotent Stem (iPS) Cell Reprogramming Generate induced pluripotent stem cells from adult somatic cells.
Isogenic Knockout iPSC Lines Mimic loss of function of genes associated with various diseases and disorders.
Recombinant Technology Manipulate genotypes to introduce or modify the expression of specific cell products or physical traits.
Resin-based Histology Perform sectioning and histological analysis of epoxy/acrylic/polycarbonate-embedded samples.
RNA-Based Transfection Deliver RNA to cells by microinjection, electroporation or lipid-mediated transfection.
Stem Cell Differentiation Acquire specialized cells from differentiated stem cells.
Trichrome Staining Use a variety of techniques for the selective visualization of muscle, collagen fibers, fibrin and erythrocytes.
Viral Mediated Gene Delivery Use viral carriers to introduce new genetic material into a cell.

Chemical and Compound Analysis

Natural Product Libraries Find microbial, botanical and marine sources of natural products.

Clinical Consulting

Bioanalysis Consulting Expert advice to properly and effectively discover, evaluate, and measure chemical or biological materials.
Biomarker Services Consulting Expert advice to conduct solutions for evaluating normal/abnormal biological conditions and characteristics within the body.
Cell Services Consulting Whether you are an experienced drug hunter working in the pharmaceutical industry or an academic researcher looking to submit g...
Product Testing Consulting Expert advice to evaluate the effectiveness, quality, and legitimacy of a given item or good.

Discovery Chemistry

Compound Purchase Buy compounds, building blocks or compound libraries.
Compound Purchase Consulting Buy compounds, building blocks or compound libraries.
Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
Natural Product Screening Screen large natural product collections for therapeutic activity.
Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...

Disease Models

Alzheimer's Disease Models Measure therapeutic endpoints in animal models of Alzheimer's disease.
Autoimmune Models Measure therapeutic endpoints in animal models with autoimmune disorders.
Behavioral Testing Models Investigate sensory-motor and emotional functions, social behavior and day-night activity.
Demyelination Models Measure therapeutic endpoints in animal models with demyelination pathology.
Hepatitis B Virus Models Measure therapeutic endpoints in animal models of Hepatitis B virus infection.
Hepatitis C Virus Models Measure therapeutic endpoints in animal models of Hepatitis C virus infection.

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Huntington's Disease Models Measure therapeutic endpoints in animal models of Huntington's disease.
In Vivo Technologies Models Carry out EEGs, cognition assessment, microdialysis, electrophysiology, MRI, ultrasound and tomographic analysis.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.
Liver Disease Animal Models Measure therapeutic endpoints in animal models with liver disease.
Liver Fibrosis Models Measure liver fibrosis using therapeutic endpoints such as collagen assessment, TUNEL staining and inflammatory markers.
Myelination Models Measure therapeutic endpoints in animal models with induced myelination, remyelination or developmental myelination.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Non Obese Diabetic Mice Use a single animal species to create one or more disease models for diabetes.
Obese Primates Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
Pain Model Consulting Expert advice to better evaluate and understand pain thresholds and phenomena within living organisms. Can be used to evaluate pain associated with specific diseases or injuries affecting the sensory and nervous systems.
Parkinson's Disease Models Measure therapeutic endpoints in animal models of Parkinson's disease.
Pulmonary Fibrosis Models Measure therapeutic endpoints in animal models of pulmonary fibrosis.
Schizophrenia Models Measure therapeutic endpoints in animal models of schizophrenia.
Sclerosis ALS Models Measure therapeutic endpoints in animal models of sclerosis.
Stroke Models Measure therapeutic endpoints in animal models of stroke.
Tobacco Smoke Inflammation Models Measure therapeutic endpoints in animal models of pulmonary disease.

DNA & RNA

Cloning/Subcloning Clone or Subclone nucleotide sequence or gene.
CRISPR Using advanced CRISPR technology, add or delete base pairs at a specifically targeted DNA loci.
Digital Polymerase Chain Reaction Obtain improved absolute target quantification and rare allele detection compared to conventional qPCR.
DNA Library Screening Screen genomic or cDNA libraries for positive clones.
DNA Mutagenesis Introduce insertions, deletions and substitutions into DNA clones.
DNA/RNA Extraction & Purification DNA/RNA Extraction & Purification.

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Gene/Oligo Synthesis Synthesize oligonucleotide or gene for microarrays, RT-PCR and PCR cloning.
Genome Editing Use CRISPR, ZFN, TALEN or AAV gene targeting for targeted gene mutations and creation of transgenics.
Genomic DNA Purification Isolate genomic DNA from cells or tissue samples.
Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
Oligo Synthesis Produce oligonucleotides for microarrays, RT-PCR and PCR cloning.
Plasmid DNA Preparation and Extraction Prepare plasmid DNA starting from E. coli cell pellets, transformed colonies or DNA samples.
qPCR Analysis Measure the accumulation of PCR products in real time.
Quantitative RT PCR Use quantitative reverse transcription polymerase chain reaction to measure absolute and relative mRNA abundance.
RNA Extraction Isolate total RNA or mRNA from cells or tissues
RNA Interference Use small sequences of RNA that correspond to the targeted gene product to inhibit mRNA translation.
RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
siRNA Synthesis Produce high quality siRNAs for gene silencing studies.
Target Gene Expression Measure expression of a target gene at the protein, RNA and DNA level.
Whole Genome Amplification (WGA) Amplify an entire genome from a single cell.

Drug Development

Assay Development Consulting Request consultant services measuring the activity of a drug or biochemical in an organism or organic sample.
Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.

Human Biological Samples

HBS: Human Biological Samples Request human biosamples including tissues, blood, serum, bone marrow, tissue microarrays, etc.

In Vitro ADME

Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
HT ADME (High-Throughput Absorption, Distribution, Metabolism and Excretion) Analyze the process and effects of a chemical that is ingested by an organism using an advanced technological screening process. Use for drug...
Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
Multidrug Resistance Identify potential causes of drug-drug interactions.
Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.

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Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.

In Vitro Assays

Antivirals Measure anti-viral activity in biochemical and cell assays.
Apoptosis Assays Detect apoptotic events that lead to programmed cell death.
Assay Development Construct or create new assays or modify existing ones.
Caspase Assay Detect early to mid stage apoptosis or differentiate apoptosis from necrosis.
Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.

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Cell Proliferation Measure cell number, cell viability and cell division.
Cytometric Bead Array (CBA) FACS Analysis Use flow cytometry and antibody-coated beads to simultaneously detect multiple target proteins.

In Vitro Pharmacology

Calcium Channel Assays Use biochemical, cell-based or in vivo assays to measure calcium channel activity.
Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
Polymerase Assays Measure polymerase activity in biochemical and cell-based assays.

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Selectivity Profiling Determine the specificity of a ligand for its target by testing it against a large panel of related target proteins.
Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vitro Toxicology

ADCC and CDC Assay Services Measure toxicity of antibodies.
Cardiotoxicity Evaluate the effect of a compound on heart electrophysiology and muscle function.
Cytotoxicity Test for effects on cell viability and proliferation
Genotoxicity Evaluate potential of a compound to cause mutations and chromosomal aberations
Hepatocyte Toxicity Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
hERG Inhibition Measure the arrhythmia-producing potential of test compounds.

In Vivo ADME

Mass Balance Study - Dog / Canine Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in dogs/canines.
Mass Balance Study - Other Species Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in other species.
Mass Balance Study - Rat Conduct a study to investigate the plasma pharmacokinetics and excretion of your compound as well as total radioactivity in rats.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
In Vivo PK Consulting Expert advice on pharmacokinetics and how specific drugs affect the body to determine function, effectiveness, dosage size, etc…

Model Development

Knockin Mice Make targeted insertion of a gene of interest into a specific gene locus to create transgenic mice.
Non-Human Primate Models Use a single animal species to create one or more disease models.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Non-Human Biospecimen

Mouse Tissues Acquire fresh or frozen tissues including but not limited to those from the central nervous system, endocrine system, gastrointestinal system, integumentary system, reproductive system, lymphatic system, etc.

Product Orders

Kits and Reagents Submit a request to multiple vendors for kits and reagents.

Protein Sciences

ELISA Detect the presence of antigens recognized by antibodies or find antibodies that recognize an antigen.
Enzymology Enzymology studies the biochemical activity, structure, and function of enzymes. Two key area of Enzymology are Cytochrome P450...
Protein Binding Determine drug-protein binding interactions
Protein Services Consulting Expert advice to evaluate and analyze protein function and expression.
Virus Production Produce high titer viruses, viral expression vectors and vaccines.

REACH Services

OECD 471: Bacterial Reverse Mutation Test (Ames) Measure the mutagenic potential of test compounds.
OECD 474: Mammalian Erythrocyte Micronucleus Test The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone...

Other services

Human Dendritic Cell (hDC) Model Test and validate the immune-modulating compounds in DC immune pathway models.
New Request  
proxy-CRISPR Gain access to previously unreachable areas of the genome via proxy-CRISPR, a proximal CRISPR targeting method that restores FnCas9 nuclease activity.
Uterotrophic Bioassay in Rodents Evaluate the ability of a chemical to elicit biological activities consistent with agonists or antagonists of natural estrogens.

Service areas:

Biology Chemistry DMPK Pharmacology Toxicology

United States New Jersey, San Diego 2 sites
China Shanghai 1 site

Show the full description

HD Biosciences Co. Ltd. (HDB) is a leading biology focused preclinical drug discovery contract research organization located in Zhangjiang high-tech park in Shanghai. The company offers comprehensive technology platforms and expertise around target discovery, hit-to-lead, lead generation and optimization and candidate selection in preclinical drug discovery and development for both small molecules and biologics. Our services include biology assay development, compound profiling, high throughput screening, DMPK, toxicology, in vivo pharmacology, drug efficacy and safety assessment, as well as natural product based lead compound discovery. In early last year, HDB introduced medicinal chemistry program to support SAR focused research capability, and therefore advanced biology-focused services toward more comprehensive and integrated preclinical R&D services.

HDB has provided extensive and high quality services to multinational large pharmaceutical companies, including Pfizer, Lilly, Merck, GSK, as well to many other pharmaceutical and biotech companies around the world. The outstanding track records of services and the capability to provide inputs and expertise in the projects have helped the company earn great reputation in the industry.

In Oct 2011, HDB received 2011 Deloitte Technology Fast 50 China 2011 award. Based on the percentage of revenue growth in straight three years, HDB was ranked No.12 in the list as one of the fastest growing technology company in China.

Website: www.hdbiosciences.com

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