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Piramal Pharma Solutions
Piramal Pharma Solutions is listed as a large business research supplier in the Scientist.com network, with 13 sites in 4 countries and 3 service areas.
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Sites
13
Countries
4
Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Large business
Agricultural Sciences Research & Development
- Agrochemical Analytical Method Development Engineer sensitive and selective methods that meet GLP validation requirements to assess different agrochemical properties.
- General Agrochemical Compound Library Find potential compound candidates for agrochemical or agro-product research and development.
Antibodies
- Antibody-Drug Conjugation Improve therapeutic properties of an antibody or drug by joining them together.
Chemical and Compound Analysis
- Analytical Separations and Purification Analytical Separation and Purification of compound/molecule.
- Chemical Stability Measure the stability of small molecules in solution.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- Elemental Impurity Analysis Identify and evaluate the presence of heavy metals in pharmaceuticals.
- Excipient Compatibility Test excipients for drug formulation, effects of temperature, time, humidity, pH and light exposure as well as excipient release.
- Non GLP Small Molecule Bioanalysis Detect and analyze the pharmacokinetic profile of small molecules.
Show all 10 in Chemical and Compound Analysis
- Particle Size Analysis Measure particle size distribution and characterize particle size, porosity and composition.
- Partition Coefficient Determine lipophilicity (hydrophobicity) of compounds by measuring log P.
- Solubility Studies Analyze substances for kinetics of solubility using nephelometry and UV-Vis spectrometry.
- Viscosity Testing Evaluate the fluid flow properties of liquids for product evaluation and quality control.
Chemistry, Manufacturing and Controls (CMC)
- Bulk Manufacturing Find facilities for large-scale mass production.
- Chemistry Manufacturing Controls Access contract manufacturing and regulatory guidance in setting specifications and drug dosage formulations.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
- Drug Formulation Combine substances including the active drug into a final product with the desired metabolic and therapeutic properties.
- Drug Product Stability Use accelerated stress conditions to determine degradation pathways and identify manufacturing issues.
- Excipients Acquire synthetic or natural inert components to formulate therapeutic agents.
Show all 12 in Chemistry, Manufacturing and Controls (CMC)
- Filtration Sterilization Sterilize thermolabile solutions using filtration technologies.
- GMP Synthesis Synthesize APIs including small molecules, formulations and protein-based drugs under GMP compliance.
- Polymorph Screening Screen for unwanted API forms resulting from the drug formulation process.
- Salt Form Selection Use high-throughput automated arrays to combine APIs with multiple salts and ions to optimize formulation.
- Tablet Manufacturing Use automatic or semi-automatic machinery to create various standard and non-standard tablets.
- Thermal Analysis Characterize compounds based on calorimetry and thermodynamic data.
Show all 77 services
Discovery Chemistry
- Bioanalytical Lab Services Bioanalytical Lab Services
- Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- Impurity Synthesis Use high resolution MS or NMR to eliminate intermediates or organic byproducts and determine impurity content.
Show all 12 in Discovery Chemistry
- Large Scale Purification Purify gram to kilogram amounts of recombinantly-expressed or wild-type proteins.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
- Method Development and Validation Develop and validate methods for synthesis and scale up of drug candidates.
- Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
- Trace Elemental Analysis Identify organic and inorganic elements in foods and dietary supplements at ppm to sub-ppt levels.
In Vitro ADME
- Blood Brain Barrier Measure movement of drugs from circulating blood to brain extracellular fluid.
- Caco-2 Cell Permeability Measure passive diffusion of drugs across Caco2 cell monolayers.
- Compound Distribution Determine the metabolic fate of a drug candidate in tissue and organs of diseased and normal animal models.
- Conjugate Detection Measure the conjugation of endogenous small molecules to drug candidates after in vivo administration.
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
Show all 21 in In Vitro ADME
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Drug Distribution Studies Determine the metabolic fate of compounds within tissues, organs and plasma.
- Drug Drug Interactions Determine whether a substance affects the activity of a drug when both are administered together.
- GI Fluid Stability Determine dosing and turnover of drug candidates in gastrointestinal fluids.
- In Vitro ADME in Vitro ADME services
- Intestinal Permeability Use Caco 2 and MCDK cells to assess mono-directional drug transport by passive diffusion in culture.
- Membrane Transporters Use Caco 2 cells to assess bi-directional drug transport in the presence or absence of P-glycoprotein (P-gp) inhibitors.
- Metabolic Stability Measure metabolic vulnerability to drug metabolizing enzymes using cell-free, cell-based and in vivo assays.
- Metabolic Stability in Hepatocytes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver cells.
- Metabolic Stability in Microsomes Assess the susceptibility of drugs to metabolism by Phase I (CYP450) and Phase II enzymes in liver microsomes.
- Metabolite Generation Analyze the formation of drug metabolites after administration of drug to an animal model or patient.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Metabolite Synthesis Synthesize drug metabolites that are formed after administration of drug to an animal model or patient.
- Plasma Stability Assay Determine degradation rate of drug candidates in plasma.
- Red Blood Cell (RBC) Partitioning (Blood/Plasma Ratio) Measure the distribution of a compound between red blood cells and plasma.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
- Cell Based Assays Consulting Expert advice to evaluate the functions of specific chemicals based on their constructions and systems.
- Cell Proliferation Measure cell number, cell viability and cell division.
- In Vitro Assay Development Develop innovative assay and screening methods outside a living organism to enable a wide range of pre-clinical activities.
- In Vitro Efficacy Test Use in vitro models to test the efficacy of your products.
In Vitro Toxicology
- Cytotoxicity Test for effects on cell viability and proliferation
In Vivo ADME
- Absorption studies Study the factors determning how efficiently a compound may enter the bloodstream.
In Vivo Pharmacokinetics
- Maximum Tolerated Dose (MTD) Studies Determine Maximum Tolerated Dose (MTD) of a drug candidate in either a single or repetitive dosing study in a rodent (typically mouse or rat).
- Pharmacokinetic (PK) Screening Measure the absorption, distribution, metabolism and excretion of a compound.
- Pharmacokinetic (PK) Screening - Dog / Canine Run pharmacokinetic studies in dogs that measure a drug’s absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Minipig Run pharmacokinetic studies in minipigs that measure a drug’s absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Mouse Run pharmacokinetic studies in mice that measure a drug's absorption, distribution, metabolism and excretion.
- Pharmacokinetic (PK) Screening - Rat Run pharmacokinetic studies in rats that measure a drug's absorption, distribution, metabolism and excretion.
Show all 8 in In Vivo Pharmacokinetics
- Repetitive Maximum Tolerated Dose (MTD) Mouse Study Use mouse models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
- Repetitive Maximum Tolerated Dose (MTD) Rat Study Use rat models to determine the MTD of a drug candidate by repetitive administrations for 7 days.
Protein Sciences
- Protein Binding Determine drug-protein binding interactions
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- New Request
Service areas:
Biology
Chemistry
DMPK
Where it operates
Sites by country, with the cities in each.
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India 7 sites
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United States 3 sites
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United Kingdom 2 sites
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Canada 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Piramal Discovery Solutions (Formerly Oxygen Healthcare) provide a world class integrated discovery services platform from its state-of-the-art research centre in India. One of the newer members of the Piramal Healthcare family, PDS’s delivery model has a proven track record of providing a step change in the effectiveness of drug discovery for a range of global pharmaceuticals and biotechnology companies operating at the forefront of drug discovery. We provide services in: Organic and Medicinal Chemistry - chiral, nucleoside, coefficients, peptide In Vivo Assays - arthritis, colitis...
Show the full description
Piramal Discovery Solutions (Formerly Oxygen Healthcare) provide a world class integrated discovery services platform from its state-of-the-art research centre in India. One of the newer members of the Piramal Healthcare family, PDS’s delivery model has a proven track record of providing a step change in the effectiveness of drug discovery for a range of global pharmaceuticals and biotechnology companies operating at the forefront of drug discovery.
We provide services in:
- Organic and Medicinal Chemistry - chiral, nucleoside, coefficients, peptide
- In Vivo Assays - arthritis, colitis, psoriasis, obesity
- In Vitro Assays - ADME, cell-based, kinase, GPCR
- Website
- www.piramal.com/pharmasolutions
Supplier diversity
SAM.gov small-business designations
Minority-owned
US small-business federal-contractor designation, self-certified in the U.S. federal System for Award Management (SAM.gov). Coverage is limited to matched U.S. small-business suppliers, so an absent designation is not evidence of its absence.
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