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biomodal
biomodal is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Small business
Biomarkers
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Data Science/Bioinformatics
- In Silico Cancer Genomics/Cancer Transcriptomics Analysis Interpret DNA sequencing and microarray data for cancer studies.
DNA & RNA
- Cell Free DNA Assay Detect known mutations and discover new ones in cell-free plasma DNA.
- DNA Hydroxy Methylation Seq Use epigenetic services to analyze genome-wide DNA hydroxymethylation.
- Genotyping Examine a DNA sequence to identify specific genetic varients .
- Methylation Analysis Determine genomic methylation patterns and analyze methylation in tumors and treated samples.
- Methylation Specific PCR Determine the methylation status of a CpG site without the need for base-specific endonucleases.
- NGS: Next Generation Sequencing Sequence millions of template DNA molecules in parallel.
Show all 13 in DNA & RNA
- Non-Bisulfite DNA Methylation Analysis Analyze DNA methylation by methods such as differential enzymatic cleavage or affinity capture
- RNA Profiling Quantify the expression levels of mRNA transcripts, enabling the determination of gene expression patterns.
- Sequence Based Methylation Analysis Detect DNA methylation sites within cytosine-phosphate-guanine (CpG) dinucleotides at single base-pair resolution.
- SNP Characterization Identify single nucleotide polymorphisms to make genetic associations, analyze disease SNPs and determine LOH.
- Total RNA Sequencing Identify novel RNA transcripts and detect gene expression changes.
- Whole Genome Profiling Develop sequence-based physical maps for the assembly of genomes.
- Whole Genome Sequencing Determine the entire genetic make-up of an organism.
Human Biological Samples
- Liquid Biopsy Test and detect either circulating tumor cell-associated biomarkers or circulating tumor DNA.
Scientific Data Services
- Bioinformatics Bioinformatics is a powerful method of storing, retrieving and analyzing biological data.
- Epigenomics Data Analysis Quantify and analyze DNA methylation and/or DNA binding protein data sets.
- NGS: Next Generation Sequencing Data Analysis Use software to interpret data created by RNA-Seq, DNA-Seq, ChIP-Seq and DNA methylation experiments.
Show all 20 services
Other services
- New Request
Where it operates
Sites by country, with the cities in each.
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United Kingdom 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Cambridge Epigenetix (CEGX) is a biosciences company that aims to be the world leading provider of high quality, easy to use epigenetic tools. Our starting point is TrueMethyl™ oxidative bisulfite sequencing (oxBS-Seq), a novel technology that pioneers quantitative, single-base resolution sequencing of the modified bases hydroxymethyl cytosine (5hmC) and methylcytosine (5mC). TrueMethyl enables analysis of the DNA methylome with unprecedented accuracy and opens new avenues for basic research, pharmaceutical discovery and diagnostics. Recent studies have shown that at some sites...
Show the full description
Cambridge Epigenetix (CEGX) is a biosciences company that aims to be the world leading provider of high quality, easy to use epigenetic tools.
Our starting point is TrueMethyl™ oxidative bisulfite sequencing (oxBS-Seq), a novel technology that pioneers quantitative, single-base resolution sequencing of the modified bases hydroxymethyl cytosine (5hmC) and methylcytosine (5mC). TrueMethyl enables analysis of the DNA methylome with unprecedented accuracy and opens new avenues for basic research, pharmaceutical discovery and diagnostics.
Recent studies have shown that at some sites in the genome the level of 5hmC can be comparable to the level of 5-mC, emphasizing the importance of identifying these variants accurately. However, traditional bisulfite sequencing cannot discriminate between 5hmC and 5mC.
Co-invented by Prof. Shankar Balasubramanian, who previously co-invented the Solexa / Illumina sequencing-by-synthesis platform, and Michael Booth, innovative oxBS-Seq technology utilises a selective chemical oxidation that accurately distinguishes between 5-mC and 5-hmC.
TrueMethyl can be used with a variety of common platforms including next generation sequencing systems, methylation arrays, and targeted assays. Employing chemical oxidation gives very high conversion efficiencies and minimises sequence context effects, giving results of unparalleled quality.
TrueMethyl enables:
- Quantitative measurement of 5hmC and 5mC in parallel
- Single-base resolution methylation and hydroxymethylation analysis
- Confirmation of the location of unmethylated cytosines
CEGX is funded by Syncona Partners as well as Cambridge Enterprise and our management team comprises industry leaders and epigenetics expertise.
- Website
- www.biomodal.com
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