Supplier site
Group of sites (click to zoom)

Scientist.com supplier network (site locations)

Research supplier

Ophthy-DS

Ophthy-DS is listed as a small business research supplier in the Scientist.com network, with 1 site in 1 country and 1 service area.

View Ophthy-DS on Scientist.com

Email me this page as a PDF

Search companies, drugs, suppliers and investigators, and follow each one to the others. Individual plan, $249/seat/mo. Card required.

Sites 1

Countries 1

Type of company: Small business

Commercial Consulting

Portfolio Management Manage a portfolio of projects in early-stage drug discovery and provide factors that determine the success of the proposed portfolio.

Disease Models

Cataract Models Measure therapeutic endpoints in animal models of cataracts.
Cognition Models Measure therapeutic endpoints in animal models of cognition.
Comparative Pharmacology Compare drug responses across species for improved reliability in translational studies.
Diabetic Retinopathy Models Assess therapeutic efficacy of drug candidates in diabetic retinopathy models of disease.
Dry Eye Models Measure therapeutic endpoints such as tear induction, TBUT, Schirmer strips (tear volume) and cornea staining.
Infectious Disease Models Test therapeutic efficacy of drug candidate in infectious disease model.

Show all 17 in Disease Models 11 more

Inflammation Models Measure therapeutic endpoints in animal models for inflammation.
Macular Degeneration Models Use a single animal species to create one or more models for eye disease.
Morris Water Maze Investigate spatial learning and memory in rodents.
Neuroscience Models Test therapeutic efficacy of drug candidate in neurological disease model.
Object Recognition Measure spatial navigation, working memory and cognitive function in animal models.
Ocular Inflammation Models Measure ocular inflammation in models of eye disorders such as uveitis and keratitis.
Ophthalmic Models Test drug candidates in glaucoma, macular degeneration, keratitis, uveitis and CMV retinitis models.
Optogenetics (rodent behavioral testing) Use light to selectively control the molecular events in cells of living organisms.
Pigmented Rabbit Use a single animal species to create one or more disease models for eye cancer.
Receptor Binding Models Measure the binding and distribution of drugs and biologics in animal tissues.
Wound Healing Models Measure therapeutic endpoints in animal models of wound healing.

Drug Development

Safety Pharmacology Consulting Consulting services that help with the detection of potential undesirable pharmacodynamic effects of chemical entities on physiological functions.
Small Molecule Drug Development Consulting Request consulting services related to small molecule development.
Target Validation Consulting Help to demonstrate that modification of target activity has potential therapeutic benefits.

General in vivo Toxicology

Dose Range Finding Study - Other Species Conduct a study to determine the dose range of your compound in other species.
Dose Range Finding Study - Rat Conduct a study to determine the dose range of your compound in rats.
Repeat Dose Toxicity Study - Rat Conduct a repeat dose study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Show all 65 services 52 more

In Vitro Pharmacology

Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
In Vitro Diabetes Models Measure insulin stimulation of glucose uptake and metabolism of lipids including cholesterol and triglycerides.
In Vitro Eye Models Measure cytokine production, cell viability, apoptosis and wound healing.
In Vitro Neural Models Use cultured neurons, neuronal progenitor cells and stem cell differentiation to create cellular models of neurological disease.
In Vitro Oncology Models Use cell-based and biochemical models of cancer.
Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.

Show all 7 in In Vitro Pharmacology 1 more

Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.

In Vivo Pharmacokinetics

In Vivo Pharmacokinetics Run pharmacokinetic studies in animals that measure a drug's absorption, distribution, metabolism and excretion (ADME).
Ocular Pharmacokinetic (PK) Screening - Dog / Canine Conduct a pharmacokinetic screening study in dogs/canines that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Other Species Conduct a pharmacokinetic screening study in other species that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rabbit Conduct a pharmacokinetic screening study in rabbits that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.
Ocular Pharmacokinetic (PK) Screening - Rat Conduct a pharmacokinetic screening study in rats that measures the absorption, distribution, metabolism and excretion of your compound following ocular administration.

Model Development

Animal Model Development Create new systems for profiling pre-clinical therapeutics, devices, and surgical techniques.
Knockout Mice Create transgenic mice that are genetically engineered to inactivate a gene or set of genes.
Lewis Rat Use a single animal species to create one or more disease models for metastatic cancer, hematopoiesis and anemia.
Standard Models Create new animal disease models or modify existing models to study specific diseases, side-effects or symptoms.
Surgical Models Create new animal models using techniques such as vascular catherization, soft tissue procedures or device implants.
Transgenic Models Create animal models engineered for use in a specific therapeutic area.

Other Specialty Toxicology

Ocular Phototoxicity Study - Other Species Conduct a study to determine the extent to which your compound is capable of producing phototoxic side effects in ocular tissues of other species.
Ocular Phototoxicty Study - Rat Conduct a study to determine the extent to which your compound is capable of producing phototoxic side effects in ocular tissues of rats.

Safety Pharmacology

CNS Behavioral Measure safety toxicology effects of CNS and behavioral drugs.
Drug Discrimination Study - Rat Conduct a study to investigate the length of psychoactive effects of your compound in rats and conduct dose range finding for further studies.
Repeat Dose Neurotoxicity Study - Other Species Conduct a repeat dose study in other species to determine the neurotoxicity of your compound.
Repeat Dose Neurotoxicity Study - Rat Conduct a repeat dose study in rats to determine the neurotoxicity of your compound.
Safety Pharmacology Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Target Safety Assessment Understand the role of your drug target and assess risks in normal physiology.

Specialty Dosing Routes

Intravitreal Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct an intravitreal ocular toxicity study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Minipig Conduct an intravitreal ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct an intravitreal ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Other Species Conduct an intravitreal ocular toxicity study in other species to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Rabbit, Non-pigmented (New Zealand White; NZW) Conduct an intravitreal ocular toxicity study in non-pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Intravitreal Toxicity and/or Toxicokinetic Study - Rabbit, Pigmented (Dutch Belted, New Zealand Red) Conduct an intravitreal ocular toxicity study in pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.

Show all 13 in Specialty Dosing Routes 7 more

Ophthalmologic Toxicology Measure toxicity by microscopy, vitrectomy, tonometry, electroretionography and corneal colorimetry.
Topical Ocular Toxicity and/or Toxicokinetic Study - Dog / Canine Conduct a topical ocular toxicity study in dogs/canines to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Minipig Conduct a topical ocular toxicity study in minipigs to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Monkey / Non-human Primate Conduct a topical ocular toxicity study in monkeys/non-human primates to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Non-pigmented (New Zealand White; NZW) Conduct a topical ocular toxicity study in non-pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rabbit, Pigmented (Dutch Belted, New Zealand Red) Conduct a topical ocular toxicity study in pigmented rabbits to determine the toxicity and toxicokinetic behavior of your compound.
Topical Ocular Toxicity and/or Toxicokinetic Study - Rat Conduct a topical ocular toxicity study in rats to determine the toxicity and toxicokinetic behavior of your compound.

Testing Services

In Vitro Skin Models Measure skin model penetration and invasion, photosensitivity and toxicity.

Other services

New Request

Service areas:

Pharmacology

United States Kalamazoo 1 site

Ophthy-DS offers discovery services for ophthalmic drug discovery. non-GLP safety studies Blue Light damage: rat and mouse VEGF induced leakage: rabbit Laser induced CNV: Rat and mouse: rabbit coming soon Uveitis: Rabbit Retinal detachment: Rat and rabbit Dry Eye (desiccating stress chamber with or without scopolamine): Mouse and Rat NaIO3: Rat and Rabbit Corneal neovascularization Corneal epithelium injury/scrape We have also run many genetic RD models for clients but do not have any standing colonies. Rat: RCS, P23H, S323 Mouse: A2E KO, MCP-1 KO, APOE knock in and some non-published...

Show the full description

Ophthy-DS offers discovery services for ophthalmic drug discovery.

non-GLP safety studies
Blue Light damage: rat and mouse
VEGF induced leakage: rabbit
Laser induced CNV: Rat and mouse: rabbit coming soon
Uveitis: Rabbit
Retinal detachment: Rat and rabbit
Dry Eye (desiccating stress chamber with or without scopolamine): Mouse and Rat
NaIO3: Rat and Rabbit
Corneal neovascularization
Corneal epithelium injury/scrape

We have also run many genetic RD models for clients but do not have any standing colonies.
Rat: RCS, P23H, S323
Mouse: A2E KO, MCP-1 KO, APOE knock in and some non-published models

We also establish models for clients where they pay for the development costs and we only run the model for them.

We have extensive experience in various dosing procedures including IVT, sub tenon, and intra cameral in mouse, rat, and many larger species.

We have over 15 years’ experience doing ERGs (Diagnosys: Espion) and ocular imaging (Heidelberg HRA+OCT) and can also offer standard exams such as slit lamp, indirect, draize scoring and IOP measurements.

Ophthy-DS partners internally with PharmOptima an ADME company which specializes in Ocular tissues dissection for Ocular PK work and in vivo assays.

Ophthy-DS also works closely with MPI Research, a full service toxicology company nearby, to offer IND enabling toxicology services.

Website: www.ophthy-ds.com

Work with Ophthy-DS on Scientist.com

For prices, more details, or to contact Ophthy-DS, visit Scientist.com.

View on Scientist.com