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Viva Biotech
Viva Biotech is listed as a mid sized business research supplier in the Scientist.com network, with 4 sites in 2 countries and 4 service areas.
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Services
What this research supplier says it provides, as listed in the Scientist.com network.
Type of company: Mid sized business
Antibodies
- Antibody Purification Purify multiple antibody types including IgG, IgM, IgA and IgY.
- Antibody Reagents Request information or a price quote for Antibody Reagents services
Biomarkers
- Epigenetics Epigenetics sits at the cutting edge of drug discovery. The ability to modify genomes without changing any sequences with methylation.
Cell Culture and Characterization
- cGMP Cell Banking Request information or a price quote for cGMP Cell Banking services
Chemical and Compound Analysis
- Chemical Stability Measure the stability of small molecules in solution.
- Chiral Separation Purify therapeutically active isomers of drug candidates.
- NMR Methods Use nuclear magnetic resonance spectroscopy to identify drug intermediates.
- NMR Structure Determine molecular structure, identify chemical impurities and validate sample integrity.
- Optical Rotation Distinguish between optical isomers as well as between natural versus man-made compounds.
- Sample Bioanalysis Determination of concentration of an analyte in biological sample.
Show all 8 in Chemical and Compound Analysis
- Small Angle X-Ray Scattering Obtain low-resolution structures of biopolymers in solution using an x-ray beam.
- Structural Chemistry Examine the relationship between protein structure and function.
Chemistry, Manufacturing and Controls (CMC)
- Advanced intermediates Sourcing advanced intermediates
- API and Drug Product Stability Testing API and Drug Product Stability Testing.
- Chemistry, Manufacturing and Controls (CMC) Request Chemistry, Manufacturing and Controls services
Show all 88 services
Discovery Chemistry
- Building Blocks Find chemicals used for creating new compound chemotypes and HTS libraries.
- Compound Docking Identify potential compound hits based on the 3D structure of a target protein.
- Compound Management Buy, maintain and process compound libraries, natural product libraries and building blocks.
- Compound Synthesis Synthesize small molecule candidates for use in hit followup, lead optimization and medicinal chemistry.
- Custom Building Blocks Find or synthesize mg to kg amounts of chemical building blocks, scaffolds and reactive intermediates.
- Discovery Computational Chemistry Model the interaction of a drug candidate with protein targets such as kinases, GPCRs, receptors, ion channels or enzymes.
Show all 18 in Discovery Chemistry
- DNA Encoded Library (DEL) capabilities The rapid screening of vast chemical libraries by encoding millions of small molecules with unique DNA sequences, facilitating the identification of potential drug candidates.
- Hit to Lead (H2L) Evaluate, perform limited optimization and identify small molecule hits from high throughput screens.
- HTS Libraries Find targeted and broad collections of chemical compounds for high throughput screening and ADMET applications.
- Lead Optimization Perform chemical structural changes to improve preclinical drug candidate.
- Library Design & Evaluation Use structural knowledge to design target-focused compound libraries for screening.
- Pharmacophore Modeling Use computer models to identify hits based on structural similarity to known active compounds.
- QSAR Analysis Develop quantitative structure–activity relationship models for drug design.
- Stable Isotope Synthesis Label drug candidates with stable isotopes that simplify compound tracking and distribution studies.
- Structure Activity Relationship (SAR) Analyze the relationship between the structure of a compound and its biological activity.
- Structure Property Relationship (SPR) Determine the functionality of a compound through the analysis of it's structure.
- Transporters Selectively screen for compounds with good permeability in the intestine, skin, or blood-brain barrier using drug transporter a...
- Virtual Screening Use software algorithms to virtually screen millions of potential compounds and peptides for binding.
Disease Models
- General Pain Models Measure therapeutic endpoints in animal models of general pain.
- Inflammatory Pain Models Measure therapeutic endpoints in animal models of inflammatory pain.
- Obese Mice Use a single animal species to create one or more disease models for diet-induced obesity and type II diabetes.
- Pain Models Test therapeutic efficacy of drug candidate in pain model.
- Visceral Pain Models Measure therapeutic endpoints in animal models of visceral pain.
DNA & RNA
- cDNA cloning & subcloning Move cDNA fragments between different cloning vectors.
- DNA Reagents Request information or a price quote for DNA Reagents services
- RNA Reagents Request information or a price quote for RNA Reagents services
Drug Development
- Chemistry, Manufacturing and Controls (CMC) Consulting Consultant services related to the development of pharmaceutical and biopharmaceutical drug products that are consistently effective, safe and high quality for consumers.
- Medicinal Chemistry Consulting Apply chemistry training to the process of synthesizing new pharmaceuticals.
In Vitro ADME
- CYP Induction Detect increases in the expression of various isoforms of cytochrome P450 (CYP450).
- CYP Inhibition Assay Assess the inactivation and inhibition of cytochrome P450 (CYP450) in microsomes isolated from primary human hepatocytes or liver.
- Cytochrome P450s Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
- Isotopic Labeling Track labeled isotopes through a metabolic pathway or cell by measuring mass, vibrational mode or radioactive decay.
- Metabolite Identification Identify drug metabolites that are formed after administration of drug to an animal model or patient.
- Phase I Metabolism Use enzymes such as cytochrome P450 oxidases to introduce reactive or polar groups into xenobiotics.
Show all 7 in In Vitro ADME
- Phase II Metabolism Use transferase enzymes such as glutathione S-transferases to conjugate phase I xenobiotics to polar compounds.
In Vitro Assays
- Assay Development Construct or create new assays or modify existing ones.
- Cell Based Assays Apply compounds to cells and test for cellular phenotypes and effects on gene expression
In Vitro Pharmacology
- Drug Target Assays Gain insight into the selectivity and mode-of-action of a compound's pharmacological targets.
- G-Protein Coupled Receptor (GPCR) Assays Detect ligand binding, receptor dimerization and downstream signal transduction events.
- High Throughput Screening Conduct millions of chemical, genetic or pharmacological tests in a short period of time.
- In Vitro Oncology Models Use cell-based and biochemical models of cancer.
- Ion Channels Use fluorometry, electrophysiology and radiometric binding assays to measure ion channel activity.
- Kinase Assays Measure activity of over 500 kinases in biochemical or cell-based assays.
Show all 11 in In Vitro Pharmacology
- Nuclear Receptor Assays Measure nuclear receptor activity in biochemical and cell assays.
- Protein Targets Protein Targets are of pharmaceutical interest for drug discovery purposes.
- Protein/Enzyme Targets For requesting Protein/Enzyme Targets
- Target Characterization Characterize potential drug targets during the drug discovery process.
- Target Validation Demonstrate that modification of target activity has potential therapeutic benefits.
In Vivo Pharmacokinetics
- Pharmacokinetic (PK) Screening - Other Species Run pharmacokinetic studies in large animals that measure a drug's absorption, distribution, metabolism and excretion.
Product Orders
- Kits and Reagents Submit a request to multiple vendors for kits and reagents.
Protein Sciences
- Bacterial Expression Produce milligram, gram and kilogram amounts of proteins.
- Fluorophore Protein Conjugation Attach a fluorescent probe to a protein.
- Fusion Proteins Use recombinant DNA technology to create and express proteins derived from more than one gene.
- Insect Expression Use baculovirus infected cells or non-lytic cell systems to produce glycosylated proteins.
- Large Scale Protein Production Produce large amounts of protein using fermentors, wave mixers, bioreactors, and large-scale purification workflows.
- Mammalian Expression Express high yields of recombinant proteins, antibodies, virus, viral-subunit proteins and gene-therapy vectors.
Show all 21 in Protein Sciences
- Native Protein Purification Purify native proteins from sources such as tissue & serum.
- Peptide Synthesis Synthesize custom peptides that are long, have unusual modifications or are cyclic.
- Phage Display Use in vitro screening method to identify protein binding partners.
- Protein Binding Determine drug-protein binding interactions
- Protein Conjugation Create tagged monoclonals, polyclonal and recombinant proteins.
- Protein Expression Produce recombinant proteins in prokaryotic or eukaryotic systems.
- Protein Production Produce recombinant protein molecules in prokaryotic or eukaryotic systems.
- Protein Products Find native and recombinant proteins and peptides.
- Protein Purification Isolate native or recombinant proteins from a sample.
- Protein Reagents Request information or a price quote for Protein Reagents services
- Recombinant Proteins Use recombinant DNA to produce proteins in vivo or in vitro.
- Solid Phase Peptide Synthesis Create peptides on solid supports with reduced product loss.
- Surface Plasmon Resonance (SPR) Measure interactions of biomolecules including antibodies, vaccines, biomarkers and small molecules.
- Virus Production Produce high titer viruses, viral expression vectors and vaccines.
- Yeast Expression Amplify eukaryotic proteins that contain post translational modifications.
Testing Services
- Membrane Permeability (PAMPA) Parallel Artificial Membrane Permeability Assay (PAMPA) - Measure passive diffusion of drugs by the parallel artificial membrane permeation assay.
Other services
- New Request
Service areas:
Where it operates
Sites by country, with the cities in each.
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China 3 sites
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United States 1 site
About this supplier
In the supplier's own words, as listed in the Scientist.com network.
Based in Shanghai, China Viva Biotech is one of the few biology-focused CROs providing preclinical drug discovery research services. Viva is privately owned and financed by leading investors in the US. It currently employs close to 200 scientists at a 65,000 sq. ft. research center. The center is equipped with state-of-the-art instruments housed by modern laboratories in an artistically designed building. Viva now works with all of the top ten largest global pharmaceutical companies and dozens of small to medium sized US and Europe-based businesses in studies of gene-to-structure, in vitro...
Show the full description
Based in Shanghai, China Viva Biotech is one of the few biology-focused CROs providing preclinical drug discovery research services.
Viva is privately owned and financed by leading investors in the US. It currently employs close to 200 scientists at a 65,000 sq. ft. research center. The center is equipped with state-of-the-art instruments housed by modern laboratories in an artistically designed building. Viva now works with all of the top ten largest global pharmaceutical companies and dozens of small to medium sized US and Europe-based businesses in studies of gene-to-structure, in vitro and in vivo assays, target ID, ADME, animal models, and more.
Dating back to 2006, Viva’s team has been known for pioneering structural biology services. Viva’s experience, track record, and number of project teams focused in protein science are unmatched by any other company in China. By building on this strength, Viva is determined to increase the existing service model, build additional project teams with the same scientific rigor and quality, and expand into other challenging disciplines that play key roles in drug discovery research. Viva is keen on improving its technology and expertise while distinguishing itself from large chemistry-focused CROs.
Viva is designed with a setup similar to a pharmaceutical company to better serve the pharmaceutical industry. To ensure that there are no conflicts of interest, Viva is not proactively pursuing drug discovery on its own but rather works hard to protect their client’s IP with all the necessary procedures and mandates in place.
Currently, in vivo models set up at Viva are focused on disease areas such as oncology, diabetes, and pain. We are actively seeking stand-alone projects and welcome partnerships with any company which is interested in preclinical drug discover. Our current business models are illustrated below:
- Website
- www.vivabiotech.com
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